2,4-dibenzoyl-1,5-dimorpholinopentane-1,5-dione

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,4-dibenzoyl-1,5-dimorpholinopentane-1,5-dione
• 英文别名: 2,4-Dibenzoyl-1,5-dimorpholin-4-ylpentane-1,5-dione；2,4-dibenzoyl-1,5-dimorpholin-4-ylpentane-1,5-dione
• 化学式: C₂₇H₃₀N₂O₆
• 分子量: 478.545
• InChiKey: OBSABNXOTNLHIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  93.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  N,N-二甲基乙酰胺 、 1-morpholino-3-phenylpropane-1,3-dione 在 叔丁基过氧化氢 、 碘 作用下， 反应 24.0h， 以30%的产率得到2,4-dibenzoyl-1,5-dimorpholinopentane-1,5-dione
  参考文献：
  名称：

  Metal-Free Csp3–N Bond Cleavage of Amides Using tert-Butyl Hydroperoxide as Oxidant

  摘要：

  A mild and efficient protocol for the metal-free C-N bond-cleavage of amides has been developed. The methodology employs iodine as a catalyst to cleave the C(Me)-N bond of dimethylformamide or dimethylacetamide, providing novel access to methylene-bridged bis-1,3-dicarbonyl compounds instead of enol carbamates in the presence of tert-butyl hydroperoxide.

  DOI：

  10.1055/s-0034-1379879

文献信息

• Metal-Free Csp3–N Bond Cleavage of Amides Using tert-Butyl Hydroperoxide as Oxidant
  作者：Hu Cai、Shengmei Guo、Zheng Zhu、Lin Lu、Wenbiao Zhang、Jiuhan Gong

  DOI：10.1055/s-0034-1379879

  日期：——

  A mild and efficient protocol for the metal-free C-N bond-cleavage of amides has been developed. The methodology employs iodine as a catalyst to cleave the C(Me)-N bond of dimethylformamide or dimethylacetamide, providing novel access to methylene-bridged bis-1,3-dicarbonyl compounds instead of enol carbamates in the presence of tert-butyl hydroperoxide.