8-(4-(trifluoromethyl)benzyloxy)quinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-(4-(trifluoromethyl)benzyloxy)quinoline
• 英文别名: 8-[[4-(Trifluoromethyl)phenyl]methoxy]quinoline
• 化学式: C₁₇H₁₂F₃NO
• 分子量: 303.284
• InChiKey: YYJXJHJOUQETBU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  8-羟基喹啉 、 alkaline earth salt of/the/ methylsulfuric acid 在 四丁基溴化铵 、 potassium hydroxide 作用下， 以 二氯甲烷 、 水 为溶剂， 以90%的产率得到8-(4-(trifluoromethyl)benzyloxy)quinoline
  参考文献：
  名称：

  Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities

  摘要：

  A series of 8-benzyloxy-substituted quinoline ethers (2a-n) compounds were synthesized. All synthesized compounds were screened in vitro for their preliminary antimicrobial activities against two Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), two Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), and a fungal species (Aspergillus niger). Among all synthesized compounds, compound 2e showed a significant growth inhibitory activity with MIC value 3.125 mu g/mL which was comparable to 8-hydroxyquinoline (2.5 mu g/mL) and terbinafine (1.25 mu g/mL) against A. niger.

  DOI：

  10.1007/s00044-014-1217-4

文献信息

• OXIMINO DERIVATIVES FOR THE TREATMENT OF DYSLIPIDEMIA
  申请人：CADILA HEALTHCARE LIMITED

  公开号：US20160083380A1

  公开（公告）日：2016-03-24

  Compounds of the general formula (I), including their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use of these compounds and the intermediates involved in their preparation.

  通式（I）的化合物，包括其互变异构体、立体异构体、药用盐、含有它们的药物组合物、其制备方法、这些化合物的用途以及其制备过程中涉及的中间体。
• [EN] NOVEL 6-PHENYLPHENANTHRIDINES<br/>[FR] NOUVELLES 6-PHENYLPHENANTHRIDINES
  申请人：ALTANA PHARMA AG

  公开号：WO2005012253A1

  公开（公告）日：2005-02-10

  Compounds of a certain formula (I), in which R1, R2, R3, R31, R4, R5, R51, R6, R7 and R8 have the meanings indicated in the description, are novel effective PDE4 inhibitors.

  具有以下含义的化合物(I)，其中R1、R2、R3、R31、R4、R5、R51、R6、R7和R8的含义如说明书所示，是新型有效的PDE4抑制剂。
• OXIME COMPOUNDS, THEIR USE, AND INTERMEDIATES FOR THEIR PRODUCTION
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP0975586A2

  公开（公告）日：2000-02-02
• NOVEL 6-PHENYLPHENANTHRIDINES
  申请人：ALTANA Pharma AG

  公开号：EP1658271A1

  公开（公告）日：2006-05-24
• [EN] OXIME COMPOUNDS, THEIR USE, AND INTERMEDIATES FOR THEIR PRODUCTION<br/>[FR] COMPOSES D'OXIME, LEUR UTILISATION ET INTERMEDIAIRES POUR LEUR PRODUCTION
  申请人：——

  公开号：WO1998045254A2

  公开（公告）日：1998-10-15

  [EN] Oxime compounds of formula (1) wherein R<1>, R<2>, and R<3> are independently halogen, C1-C3 alkyl, C1-C3 haloalkyl, C1-C3 alkoxy, C1-C3 haloalkoxy, nitro, or cyano; R<4> is 3,3-dihalogeno-2-propenyl; a is an integer of 0 to 2; Y is oxygen, sulfur, or NH; Z is oxygen, sulfur, or NR<5>; wherein R<5> is hydrogen, acetyl, or C1-C3 alkyl; and X is of formula (2) insecticidal/acaricidal agents containing them as active ingredients; and intermediates for their production.
  [FR] La présente invention concerne des composés d'oxime représentés par la formule (1) dans laquelle: R1, R2, et R3 sont indépendamment un halogène, un alkyle en C1-C3, un haloalkyle en C1-C3, un alcoxy en C1-C3, un haloalcoxy en C1-C3, un nitro, ou un cyano; R4 représente 3,3-dihalogéno-2-propényle; a représente un nombre entier compris entre 0 et 2; Y représente un oxygène, un soufre, ou un NH; Z représente un oxygène, un soufre, ou un groupe NR5 dans lequel R5 représente un hydrogène,un acétyle, ou un alkyle en C1-C3; et X est représenté par la formule (2). La présente invention concerne également des agents insecticides/ acaricides contenant lesdits composés en tant qu'ingrédients actifs et, des intermédiaires pour la production de ceux-ci.