2(R*)-Methyl-3(R*)-methoxy-1-tert-butoxypent-4-ene

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2(R*)-Methyl-3(R*)-methoxy-1-tert-butoxypent-4-ene
• 英文别名: (3S,4S)-3-methoxy-4-methyl-5-[(2-methylpropan-2-yl)oxy]pent-1-ene
• 化学式: C₁₁H₂₂O₂
• 分子量: 186.294
• InChiKey: FOPFFISEEFUYSM-UWVGGRQHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  烯丙基甲基醚 、 1(E)-Iodo-3-tert-butoxyprop-1-ene 生成 2(S*)-Methyl-3(R*)-methoxy-1-tert-butoxypent-4-ene 、 2(R*)-Methyl-3(R*)-methoxy-1-tert-butoxypent-4-ene
  参考文献：
  名称：

  Diastereoselective Carbometalation of Vinyl Metals

  摘要：

  The allylzincation of vinylmetals is a very general reaction; whatever the nature of the vinyl organometallics, the reaction occurs with 1 equiv of substituted allylmagnesium bromide, if 1 equiv of zinc salt is present. This new synthetic approach leads to the creation of stereogenic secondary carbon centers with an excellent level of stereocontrol.

  DOI：

  10.1021/jo00094a028

文献信息

• Diastereoselective Carbometalation of Vinyl Metals
  作者：Ilane Marek、Jean-Michel Lefrancois、Jean-F. Normant

  DOI：10.1021/jo00094a028

  日期：1994.7

  The allylzincation of vinylmetals is a very general reaction; whatever the nature of the vinyl organometallics, the reaction occurs with 1 equiv of substituted allylmagnesium bromide, if 1 equiv of zinc salt is present. This new synthetic approach leads to the creation of stereogenic secondary carbon centers with an excellent level of stereocontrol.