N-(3,4-dimethoxycinnamoyl)anthranilic acid sodium salt

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: N-(3,4-dimethoxycinnamoyl)anthranilic acid sodium salt
• 英文别名: tranilast sodium salt；Sodium Tranilast;MK 341 Sodium;SB 252218 Sodium；sodium;2-[3-(3,4-dimethoxyphenyl)prop-2-enoylamino]benzoate
• 化学式: C₁₈H₁₆NO₅*Na
• 分子量: 349.319
• InChiKey: KZGHWWBBHZLTTA-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.28
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  87.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  曲尼司特 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 以84%的产率得到N-(3,4-dimethoxycinnamoyl)anthranilic acid sodium salt
  参考文献：
  名称：

  曲尼司特的盐

  摘要：

  曲尼司特的盐。本发明涉及N‑(3,4‑二甲氧基肉桂酰)邻氨基苯甲酸的盐，尤其是氨丁三醇盐，包含所述盐的药物制剂，及其在制备针对过敏性疾病的药物中的应用。

  公开号：

  CN111440086A

文献信息

• 曲尼司特的盐
  申请人：南京诺瑞特医药科技有限公司

  公开号：CN111440086A

  公开（公告）日：2020-07-24

  曲尼司特的盐。本发明涉及N‑(3,4‑二甲氧基肉桂酰)邻氨基苯甲酸的盐，尤其是氨丁三醇盐，包含所述盐的药物制剂，及其在制备针对过敏性疾病的药物中的应用。
• Approach of Cocrystallization to Improve the Solubility and Photostability of Tranilast
  作者：Na Geng、Jia-Mei Chen、Zi-Jian Li、Long Jiang、Tong-Bu Lu

  DOI：10.1021/cg400518w

  日期：2013.8.7

  The cocrystals and salts of an antiallergic drug, tranilast, were synthesized to improve its solubility and photostability. Two tranilast cocrystals with urea (1) and nicotinamide (2), as well as two salts with cytosine (3) and sodium ion (4), were obtained and characterized by infrared spectra, thermogravimetric analyses, differential scanning calorimetry, and powder and single crystal X-ray diffractions. The results of single crystal structure analyses of 1-3 indicate that tranilast combines amide groups in coformers via R-2(2) (8) synthon, resulting in a 1:1 stoichiometry. The complexes showed advantages in terms of solubility and photostability in comparison to pure tranilast. The maximum solubility values of 1-3 in phosphate buffer of pH 6.8 are approximately 1.6, 1.9, and 2.0 times as large as that of tranilast, and the residual of tranilast is 79.5, 92.9, 88.5, 86.2, and 87.4% for tranilast and 1-4, respectively, under the fluorescent lamp irradiation for 96 h.