Methyl O-(2,6-dimethoxypyrimidin-4-yl)salicylate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Methyl O-(2,6-dimethoxypyrimidin-4-yl)salicylate
• 英文别名: Methyl 2-(2,6-dimethoxypyrimidin-4-yl)oxybenzoate
• 化学式: C₁₄H₁₄N₂O₅
• 分子量: 290.276
• InChiKey: RCPXCFFRCSVHBU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  79.8
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  6-氯-2,4-甲氧基嘧啶 、 水杨酸甲酯 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 以38.5%的产率得到Methyl O-(2,6-dimethoxypyrimidin-4-yl)salicylate
  参考文献：
  名称：

  Dimethoxypyrimidines as Novel Herbicides. Part 2. Synthesis and Herbicidal Activity ofO-Pyrimidinylsalicylates and Analogues

  摘要：

  A new series of the O-pyrimidinylsalicylates was synthesized and their herbicidal activity was examined. Some of these compounds showed very strong herbicidal activity under pre- and post-emergent treatment conditions against various kinds of grass and broadleaf weeds. Among these compounds, O-(4, 6-dimethoxypyrimidin-2-yl) salicylic acid and its methyl ester were found to exhibit the highest activity. The herbicidal symptoms observed after the treatments included early cessation of plant growth followed by chlorosis, necrosis and plant death. The symptoms were similar to those caused by sulfonylureas and imidazolinones, which inhibit branched-chain amino acid biosynthesis.

  DOI：

  10.1002/(sici)1096-9063(199606)47:2<115::aid-ps397>3.0.co;2-r

文献信息

• Dimethoxypyrimidines as Novel Herbicides. Part 2. Synthesis and Herbicidal Activity of<i>O</i>-Pyrimidinylsalicylates and Analogues
  作者：Yukio Nezu、Masahiro Miyazaki、Kazuhiko Sugiyama、Nobuhide Wada、Ikuo Kajiwara、Takeshige Miyazawa

  DOI：10.1002/(sici)1096-9063(199606)47:2<115::aid-ps397>3.0.co;2-r

  日期：1996.6

  A new series of the O-pyrimidinylsalicylates was synthesized and their herbicidal activity was examined. Some of these compounds showed very strong herbicidal activity under pre- and post-emergent treatment conditions against various kinds of grass and broadleaf weeds. Among these compounds, O-(4, 6-dimethoxypyrimidin-2-yl) salicylic acid and its methyl ester were found to exhibit the highest activity. The herbicidal symptoms observed after the treatments included early cessation of plant growth followed by chlorosis, necrosis and plant death. The symptoms were similar to those caused by sulfonylureas and imidazolinones, which inhibit branched-chain amino acid biosynthesis.