methyl 6-amino-5-cyano-4-(4-cyanophenyl)-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-3-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: methyl 6-amino-5-cyano-4-(4-cyanophenyl)-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-3-carboxylate
• 英文别名: methyl 6-amino-5-cyano-4-(4-cyanophenyl)-1-phenyl-4H-pyrano[2,3-c]pyrazole-3-carboxylate
• 化学式: C₂₂H₁₅N₅O₃
• 分子量: 397.393
• InChiKey: GAHBUVLZGPDDPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  127
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  苯肼 、 4-氰基苯甲醛 、 丁炔二酸二甲酯 、 丙二腈 在 tin(IV) oxide 作用下， 以 水 为溶剂， 反应 1.5h， 以94%的产率得到methyl 6-amino-5-cyano-4-(4-cyanophenyl)-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-3-carboxylate
  参考文献：
  名称：

  Uncapped SnO2 quantum dot catalyzed cascade assembling of four components: a rapid and green approach to the pyrano[2,3-c]pyrazole and spiro-2-oxindole derivatives

  摘要：

  A new uncapped SnO2 quantum dots (QDs) catalyzed strategy for the synthesis of substituted pyrano [2,3-c]pyrazole and spiro-2-oxindole derivatives has been developed via a multicomponent one pot approach in aqueous medium. The reactions can be performed at low catalyst loadings with excellent functional group tolerance. This communication also reports a comparative study of the efficiency related to the catalytic activity of uncapped SnO2 QDs, oleic acid capped SnO2 QDs, and SnO2 nanoflower. Uncapped SnO2 QDs, capped SnO2 QDs, and SnO2 nanoflower were prepared by simple solvothermal method and characterized by XRD, FESEM, and TEM images. The easy recovery of the catalyst and high yield of the products make the protocol attractive, sustainable, and economic. The catalyst was reused for six cycles with almost unaltered catalytic activity. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.02.077