(4-methoxy-phenyl)-(tetra-O-methyl-β-D-glucopyranoside)

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (4-methoxy-phenyl)-(tetra-O-methyl-β-D-glucopyranoside)
• 英文别名: (4-Methoxy-phenyl)-(tetra-O-methyl-β-D-glucopyranosid)；(2R,3R,4S,5R,6S)-3,4,5-trimethoxy-2-(methoxymethyl)-6-(4-methoxyphenoxy)oxane
• 化学式: C₁₇H₂₆O₇
• 分子量: 342.389
• InChiKey: GAYCMIQNFOAAQB-NQNKBUKLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  64.6
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (4-methoxy-phenyl)-(tetra-O-methyl-β-D-glucopyranoside) 在 三乙基硅烷 、 dicobalt octacarbonyl 、 一氧化碳 、 四丁基氟化铵 作用下， 以 甲苯 、 四氢呋喃 为溶剂， 20.0~50.0 ℃ 、101.33 kPa 条件下， 反应 48.5h， 生成 、 、
  参考文献：
  名称：

  Co 2（CO）8 / Et 3 SiH / CO系统温和的糖类区域选择性去O-甲基化方法

  摘要：

  开发了一种利用Co 2（CO）8 / Et 3 SiH / CO系统从保护糖上裂解甲基醚的新方法。该方法在具有各种异头基团的不同受保护单糖中显示区域选择性。优先除去伯和赤道仲甲基醚。此方法已成功应用于高度甲基化的伊德拉帕林的DEF三糖链段的合成。

  DOI：

  10.1016/j.tet.2016.07.081
• 作为产物：
  描述：

  2,3,4,6-tetra-O-methyl-D-glucose 、 4-甲氧基苯酚 在 盐酸 、 苯 作用下， 生成 (4-methoxy-phenyl)-(tetra-O-methyl-β-D-glucopyranoside)
  参考文献：
  名称：

  Macbeth; Mackay, Journal of the Chemical Society, 1923, vol. 123, p. 717,721

  摘要：

  DOI：

文献信息

• MULTIFUNCTIONALIZED POLYETHYLENE GLYCOL DERIVATIVE AND PREPARATION METHOD THEREFOR
  申请人：XIAMEN SINOPEG BIOTECH CO., LTD.

  公开号：US20170312363A1

  公开（公告）日：2017-11-02

  Disclosed are a multifunctionalized polyethylene glycol derivative and a preparation method therefor. The derivative has an H-shaped structure as represented by formula (1) and comprises one linear core LPEG and four PEG branch chains, where n 1 , n 2 , n 3 , and n 4 respectively are the degrees of polymerization of the branch chains, U 1 and U 2 are trivalent branching groups connecting the core LPEG to two of the PEG branch chains, F 1 and F 2 contain a functional group or a protected form R 01 thereof and may or may not contain a branched group G, correspondingly, the number of R 01 is one or more, F 1 and F 2 are either identical or different, any one linking group in the molecule or any linking group formed with an adjacent heteroatom group can either remain stable or be degraded, and any one PEG segment in the molecule is discretely polydispersed or monodispersed. The multifunctional polyethylene glycol is flexible and diverse in terms of branch structures and the lengths of branching arms, has various parameters and performance indicators that are adjustable and easy to control, and has a broad applicability.
• A mild method for regioselective de-O-methylation of saccharides by Co2(CO)8/Et3SiH/CO system
  作者：Yue-tao Zhao、Lu-bai Huang、Qing Li、Zhong-jun Li

  DOI：10.1016/j.tet.2016.07.081

  日期：2016.9

  A new method for cleaving methyl ethers off protected saccharides using Co2(CO)8/Et3SiH/CO system was developed. The method showed regioselectivity in different protected monosaccharides with various anomeric groups. The primary and equatorial secondary methyl ethers were preferentially removed. This method was successfully applied to the synthesis of the DEF trisaccharide segment of Idraparinux, which

  开发了一种利用Co 2（CO）8 / Et 3 SiH / CO系统从保护糖上裂解甲基醚的新方法。该方法在具有各种异头基团的不同受保护单糖中显示区域选择性。优先除去伯和赤道仲甲基醚。此方法已成功应用于高度甲基化的伊德拉帕林的DEF三糖链段的合成。
• Macbeth; Mackay, Journal of the Chemical Society, 1923, vol. 123, p. 717,721
  作者：Macbeth、Mackay

  DOI：——

  日期：——