1-(2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)pyrrolidin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)pyrrolidin-2-one
• 英文别名: 1-[(2S,4S)-2-methyl-1,2,3,4-tetrahydroquinolin-4-yl]pyrrolidin-2-one
• 化学式: C₁₄H₁₈N₂O
• 分子量: 230.31
• InChiKey: LHFKTMHOXRRTJK-GWCFXTLKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.55
• 重原子数：
  17.0
• 可旋转键数：
  1.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  32.34
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  N-乙烯基吡咯烷酮 、 苯胺 以 水 为溶剂， 反应 24.0h， 以93%的产率得到1-(2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)pyrrolidin-2-one
  参考文献：
  名称：

  Catalyst-free diastereoselective synthesis of 2-methyl-4-amino-1,2,3,4-tetrahydro-quinoline derivatives in water

  摘要：

  A diastereoselective synthesis of 2-methyl-4-amino-1,2,3,4-tetrahydro-quinoline derivatives was achieved through the reaction of aromatic amines and tert-enamides in water under reflux conditions. The desired products could be obtained in moderate to excellent yields utilizing water as solvent without any catalyst or additive. (C) 2013 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2013.03.091

文献信息

• Catalyst-free diastereoselective synthesis of 2-methyl-4-amino-1,2,3,4-tetrahydro-quinoline derivatives in water
  作者：Lin Wu、Ran Jiang、Jin-Ming Yang、Shun-Yi Wang、Shun-Jun Ji

  DOI：10.1016/j.tetlet.2013.03.091

  日期：2013.5

  A diastereoselective synthesis of 2-methyl-4-amino-1,2,3,4-tetrahydro-quinoline derivatives was achieved through the reaction of aromatic amines and tert-enamides in water under reflux conditions. The desired products could be obtained in moderate to excellent yields utilizing water as solvent without any catalyst or additive. (C) 2013 Published by Elsevier Ltd.