2-(furan-2-yl)-5-methyl-1,3,4-thiadiazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(furan-2-yl)-5-methyl-1,3,4-thiadiazole
• 化学式: C₇H₆N₂OS
• 分子量: 166.203
• InChiKey: VPUBEYXULZRSAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  67.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-furanthiocarboxyhydrazide 、 N,N-二甲基乙酰胺 在 potassium hydrogensulfate 作用下， 反应 5.0h， 以78%的产率得到2-(furan-2-yl)-5-methyl-1,3,4-thiadiazole
  参考文献：
  名称：

  A KHSO4 promoted tandem synthesis of 1,3,4-thiadiazoles from thiohydrazides and DMF derivatives

  摘要：

  An efficient, simple and environmentally benign method for the construction of 1,3,4-thiadiazole skeletons via the tandem coupling and cyclization of thiohydrazides with DMF derivatives in the presence of KHSO4 has been reported. This method reveals good reactivity and functional group tolerance, and a broad series of 1,3,4-thiadiazoles were obtained in moderate to good yields. (C) 2020 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2020.152195

文献信息

• Quinuclidine Compounds as Alpha-7 Nicotinic Acetylcholine Receptor Ligands
  申请人：Bristol-Myers Squibb Company

  公开号：US20130131064A1

  公开（公告）日：2013-05-23

  The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.

  本披露提供了I式化合物及其盐，以及使用这些化合物的组合物和方法。这些化合物是尼古丁α7受体的配体，可能有助于治疗中枢神经系统的各种疾病，尤其是情感和神经退行性疾病。
• QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20150094309A1

  公开（公告）日：2015-04-02

  The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.

  本公开提供I式化合物及其盐，以及使用该化合物的组合物和方法。该化合物是尼古丁α7受体的配体，可用于治疗中枢神经系统的各种障碍，特别是情感和神经退行性障碍。
• New utilities of amide compounds
  申请人：Yamamori Teruo

  公开号：US20080221112A1

  公开（公告）日：2008-09-11

  Compounds having an activity to enhance the expression of apoAI are provided, which are used as medicaments. Compounds of formula (I): in which ring A and Ar 1 are independently a monocyclic or bicyclic aromatic carbocyclic group or aromatic heterocyclic group, each of which may be optionally substituted, or the like; R is a hydrogen or the like; Z is oxygen or the like; Y 1 and Y 2 are a hydrogen, a lower alkyl, or the like; n is an integer of 0 to 2; the broken line is the presence or absence of a bond; and the wavy line represents a cis- or trans-geometrical isomerism with respect to the double bond; are disclosed.
• US7429593B2
  申请人：——

  公开号：US7429593B2

  公开（公告）日：2008-09-30
• US8106051B2
  申请人：——

  公开号：US8106051B2

  公开（公告）日：2012-01-31