2-[[2-phenyl-1-thioxoethyl]thio]propanoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[[2-phenyl-1-thioxoethyl]thio]propanoic acid
• 英文别名: 2-[(2-phenylethanethioyl)sulfanyl]propanoic Acid；2-(2-phenylethanethioyl)sulfanylpropanoic acid
• 化学式: C₁₁H₁₂O₂S₂
• 分子量: 240.347
• InChiKey: FPIRKEFSFDLXPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  94.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  二硫化碳 、 苄基溴化镁 、 2-溴丙酸 以 四氢呋喃 、 乙醚 为溶剂， 反应 48.5h， 以39%的产率得到2-[[2-phenyl-1-thioxoethyl]thio]propanoic acid
  参考文献：
  名称：

  通过RAFT聚合的双取代的丙烯酰胺衍生物的分子量和官能端基控制

  摘要：

  双取代的丙烯酰胺衍生物N-丙烯酰基吗啉（NAM）的受控自由基聚合具有产生远螯聚合物的潜力，该聚合物的一端随后可以接枝到胶乳颗粒上。接枝后，聚合物的另一链端可用作分子生物学和生物医学中应用的固定化位点。使用两个带有相同官能丙酸基团（R）和两个不同Z基团的新链转移剂S C（Z）-SR进行可逆加成-断裂链转移（RAFT）的NAM受控聚合（CTA 1 ）和苯基（CTA 2）。由CTA 1介导的NAM的RAFT聚合反应非常快（在65°C下不到半小时的转化率> 80％）。M̄的线性演化Ñ和低的多分散指数（中号瓦特/中号Ñ <1.2）与活性聚合的期待的特性一致。CTA 2导致M w w / M n宽（<1.4）。所得的CTA封端的聚合物进一步用于产生两亲性的polyNAM-嵌段-聚苯乙烯。这些α，ω-官能化的polyNAM链通过1 H NMR和MALDI-ToF质谱法表征。

  DOI：

  10.1021/ma025646l

文献信息

• POLYMER PARTICLES
  申请人：Hawkett Brian Stanley

  公开号：US20120128743A1

  公开（公告）日：2012-05-24

  The present invention relates to a method of forming polymer on the surface of polymer particles, the method comprising: (i) providing a dispersion comprising a continuous aqueous phase, a dispersed organic phase comprising one or more ethylenically unsaturated monomers, and a RAFT agent as a stabiliser for said organic phase; (ii) polymerising the one or more ethylenically unsaturated monomers under the control of the RAFT agent to form an aqueous dispersion of seed polymer particles; (iii) crosslinking the seed polymer particles; (iv) swelling the crosslinked seed particles with one or more ethylenically unsaturated monomers to form an aqueous dispersion of monomer swollen crosslinked seed polymer particles; (v) increasing the temperature of the monomer swollen crosslinked seed polymer particles to expel at least some of the monomer therein onto the surface of the particles; and polymerising at least the expelled monomer to form polymer on the surface of the particles.

  本发明涉及一种在聚合物颗粒表面形成聚合物的方法，该方法包括：(i)提供一个分散体系，该分散体系包括连续的水相、分散的有机相，该有机相包括一种或多种乙烯基不饱和单体以及RAFT剂作为有机相的稳定剂；(ii)在RAFT剂的控制下聚合一种或多种乙烯基不饱和单体，形成种子聚合物颗粒的水性分散体系；(iii)交联种子聚合物颗粒；(iv)用一种或多种乙烯基不饱和单体膨胀交联的种子颗粒，形成乙烯基不饱和单体膨胀交联种子聚合物颗粒的水性分散体系；(v)提高乙烯基不饱和单体膨胀交联种子聚合物颗粒的温度，使其中至少一部分乙烯基不饱和单体排出到颗粒表面；并聚合至少被排出的乙烯基不饱和单体，在颗粒表面形成聚合物。
• Aqueous dispersions of polymer particles
  申请人：Such Henry Christopher

  公开号：US20060223936A1

  公开（公告）日：2006-10-05

  The invention provides a method for preparing an aqueous dispersion of polymer particles comprising the following steps: (i) preparing a dispersion having a continuous aqueous phase, a dispersed organic phase comprising one or more ethylenically unsaturated monomers, and an amphiphilic RAFT agent as a stabiliser for said organic phase, and (ii) polymerising said one or more ethylenically unsaturated monomers under the control of said amphiphilic RAFT agent to form said aqueous dispersion of polymer particles, novel amphiphilic RAFT agents for use in this method, novel RAFT agents useful in making these amphiphilic RAFT agents and methods for their manufacture.

  本发明提供了一种制备聚合物颗粒水分散液的方法，包括以下步骤：(i)制备一个连续的水相分散体系，其中包括一个或多个乙烯基不饱和单体的分散有机相，并且含有一种两亲性RAFT剂作为有机相的稳定剂，以及(ii)在该两亲性RAFT剂的控制下聚合该一种或多种乙烯基不饱和单体，以形成所述聚合物颗粒的水分散液，以及在该方法中使用的新型两亲性RAFT剂，用于制备这些两亲性RAFT剂的新型RAFT剂和它们的制备方法。
• AQUEOUS DISPERSIONS OF POLYMER PARTICLES
  申请人：SUCH Christopher Henry

  公开号：US20100227975A1

  公开（公告）日：2010-09-09

  The invention provides a method for preparing an aqueous dispersion of polymer particles comprising the following steps: (i) preparing a dispersion having a continuous aqueous phase, a dispersed organic phase comprising one or more ethylenically unsaturated monomers, and an amphiphilic RAFT agent as a stabiliser for said organic phase, and (ii) polymerising said one or more ethylenically unsaturated monomers under the control of said amphiphilic RAFT agent to form said aqueous dispersion of polymer particles, novel amphiphilic RAFT agents for use in this method, novel RAFT agents useful in making these amphiphilic RAFT agents and methods for their manufacture.

  本发明提供了一种制备聚合物颗粒水分散液的方法，包括以下步骤：(i)制备一种具有连续水相、分散的有机相，其中包括一种或多种乙烯基不饱和单体，以及一种防止有机相稳定剂的亲疏性RAFT剂，(ii)在亲疏性RAFT剂的控制下聚合所述一种或多种乙烯基不饱和单体，以形成所述聚合物颗粒的水分散液。本发明还提供了用于该方法的新型亲疏性RAFT剂，用于制备这些亲疏性RAFT剂的新型RAFT剂以及其制造方法。
• Polymer obtained by the use of RAFT-agents and process of encapsulating of particulate material by said polymer.
  申请人：The University of Sydney

  公开号：EP2172491A1

  公开（公告）日：2010-04-07

  Polymer encapsulated particulate material that is 100 microns or less in size, wherein: (a) said particulate material is encapsulated in a substantially uniform and continuous coating of a polymer which has at least in part been formed under the control of a RAFT agent; or (b) the polymer which encapsulates the particulate material has at least in part been formed under the control of a RAFT agent, and wherein the particulate material is substantially uniformly dispersed throughout the polymer.

  尺寸为 100 微米或更小的聚合物封装微粒材料，其中 (a) 上述微粒材料被封装在聚合物的基本均匀和连续的涂层中，该聚合物至少有一部分是在 RAFT 剂的控制下形成的；或 (b) 封装微粒材料的聚合物至少有一部分是在 RAFT 剂的控制下形成的，其中微粒材料基本上均匀地分散在整个聚合物中。
• Polymer product formed using raft agent
  申请人：The University of Sydney

  公开号：EP2363419A1

  公开（公告）日：2011-09-07

  The invention provides polymer encapsulated solid particulate material that is 100 microns or less in size, wherein: (a) said solid particulate material is encapsulated in a substantially uniform and continuous coating of a polymer that has at least in part been formed under the control of a hydrophilic RAFT agent; or (b) the encapsulating polymer has at least in part been formed under the control of a hydrophilic RAFT agent, and wherein the solid particulate material is substantially uniformly dispersed throughout the encapsulating polymer. The invention also provides related compositions, paints, fillers, adhesives, primers, toners, liquid inks, sealants, diagnostic products, therapeutic products and liquid dispersions.

  本发明提供尺寸为 100 微米或更小的聚合物封装固体颗粒材料，其中： (a) 所述固体颗粒材料被封装在聚合物的基本均匀和连续的涂层中，该聚合物至少有一部分是在亲水性 RAFT 剂的控制下形成的；或 (b) 封装聚合物至少有一部分是在亲水性 RAFT 剂的控制下形成的，其中固 体颗粒材料基本上均匀地分散在整个封装聚合物中。 本发明还提供了相关的组合物、涂料、填料、粘合剂、底漆、调色剂、液体油墨、密封剂、诊断产品、治疗产品和液体分散体。