5-acetyl-3-dimethylamino-4-methyl-2(3H)-thiazolone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-acetyl-3-dimethylamino-4-methyl-2(3H)-thiazolone
• 英文别名: 5-Acetyl-3-(dimethylamino)-4-methyl-1,3-thiazol-2-one
• 化学式: C₈H₁₂N₂O₂S
• 分子量: 200.261
• InChiKey: CHBZFTDWPDQVSK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  65.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  pentane-2,4-dione 2-(E)-dimethylhydrazone 、 氯羰基亚磺酰氯 在 N,N-二乙基苯胺 作用下， 以 甲苯 为溶剂， 反应 10.0h， 以77%的产率得到5-acetyl-3-dimethylamino-4-methyl-2(3H)-thiazolone
  参考文献：
  名称：

  Regioselective Cyclocondensations of Chlorocarbonylsulfenyl Chloride with Hydrazones: Effective Synthesis of a Class of Sulfur and Nitrogen Containing Heterocycles with -COS- Linkage

  摘要：

  Regioselective cyclocondensations of several hydrazones with chlorocarbonylsulfenyl chloride afforded 1,3,4-(3H,6H)-thiadiazin-2-one derivatives and 3(2H)-(dimethylamino)thiazolones. The -COS- linkage was effectively incorporated into the S,N-containing heterocycles.

  DOI：

  10.3987/com-95-7242

文献信息

• Regioselective Cyclocondensations of Chlorocarbonylsulfenyl Chloride with Hydrazones: Effective Synthesis of a Class of Sulfur and Nitrogen Containing Heterocycles with -COS- Linkage
  作者：Yoo Tanabe、Kei Mori、Yoshinori Nishii

  DOI：10.3987/com-95-7242

  日期：——

  Regioselective cyclocondensations of several hydrazones with chlorocarbonylsulfenyl chloride afforded 1,3,4-(3H,6H)-thiadiazin-2-one derivatives and 3(2H)-(dimethylamino)thiazolones. The -COS- linkage was effectively incorporated into the S,N-containing heterocycles.