3-((1H-indol-3-yl)(3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)methyl)-1H-indole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-((1H-indol-3-yl)(3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)methyl)-1H-indole
• 英文别名: 3-[1H-indol-3-yl-[3-(4-methoxyphenyl)-1-phenylpyrazol-4-yl]methyl]-1H-indole
• 化学式: C₃₃H₂₆N₄O
• 分子量: 494.596
• InChiKey: VSQFRAWADYBZGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  38
• 可旋转键数：
  6
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  吲哚 、 3-(4-甲氧基苯基)-1-苯基-1H-吡唑-4-甲醛 在 Amberlyst 15 作用下， 以 氯仿 为溶剂， 以96%的产率得到3-((1H-indol-3-yl)(3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)methyl)-1H-indole
  参考文献：
  名称：

  Amberlyst 15 catalyzed synthesis of indole–pyrazole based tri(hetero)arylmethanes

  摘要：

  DOI：

  10.1016/j.tetlet.2004.04.172

文献信息

• Synthesis of pyrazolylbisindoles over mesoporous Lewis acidic ZrTUD-1: Potential application in selective Cu2+ colorimetric detection
  作者：Karthikeyan Kandasamy、Sivaprasad Ganesabaskaran、Muthusamy Poomalai Pachamuthu、Rajamanickam Maheswari、Anand Ramanathan

  DOI：10.1016/j.saa.2015.05.009

  日期：2015.11

  A series of pyrazolylbisindole (PBI) derivatives were prepared by simple condensation of indole and pyrazole aldehyde utilizing amorphous mesoporous ZrTUD-1 having predominant Lewis acid sites. The applicability of pyrazolylbisindolyl derivate as a colorimetric chemosensor with high selectivity toward Cu2+ over other cations were tested. Among heavy and transition metal (HTM) ions in CH3CN solution, the probe only sensed Cu2+ detectable by naked eye. The sensor exhibited a new absorption band at 488 nm (a red shift of 206 nm from 282 nm) with a large colorimetric response and affinity to Cu2+ over other cations tested (Al3+, Pb2+, Cd2+, Mg2+, Mn2+, Zn2+, K+, Fe2+, Ca2+, Cu2+ and Hg2+). (c) 2015 Elsevier B.V. All rights reserved.