二-(二乙基氨基)-叔丁氧基膦 | 118818-64-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 二-(二乙基氨基)-叔丁氧基膦
• 英文名称: tert-butyl tetraethylphosphorodiamidite
• 英文别名: tert-butyl(tetraethyldiamido)phosphite；Bis(diethylamino)-tert-butoxyphosphine；N-[diethylamino-[(2-methylpropan-2-yl)oxy]phosphanyl]-N-ethylethanamine
• CAS: 118818-64-7
• 化学式: C₁₂H₂₉N₂OP
• 分子量: 248.349
• InChiKey: OTBZBDJLDICQBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  二-(二乙基氨基)-叔丁氧基膦 在 氯乙酸乙酯 作用下， 反应 1.5h， 以78%的产率得到双(二乙基胺基)磷酰氯
  参考文献：
  名称：

  摘要：

  Reactions of ethyl and tert-butyl phosphorodiamidites with chloroacetone, bromoacetone, and alpha-chloroethyl acetate were studied. The reaction pathway is determined by the structure of the intermediate quasiphosphonium compound responsible for the formation of the Arbuzov product as well as for the occurrence of the amonalous reaction yielding vinyl phosphate.

  DOI：

  10.1023/a:1023397330794
• 作为产物：
  描述：

  二乙胺 、 acetyl tert-butyl diethylphosphoramidite 生成 二-(二乙基氨基)-叔丁氧基膦
  参考文献：
  名称：

  摘要：

  Reactions of tert-butyl tetraethylphosphorodiamidite with acetic and trifluoroacetic acids involve substitution of the amido group. Ibis process was described by a scheme beginning with protonation of phosphorus and proved by modeling separate reaction stages. A probable scheme of the proposed reactions is described.

  DOI：

  10.1023/a:1024723517711
• 作为试剂：
  描述：

  溴代丙二酸二乙酯 在 二-(二乙基氨基)-叔丁氧基膦 作用下， 生成 1,1,2,2-乙烷四甲酸四乙酯
  参考文献：
  名称：

  摘要：

  DOI：

  10.1023/a:1023479716198

文献信息

• Sal'keeva, L. K.; Usmanova, L. N.; Gazizov, T. Kh., Journal of general chemistry of the USSR, 1992, vol. 62, # 2.1, p. 269 - 273
  作者：Sal'keeva, L. K.、Usmanova, L. N.、Gazizov, T. Kh.

  DOI：——

  日期：——
• Gazizov, T. Kh.; Sal'keeva, L. K.; Gafurov, E. K., Journal of general chemistry of the USSR, 1988, vol. 58, # 5, p. 1028 - 1029
  作者：Gazizov, T. Kh.、Sal'keeva, L. K.、Gafurov, E. K.、Kazantsev, A. V.

  DOI：——

  日期：——
• ——
  作者：L. K. Sal'keeva、M. T. Nurmaganbetova、O. Sh. Kurmanaliev

  DOI：10.1023/a:1025624116438

  日期：——

  The reactions of 2-tert-butoxy-3-phenyl-1,3,2-oxazaphospholane and di-tert-butyl diethylphosphoramidite with carbon tetrachloride and chloroform were studied. These reactions proceed via formation of an intermediate quasiphosphonium compound. In the process, carbon tetrachloride acts as a source of positively charged halogen, and chloroform, as a C-H acid.
• Mechanism of Reactions of P(III) Amidoesters with Carboxylic Acid Chlorides
  作者：L. K. Sal'keeva、M. T. Nurmagambetova、O. Sh. Kurmanaliev

  DOI：10.1023/b:rugc.0000016008.08714.a5

  日期：2003.9
• ——
  作者：L. K. Sal'keeva、M. T. Nurmaganbetova、O. Sh. Kurmanaliev

  DOI：10.1023/a:1013930431749

  日期：——

  Reactions of tert-butyl tetraethylphosphorodiamidite with benzylideneacetylacetone, benzylideneacetoacetic ester, and benzylidenemalonic ester are studied. It is shown that the reaction pathway significantly depends on the solvent and temperature. The reaction with benzylidenacetylacetone in ether gives rise to a stable diketophosphonate, while the same reaction in boiling benzene involves elimination of diethylamine and yields a phospholene. The reaction with benzylideneacetoacetic ester proceeds analogously, while with benzylidenemalonic ester the corresponding phospholene is formed exclusively.