tetramethyl(N,6-dimethyl-1,2,3,4-tetrahydroquinoline-2,4-diyl)bis(phosphonate)

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: tetramethyl(N,6-dimethyl-1,2,3,4-tetrahydroquinoline-2,4-diyl)bis(phosphonate)
• 英文别名: 2,4-bis(dimethoxyphosphoryl)-1,6-dimethyl-3,4-dihydro-2H-quinoline
• 化学式: C₁₅H₂₅NO₆P₂
• 分子量: 377.314
• InChiKey: IDFKBJXJACGMLL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  74.3
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  6-甲基喹啉 、 亚磷酸二甲酯 以 甲苯 为溶剂， 反应 20.0h， 以88%的产率得到tetramethyl(N,6-dimethyl-1,2,3,4-tetrahydroquinoline-2,4-diyl)bis(phosphonate)
  参考文献：
  名称：

  Direct diphosphonylation of quinolines with H-phosphonates under metal-free conditions

  摘要：

  The'one pot' synthesis of 2,4-diphosphono-1,2,3,4-tetrahydroquinolines starting from quinolines and H-phosphonates has been developed. This transformation involves continuous twice hydro-phosphonylation regioselectively and breaks up the aromatic stabilization, which features a simple system, high efficiency, environmental friendliness, under the additives and metal-free conditions. Various of 2,4-diphosphono-1,2,3,4-tetrahydroquinolines were provided in up to 95% yield for 20 examples. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2015.07.001

文献信息

• Direct diphosphonylation of quinolines with H-phosphonates under metal-free conditions
  作者：Qianqian Zhang、Donghui Wei、Xiuling Cui、Duo Zhang、Hui Wang、Yangjie Wu

  DOI：10.1016/j.tet.2015.07.001

  日期：2015.9

  The'one pot' synthesis of 2,4-diphosphono-1,2,3,4-tetrahydroquinolines starting from quinolines and H-phosphonates has been developed. This transformation involves continuous twice hydro-phosphonylation regioselectively and breaks up the aromatic stabilization, which features a simple system, high efficiency, environmental friendliness, under the additives and metal-free conditions. Various of 2,4-diphosphono-1,2,3,4-tetrahydroquinolines were provided in up to 95% yield for 20 examples. (C) 2015 Elsevier Ltd. All rights reserved.