5,5-diacetyl-nonane-2,8-dione

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5,5-diacetyl-nonane-2,8-dione
• 英文别名: 5,5-Diacetylnonane-2,8-dione
• 化学式: C₁₃H₂₀O₄
• 分子量: 240.299
• InChiKey: QGHSJNIUBORXRV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  68.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  丁烯酮 、 乙酰丙酮 在 作用下， 以 乙腈 为溶剂， 反应 24.0h， 以64%的产率得到5,5-diacetyl-nonane-2,8-dione
  参考文献：
  名称：

  [RuH2(PPh3)4]催化稳定碳亲核试剂的迈克尔反应

  摘要：

  缺乏氰基的活性亚甲基化合物如丙二酸酯、β-酮酯、1,3-二酮、1,1-二砜、硝基化合物、Meldrum 酸和蒽酮与常见受体的迈克尔反应在乙腈溶液中在 [RuH2 (PPh3)4]作为催化剂。氰基乙酸盐在有机溶剂中比丙二酸盐酸性更强，也是该反应的极好底物。在许多情况下，也观察到由​​ [RuH2(PPh3)4] 催化的分子内羟醛反应作为副反应。已经研究了其他钌和铑配合物的催化作用。对丙二酸和二砜供体进行的选择性研究表明，该催化剂选择性地激活可以与钌 (II) 配位的迈克尔供体。此外，已经表明该反应需要存在游离膦。所以，稳定的烯醇化物的迈克尔反应似乎是钌和膦催化的反应。从实用的角度来看，使用随手准备...

  DOI：

  10.1021/ja961373w

文献信息

• N-Heterocyclic Carbene-Catalyzed Michael Additions of 1,3-Dicarbonyl Compounds
  作者：Thomas Boddaert、Yoann Coquerel、Jean Rodriguez

  DOI：10.1002/chem.201002538

  日期：2011.2.11

  A study of the organocatalytic activity of N‐heterocyclic carbenes (NHCs) in the Michael addition of 1,3‐dicarbonyl compounds has allowed us to identify 1,3‐bis(2,6‐diisopropylphenyl)imidazol‐2‐ylidene (IPr) as an excellent catalyst for this transformation (up to 99 % yield with a 2.5 mol % catalyst loading), and the reaction was found to be of broad scope. Two early applications of this unprecedented

  对N-杂环卡宾（NHCs）在1,3-二羰基化合物的迈克尔加成反应中的有机催化活性的研究使我们能够鉴定出1,3-双（2,6-二异丙基苯基）咪唑-2-亚烷基（IPr）作为用于该转化的极好的催化剂（在2.5mol％的催化剂负载下产率高达99％），发现该反应具有广泛的范围。描述了这种NHC前所未有的催化活性的两个早期应用，即简单的环状1,3-二羰基和丙二酸衍生物的多米诺碳环化反应，它们允许立体选择进入桥接的双环化合物，以及立体选择性合成环己醇（或环己烯）。还报道了早期的机械研究。
• Quantitative aspects of base-catalyzed Michael addition: Mechanistic study of structural and medium effects on rate
  作者：John A. Markisz、Joseph D. Gettler

  DOI：10.1139/v69-319

  日期：1969.6.1

  The quantitative kinetics of the reactions of acrylonitrile and methyl vinyl ketone with ethyl acetoacetate and 2,4-pentanedione, and those of acrylonitrile with ethanol and methanol in basic solut...

  丙烯腈和甲基乙烯基酮与乙酰乙酸乙酯和2,4-戊二酮反应的定量动力学，以及丙烯腈与乙醇和甲醇在碱性溶液中反应的定量动力学...
• Photoinitiator, novel compound, and photocurable composition
  申请人：Lachowicz Artur

  公开号：US20050256218A1

  公开（公告）日：2005-11-17

  A photoinitiator is provided which exhibits excellent photosensitivity, yields colorless products, and is usable in thick layer UV curable coating. A novel chemical compound is also provided which is usable for the photoinitator. Photocurable composition is also provided which has these properties. The photoinitiator consists essentially of a compound having a molecular weight of 1000 or less, and having a chemical structure represented by the following formula (1), wherein R 3 and R 4 independently denote a specific alkyl group, and R 1 and R 2 independently denote an electron attracting group or a specific alkyl group, and weight percentage of a chemical structure element represented by the following formula (2), which is expressed in formula (1) based on the total molecular weight of the compound, is 17% to 54% by mass.

  提供了一种光引发剂，其具有优异的光敏度，产物无色，并可用于厚层紫外线固化涂层。还提供了一种新的化合物，可用于制备光引发剂。同时提供了具有这些特性的光固化组合物。该光引发剂基本上由分子量小于或等于1000的化合物组成，其化学结构由以下公式（1）表示，其中R3和R4独立地表示特定的烷基，R1和R2独立地表示电子吸引基团或特定的烷基，根据化合物的总分子量，以下公式（2）所表示的化学结构元素的重量百分比在17%至54%之间。
• Shale inhibitor and preparation method thereof, water-based drilling fluid, and shale gas drilling and extraction method
  申请人：Southwest Petroleum University

  公开号：US10287475B1

  公开（公告）日：2019-05-14

  The present invention relates to the field of shale inhibitors for drilling fluids, and discloses a shale inhibitor, a method for producing the shale inhibitor, a water-based drilling fluid, and a shale gas drilling and extraction method, wherein, the shale inhibitor contains structural units A represented by formula (I), optional structural units B represented by formula (II) and structural units C represented by formula (VIII), where, n is an integer within a range of 0-3; the shale inhibitor is an amino-terminated hyperbranched polymer; the quantity ratio of the structural units A to the structural units B to the structural units C is m:(m−1):(2m+2), wherein m is an integer within a range of 1-10. With the amino-terminated hyperbranched polymer inhibitor, the shale hydration inhibiting capability can be improved, and thereby the overall inhibition performance of a drilling fluid can be improved;

  本发明涉及钻井液用页岩抑制剂领域，公开了一种页岩抑制剂、一种页岩抑制剂的生产方法、一种水基钻井液和一种页岩气钻采方法，其中，所述页岩抑制剂含有式（I）表示的结构单元A、式（II）表示的任选结构单元B和式（VIII）表示的结构单元C，其中，n为0-3范围内的整数；页岩抑制剂为氨基封端超支化聚合物；结构单元 A 与结构单元 B 与结构单元 C 的数量比为 m：(m-1)：(2m+2)，其中m为1-10范围内的整数。使用氨基封端超支化聚合物抑制剂可以提高页岩水化抑制能力，从而改善钻井液的整体抑制性能；
• Michael addition catalyzed by difluorotris(pentafluoroethyl)phosphorane
  作者：Bożena Bittner、Karsten Koppe、Walter Frank、Nikolai Ignat’ev

  DOI：10.1016/j.jfluchem.2015.11.007

  日期：2016.2

  Difluorotris(pentafluoroethyl)phosphorane, (C2F5)(3)PF2, was found to be an active catalyst for the Michael addition reaction of 1,3-beta-diketones or beta-ketoesters (Michael donors) and linear or cyclic unsaturated ketones (Michael acceptors). The reaction proceeds under mild conditions with low catalyst loading and results in the formation of the Michael addition products in moderate to high yields. The developed protocol does not require the use of a base for the in situ generation of a carbanion (Michael donor). (C) 2015 Elsevier B.V. All rights reserved.