kaempferol-3-O-α-L-rhamnosyl-(1'''→6'')-O-β-D-galactopyranosyl-7-O-β-D-apiofuranoside

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: kaempferol-3-O-α-L-rhamnosyl-(1'''→6'')-O-β-D-galactopyranosyl-7-O-β-D-apiofuranoside
• 英文别名: 7-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)-3-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-[[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one
• 化学式: C₃₂H₃₈O₁₉
• 分子量: 726.642
• InChiKey: VIJQPIXPIYJSGT-CRJNTGDPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  51
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  304
• 氢给体数：
  11
• 氢受体数：
  19

反应信息

• 作为反应物：
  描述：

  kaempferol-3-O-α-L-rhamnosyl-(1'''→6'')-O-β-D-galactopyranosyl-7-O-β-D-apiofuranoside 在 盐酸 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 2.0h， 生成 D-apiose 、 L-鼠李糖 、 口服葡萄糖
  参考文献：
  名称：

  A new kaempferol trioside from Silphium perfoliatum

  摘要：

  A new apiose-containing kaempferol trioside, kaempferol-3-O-alpha-l-rhamnosyl-(1"'-> 6 '')-O-beta-d-galactopyranosyl-7-O-beta-d-apiofuranoside, along with 16 known compounds, were isolated from 50% acetone extract of Silphium perfoliatum L. Their structures were elucidated by acid hydrolysis and spectroscopic techniques including UV, IR, MS, H-1, C-13, and 2D-NMR. In addition, the pharmacological activity of compound 1 was tested with HepG2 and Balb/c mice (splenic lymphocytes and thymic lymphocytes) in vitro, and it exhibited inhibitory effect on the proliferation of HepG2 cells and showed the immunosuppressive activity.

  DOI：

  10.1080/10286020.2013.823951