dodecafluoroheptanol

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代醇
• 英文名称: dodecafluoroheptanol
• 英文别名: dodecafluoroheptyl alcohol；1,1,2,2,3,3,4,4,5,5,6,6-Dodecafluoroheptan-1-OL
• 化学式: C₇H₄F₁₂O
• 分子量: 332.089
• InChiKey: XXFOZACSOFLKAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  13

反应信息

• 作为反应物：
  描述：

  dodecafluoroheptanol 以 全氟正戊烷 为溶剂， 生成 八氟代-1-戊醇
  参考文献：
  名称：

  Phase shift colloids as ultrasound contrast agents

  摘要：

  用于增强诊断超声成像对比度的药剂包括液滴-液滴型胶体分散液，即乳液或微乳液。其中分散的液滴相是一种沸点低于待成像动物体温的液体，因此在注入动物后会从分散液体相转变为高回声分散气泡或库格尔沙发。分散相的液态状态使得人们能够制造极其稳定、药学上可接受的乳液，其粒径通常小于1000纳米。在体温下的气态状态产生高回声的微小气泡，其直径通常小于10000纳米，能够有效作为超声成像对比剂。文中描述了静脉、动脉内、口服、腹腔内和子宫内剂型、给药方法和成像技术。

  公开号：

  US05558853A1
• 作为产物：
  描述：

  全氟正戊烷 生成 dodecafluoroheptanol
  参考文献：
  名称：

  Method for preparing storage stable colloids

  摘要：

  用于增强诊断超声波程序中对比度的药剂包括液体-液体类型的胶体分散体，即乳液或微乳液，其中分散的液相是高蒸汽压化学物质，经过从分散液相到高度回声分散气泡或库格尔沫的相变后，向生物体内施用。分散相的液态使得可以制造颗粒尺寸通常低于1000纳米的极其稳定、药学上可接受的乳液。在体温下的气态产生高度回声的微泡，直径通常低于10,000纳米，这些微泡可作为超声造影剂。描述了静脉、动脉内、口服、腹腔内和子宫内剂型、给药方法和成像技术。

  公开号：

  US05595723A1

文献信息

• Microbubble formation using ultrasound
  申请人：——

  公开号：US20030032879A1

  公开（公告）日：2003-02-13

  Disclosed herein are agents for enhancing the contrast in a diagnostic ultrasound procedure. These agents comprise colloidal dispersions of the liquid-in-liquid type, i.e., emulsions or microemulsions, in which the dispersed liquid phase has a boiling point at or below the body temperature of the organism to be studied and thus undergoes a phase change from a dispersed liquid to a highly echogenic dispersed gaseous foam or kugelschaum following administration to an organism. The liquid state of the dispersed phase allows one to manufacture extremely stable, pharmaceutically acceptable emulsions with particle sizes typically below 1000 nm. The gaseous state at body temperature yields highly echogenic microbubbles, typically below 10,000 nm in diameter, which are effective as ultrasound contrast agents. Intravenous, intraarterial, oral, intraperitoneal, and intrauterine dosage forms, methods of administration, and imaging techniques are described.

  本文公开了一种增强诊断超声成像对比度的药剂。这些药剂包括液体-液体型胶体分散液，即乳液或微乳液，其中分散液相在被检测生物体的体温以下沸点，因此在给生物体注射后从分散液体相转变为高声学对比度的分散气态泡沫或库格尔沙。分散相的液态使得可以制造粒径通常低于1000纳米的极其稳定的药用乳剂。体温下的气态产生高声学对比度的微泡，直径通常低于10,000纳米，有效作为超声对比剂。描述了静脉、动脉内、口服、腹腔内和子宫内剂量形式、给药方法和成像技术。
• Colloidal dispersions of perfluoropentane
  申请人：Sonus Pharmaceuticals, Inc.

  公开号：US06245319B1

  公开（公告）日：2001-06-12

  Agents for enhancing the contrast in a diagnostic ultrasound procedure comprise colloidal dispersions of the liquid-in-liquid type, i.e., emulsions or microemulsions, in which the dispersed liquid phase is a liquid having a boiling point below the temperature of the animal to be imaged and which therefore undergoes a phase change from a dispersed liquid to a highly echogenic dispersed gaseous foam or kugelschaum following administration to the animal. The liquid state of the dispersed phase allows one to manufacture extremely stable, pharmaceutically acceptable emulsions with particle sizes typically below 1000 nm. The gaseous state at body temperature yields highly echogenic microbubbles, typically below 10,000 nm in diameter, which are effective as ultrasound contrast agents. Intravenous, intraarterial, oral, intraperitoneal, and intrauterine dosage forms, methods of administration, and imaging techniques are described.

  用于增强诊断超声程序对比度的制剂包括液-液型的胶体分散液，即乳液或微乳液。其中分散液相是一种沸点低于待成像动物温度的液体，因此在给动物注射后会从分散液体相变为高回声分散气泡或球形泡沫。分散相的液态允许制造极其稳定、药学上可接受的乳液，其粒径通常小于1000nm。在体温下的气态产生高回声微泡，其直径通常小于10,000nm，是有效的超声对比剂。描述了静脉、动脉内、口服、腹腔内和子宫内剂量形式、给药方法和成像技术。
• Composition comprising a fluorine containing surfactant and
  申请人：Sonus Pharmaceuticals, Inc.

  公开号：US05876696A1

  公开（公告）日：1999-03-02

  Agents for enhancing the contrast in a diagnostic ultrasound procedure comprise colloidal dispersions of the liquid-in-liquid type, i.e., emulsions or microemulsions, in which the dispersed liquid phase is a high vapor pressure chemical which undergoes a phase change from a dispersed liquid to a highly echogenic dispersed gaseous foam or kugelschaum following administration to an organism. The liquid state of the dispersed phase allows one to manufacture extremely stable, pharmaceutically acceptable emulsions with particle sizes typically below 1000 nm. The gaseous state at body temperature yields highly echogenic microbubbles, typically below 10,000 nm in diameter, which are effective as ultrasound contrast agents. Intravenous, intraarterial, oral, intraperitoneal, and intrauterine dosage forms, methods of administration, and imaging techniques are described.

  增强诊断超声成像对比度的药剂，包括液-液型胶体分散体，即乳液或微乳液，其中分散的液相是高蒸汽压化学物质，在给生物体内注射后会从分散液体相变为高回声分散气态泡沫或库格尔沙。分散相的液态状态使得可以制造粒径通常小于1000纳米的极其稳定、药学上可接受的乳液。体温下的气态状态产生高回声的微泡，直径通常小于10,000纳米，有效作为超声对比剂。描述了静脉、动脉内、口服、腹腔内和子宫内剂型、给药方法和成像技术。
• CURABLE FLUOROPOLYMER COMPOSITIONS
  申请人：Oriani Steven R.

  公开号：US20100069554A1

  公开（公告）日：2010-03-18

  Polyhydroxy curable fluoropolymer compositions comprise polyhydroxy curable fluoropolymer, a β-fluoroalcohol having the formula R—(CF 2 )n-CH 2 —OH, wherein R is H, F or CH 3 O and n is an integer from 2 to 7, a polyhydroxy curative, acid acceptor and accelerator.

  聚羟基可固化氟聚合物组合物包括聚羟基可固化氟聚合物、具有以下公式的β-氟醇R—（CF2）n-CH2—OH，其中R是H，F或CH3O，n是从2到7的整数，聚羟基固化剂、酸接受剂和加速剂。
• POLYCARBONATE NANOCOMPOSITES
  申请人：Maiti Parnasree

  公开号：US20120149839A1

  公开（公告）日：2012-06-14

  Polycarbonate nanocomposites comprising a polycarbonate matrix having non-oxidized metal nanoparticles dispersed therein are disclosed. The polycarbonate nanocomposite is produced by a process comprising forming a reaction mixture comprising a dihydroxy compound, an activated carbonate, a metal precursor, and a solvent; and in-situ polymerizing the reaction mixture to form a nanocomposite comprising a polycarbonate matrix and metal nanoparticles dispersed therein. The metal precursor comprises a metal selected from a specified group. The nanocomposites have improved mechanical, optical, electrical and/or magnetic properties. Also disclosed are articles formed from such polycarbonate nanocomposites.

  本发明涉及一种聚碳酸酯纳米复合材料，其包括散布有未氧化金属纳米颗粒的聚碳酸酯基质。该聚碳酸酯纳米复合材料是通过以下工艺制备的：形成反应混合物，其中包括二羟基化合物、活性碳酸酯、金属前体和溶剂；并原位聚合反应混合物，形成一个包括聚碳酸酯基质和散布有金属纳米颗粒的纳米复合材料。金属前体包括从特定组中选择的金属。该纳米复合材料具有改善的机械、光学、电学和/或磁学性能。还公开了由此类聚碳酸酯纳米复合材料形成的物品。