1-(pyridin-3-yl)-2-(2,2,2-trifluoroethoxy)ethanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(pyridin-3-yl)-2-(2,2,2-trifluoroethoxy)ethanone
• 英文别名: 1-Pyridin-3-yl-2-(2,2,2-trifluoroethoxy)ethanone；1-pyridin-3-yl-2-(2,2,2-trifluoroethoxy)ethanone
• 化学式: C₉H₈F₃NO₂
• 分子量: 219.163
• InChiKey: UUWIJGCZTSGQGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-(2-溴乙酰基)吡啶 、 2,2,2-三氟乙醇 在 caesium carbonate 作用下， 以 二乙二醇二甲醚 为溶剂， 反应 2.0h， 以15%的产率得到1-(pyridin-3-yl)-2-(2,2,2-trifluoroethoxy)ethanone
  参考文献：
  名称：

  Synthesis of α-trifluoroethoxy-substituted ketones

  摘要：

  A mild and straight-forward synthesis of alpha-trifluoroethoxy-substituted ketones from the trifluoroethoxylation of alpha-bromoketones with trifluoroethanol, under Cs2CO3-mediated conditions at room temperature, is described. The utility of this reaction for the synthesis of the trifluoroethoxy-substituted alcohols and pyrazoles is also showed. The reaction tolerates various functional groups and demonstrates efficient scalability and practicality. (C) 2015 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2015.03.009

文献信息

• Synthesis of α-trifluoroethoxy-substituted ketones
  作者：Yuguang Wang、Yi You、Zhiqiang Weng

  DOI：10.1016/j.jfluchem.2015.03.009

  日期：2015.7

  A mild and straight-forward synthesis of alpha-trifluoroethoxy-substituted ketones from the trifluoroethoxylation of alpha-bromoketones with trifluoroethanol, under Cs2CO3-mediated conditions at room temperature, is described. The utility of this reaction for the synthesis of the trifluoroethoxy-substituted alcohols and pyrazoles is also showed. The reaction tolerates various functional groups and demonstrates efficient scalability and practicality. (C) 2015 Elsevier B.V. All rights reserved.