cis-N-(2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)formamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: cis-N-(2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)formamide
• 英文别名: N-(2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)formamide
• 化学式: C₁₁H₁₄N₂O
• 分子量: 190.245
• InChiKey: XROFDIKKABZNLR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.68
• 重原子数：
  14.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  41.13
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  N-乙烯基甲酰胺 、 苯胺 在 phosphomolybdic acid 作用下， 反应 3.0h， 以63%的产率得到cis-N-(2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)formamide
  参考文献：
  名称：

  Grinding and Milling: Two Efficient Methodologies in the Solvent-Free Phosphomolybdic Acid-Catalyzed and Mechanochemical Synthesis ofcis-4-Amido-N-yl-2-methyl-tetrahydroquinolines

  摘要：

  The ball-milling process of ABB' Povarov reaction through mechano-chemical activation with phosphomolybdic acid (PMA) as heteropolyacid (HPA) catalyst, was first time explored. The developed high speed vibratory ball milling (HSVBM) green method offers simple and efficient diastereoselective synthesis of cis-2,4-disubstituted tetrahydroquinolines in good to excellent yields (56-76%).

  DOI：

  10.5935/0103-5053.20160117

文献信息

• Grinding and Milling: Two Efficient Methodologies in the Solvent-Free Phosphomolybdic Acid-Catalyzed and Mechanochemical Synthesis of<i>cis</i>-4-Amido-<i>N</i>-yl-2-methyl-tetrahydroquinolines
  作者：Vladimir V. Kouznetsov、Diego R. Merchán-Arenas、Carlos A. Martínez-Bonilla、Mario A. Macías、Pascal Roussel、Gilles H. Gauthier

  DOI：10.5935/0103-5053.20160117

  日期：——

  The ball-milling process of ABB' Povarov reaction through mechano-chemical activation with phosphomolybdic acid (PMA) as heteropolyacid (HPA) catalyst, was first time explored. The developed high speed vibratory ball milling (HSVBM) green method offers simple and efficient diastereoselective synthesis of cis-2,4-disubstituted tetrahydroquinolines in good to excellent yields (56-76%).