styrene

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: styrene
• 英文别名: methyl 2,6-dichlorocinnamate；Methyl 3-(2,6-dichlorophenyl)acrylate；methyl 3-(2,6-dichlorophenyl)prop-2-enoate
• 化学式: C₁₀H₈Cl₂O₂
• 分子量: 231.078
• InChiKey: ZNJMTZNUYPTNLN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  styrene 在 二异丁基氢化铝 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 生成 3-(2.6-Dichlor-phenyl)-prop-2-en-1-ol
  参考文献：
  名称：

  Catalytic asymmetric bromochlorination of aromatic allylic alcohols promoted by multifunctional Schiff base ligands

  摘要：

  直接给您结果： 在烯丙醇的催化不对称溴氯化反应中，获得了具有两个溴/氯连接的碳立体异构中心的芳香溴氯醇，其立体选择性从中等到优异，产率和化学选择性也很好。

  DOI：

  10.1039/c6ob01306f
• 作为产物：
  描述：

  丙烯酸甲酯（MA） 、 2,6-dichlorobenzenediazonium tetrafluoroborate 以 乙醇 为溶剂， 反应 24.0h， 以90%的产率得到styrene
  参考文献：
  名称：

  Mizoroki–Heck coupling reactions of arenediazonium tetrafluoroborate salts catalyzed by aluminium hydroxide-supported palladium nanoparticles

  摘要：

  Mizoroki-Heck cross-couplings of arenediazonium tetrafluoroborate salts catalyzed by highly active aluminium hydroxide-supported palladium nanoparticles catalyst have been investigated for the first time. The reactions are performed at 25 degrees C in EtOH without any base and ligand to afford the corresponding coupling products in good to excellent yields under non-anhydrous and non-degassed conditions. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.apcata.2013.04.009

文献信息

• One-pot stereoselective synthesis of α,β-differentiated diamino esters via the sequence of aminochlorination, aziridination and intermolecular S_N2 reaction
  作者：Yiwen Xiong、Ping Qian、Chenhui Cao、Haibo Mei、Jianlin Han、Guigen Li、Yi Pan

  DOI：10.3762/bjoc.10.189

  日期：——

  We report here an efficient one-pot method for the synthesis of alpha,beta-differentiated diamino esters directly from cinnamate esters using N,N-dichloro-p-toluenesulfonamide and benzylamine as nitrogen sources. The key transformations include a Cu-catalyzed aminohalogenation and aziridination, followed by an intermolecular SN2 nucleophilic ring opening by benzylamine. The reactions feature a wide

  我们在这里报告了一种有效的单锅法，用于使用 N，N-二氯-对甲苯磺酰胺和苄胺作为氮源直接从肉桂酸酯合成 α、β 分化的二氨基酯。关键的转变包括铜催化的氨基卤化和氮丙啶化，然后是苄胺的分子间 SN2 亲核开环。该反应具有广泛的底物范围，并具有出色的立体选择性和区域选择性（anti:syn > 99:1）。
• Bream; Lauener; Picard, Arzneimittel-Forschung/Drug Research, 1975, vol. 25, # 10, p. 1477 - 1482
  作者：Bream、Lauener、Picard、Scholtysik、White

  DOI：——

  日期：——
• Catalytic asymmetric bromochlorination of aromatic allylic alcohols promoted by multifunctional Schiff base ligands
  作者：Wei-Sheng Huang、Li Chen、Zhan-Jiang Zheng、Ke-Fang Yang、Zheng Xu、Yu-Ming Cui、Li-Wen Xu

  DOI：10.1039/c6ob01306f

  日期：——

  The aromatic bromochloroalcohols with two bromide/chloride-linked carbon-stereogenic centers were obtained in moderate to excellent regio- and enantioselectivities as well as good yields and chemoselectivities in the catalytic asymmetric bromochlorination of allylic alcohols.

  直接给您结果： 在烯丙醇的催化不对称溴氯化反应中，获得了具有两个溴/氯连接的碳立体异构中心的芳香溴氯醇，其立体选择性从中等到优异，产率和化学选择性也很好。
• Mizoroki–Heck coupling reactions of arenediazonium tetrafluoroborate salts catalyzed by aluminium hydroxide-supported palladium nanoparticles
  作者：Xing Li、Li-Chao Wang、Hong-Hong Chang、Cong-Xia Zhang、Wen-Long Wei

  DOI：10.1016/j.apcata.2013.04.009

  日期：2013.7

  Mizoroki-Heck cross-couplings of arenediazonium tetrafluoroborate salts catalyzed by highly active aluminium hydroxide-supported palladium nanoparticles catalyst have been investigated for the first time. The reactions are performed at 25 degrees C in EtOH without any base and ligand to afford the corresponding coupling products in good to excellent yields under non-anhydrous and non-degassed conditions. (C) 2013 Elsevier B.V. All rights reserved.