N³-(iso-butyl)-2-methyl-4-(2-oxo-2-phenylethyl)-5-phenyl-3-furamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N³-(iso-butyl)-2-methyl-4-(2-oxo-2-phenylethyl)-5-phenyl-3-furamide
• 英文别名: 2-methyl-N-(2-methylpropyl)-4-phenacyl-5-phenylfuran-3-carboxamide
• 化学式: C₂₄H₂₅NO₃
• 分子量: 375.467
• InChiKey: GJJGJXDAUJHZIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  59.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  双乙烯酮 、 异丁胺 、 二苯甲酰基乙炔 在 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 以87%的产率得到N³-(iso-butyl)-2-methyl-4-(2-oxo-2-phenylethyl)-5-phenyl-3-furamide
  参考文献：
  名称：

  One-pot synthesis of functionalized furamide derivatives via a three-component reaction between an amine, diketene and dibenzoylacetylene in the presence of triphenylphosphine

  摘要：

  An effective route to functionalized furamide derivatives is described. This involves reaction of N-alkyl-3-oxobutanamides, derived from the addition of amines to the diketene, and dibenzoylacetylene in the presence of triphenylphosphoine. The reactive 1:1 intermediate obtained from the addition of triphenylphosphine to dibenzoylacetylene was trapped by OH-acids such as N-alkyl-3-oxobutanamide to produce functionalized furamide derivatives. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.06.021

文献信息

• One-pot synthesis of functionalized furamide derivatives via a three-component reaction between an amine, diketene and dibenzoylacetylene in the presence of triphenylphosphine
  作者：Abdolali Alizadeh、Nasrin Zohreh、Sadegh Rostamnia

  DOI：10.1016/j.tet.2007.06.021

  日期：2007.8

  An effective route to functionalized furamide derivatives is described. This involves reaction of N-alkyl-3-oxobutanamides, derived from the addition of amines to the diketene, and dibenzoylacetylene in the presence of triphenylphosphoine. The reactive 1:1 intermediate obtained from the addition of triphenylphosphine to dibenzoylacetylene was trapped by OH-acids such as N-alkyl-3-oxobutanamide to produce functionalized furamide derivatives. (c) 2007 Elsevier Ltd. All rights reserved.