TPFBME

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: TPFBME
• 英文别名: 1,3-Bis[[1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-yl]oxy]-2-[[1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-yl]oxymethyl]-2-methylpropane
• 化学式: C₁₇H₉F₂₇O₃
• 分子量: 774.214
• InChiKey: ZRRKREAZEVIWIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.1
• 重原子数：
  47
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  30

反应信息

• 作为产物：
  描述：

  1,1,1-三(羟甲基)乙烷 、 高氟叔丁醇 在 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 为溶剂， 反应 28.0h， 以40%的产率得到TPFBME
  参考文献：
  名称：

  基于全氟化碳的19 F MRI纳米探针，用于体内多色成像。

  摘要：

  体内多色成像对于监测生物学中的多个生物分子或细胞过程非常重要。19 F磁共振成像（MRI）是一种新兴的体内成像技术，因为它可以无创地观察19 F核而没有内源性背景信号。因此，迫切需要能够进行多色成像的19 F MRI探针。在本文中，我们报告了五种类型的全氟化碳包裹的二氧化硅纳米粒子，它们显示出具有不同化学位移的19 F NMR峰。选择了三个纳米探针，它们以足够的灵敏度显示出光谱上不同的19 F NMR峰，用于体内多色19 F MRI。纳米探针在活着的小鼠中表现出三种颜色的19 F MRI信号。我们的体内多色系统可用于评估表面官能团对小鼠肝脏吸收的影响。

  DOI：

  10.1002/anie.201810363

文献信息

• Paramagnetic nanoemulsions with unified signals for sensitive ¹⁹F MRI cell tracking
  作者：Qiaoli Peng、Yu Li、Shaowei Bo、Yaping Yuan、Zhigang Yang、Shizhen Chen、Xin Zhou、Zhong-Xing Jiang

  DOI：10.1039/c8cc02938e

  日期：——

  A paramagnetic nanoemulsion with a unified ¹⁹F NMR signal facilitates sensitive ¹⁹F MRI cell tracking.

  一种具有统一¹⁹F NMR信号的顺磁纳米乳剂有助于敏感的¹⁹F MRI细胞追踪。
• Perfluorocarbon‐Based ¹⁹ F MRI Nanoprobes for In Vivo Multicolor Imaging
  作者：Kazuki Akazawa、Fuminori Sugihara、Tatsuya Nakamura、Hisashi Matsushita、Hiroaki Mukai、Rena Akimoto、Masafumi Minoshima、Shin Mizukami、Kazuya Kikuchi

  DOI：10.1002/anie.201810363

  日期：2018.12.17

  In vivo multicolor imaging is important for monitoring multiple biomolecular or cellular processes in biology. 19 F magnetic resonance imaging (MRI) is an emerging in vivo imaging technique because it can non-invasively visualize 19 F nuclei without endogenous background signals. Therefore, 19 F MRI probes capable of multicolor imaging are in high demand. Herein, we report five types of perfluorocarbon-encapsulated

  体内多色成像对于监测生物学中的多个生物分子或细胞过程非常重要。19 F磁共振成像（MRI）是一种新兴的体内成像技术，因为它可以无创地观察19 F核而没有内源性背景信号。因此，迫切需要能够进行多色成像的19 F MRI探针。在本文中，我们报告了五种类型的全氟化碳包裹的二氧化硅纳米粒子，它们显示出具有不同化学位移的19 F NMR峰。选择了三个纳米探针，它们以足够的灵敏度显示出光谱上不同的19 F NMR峰，用于体内多色19 F MRI。纳米探针在活着的小鼠中表现出三种颜色的19 F MRI信号。我们的体内多色系统可用于评估表面官能团对小鼠肝脏吸收的影响。
• Peptide-based multimeric targeted contrast agents
  申请人：Zhang Zhaoda

  公开号：US20060039861A1

  公开（公告）日：2006-02-23

  Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.

  本文描述了肽和肽靶向多聚对比剂，以及制备和使用对比剂的方法。
• The design and synthesis of highly branched and spherically symmetric fluorinated oils and amphiles
  作者：Zhong-Xing Jiang、Y. Bruce Yu

  DOI：10.1016/j.tet.2007.03.004

  日期：2007.5

  A new surfactant design principle, based on concepts borrowed from protein science, is proposed. Using this principle, a class of highly branched and spherically symmetric fluorinated oils and amphiles has been designed and synthesized, for potential applications in the construction of fluorocarbon nanoparticles. The Mitsunobu reaction was employed as the key step for introducing three perfluoro-tert-butoxyl groups into pentaerythritol derivatives with excellent yields and extremely simple isolation procedures. Due to the symmetric arrangement of the fluorine atoms, each fluorinated oil or amphile molecule gives one sharp singlet F-19 NMR signal. (C) 2007 Elsevier Ltd. All rights reserved.
• HIGHLY FLUORINATED OILS AND SURFACTANTS AND METHODS OF MAKING AND USING SAME
  申请人：Yu Yihua

  公开号：US20090264397A1

  公开（公告）日：2009-10-22

  Disclosed are compounds comprising the structure: In one aspect, the compounds exhibit maximum symmetric branching. Also disclosed are bilayers, micelles, coatings, and nanoparticles comprising the disclosed compounds. Also disclosed are processes for the preparation of the disclosed compounds and methods of using the disclosed compounds. Also disclosed are highly fluorinated dendrons and methods for making same. Also disclosed are methods for Fluorous Mixture Synthesis and tagging. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.