N-(3-chlorophenyl)-10H-indolo[3,2-b]quinolin-11-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-(3-chlorophenyl)-10H-indolo[3,2-b]quinolin-11-amine
• 化学式: C₂₁H₁₄ClN₃
• 分子量: 343.815
• InChiKey: CSBNNYKSNCEJRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  40.7
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-chloroacetamidobenzoic acid 在 盐酸 、 三氟化硼乙醚 、 三氯氧磷 作用下， 以 乙二醇乙醚 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 生成 N-(3-chlorophenyl)-10H-indolo[3,2-b]quinolin-11-amine
  参考文献：
  名称：

  Structure–activity relationship of indoloquinoline analogs anti-MRSA

  摘要：

  Indolo[3,2-b]quinoline analogs (3a-3s), 4-(acridin-9-ylamino) phenol hydrochloride (4), benzofuro[3,2-b]quinoline (3t), indeno[1,2-b] quinolines (3u and 3v) have been synthesized. Those compounds were found to exhibit anti-bacterial activity towards Methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Structure-activity relationship studies were conducted that indoloquinoline ring, benzofuro-quinoline ring and 4-aminophenol group are essential structure for anti-MRSA activity. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2015.10.058

文献信息

• Design, Synthesis, and Antimicrobial Activity of Quindoline Derivatives Inspired by the Cryptolepine Alkaloid
  作者：Qing-Ru Chu、Ying-Hui He、Chen Tang、Zhi-Jun Zhang、Xiong-Fei Luo、Bao-Qi Zhang、Yong Zhou、Tian-Lin Wu、Sha-Sha Du、Cheng-Jie Yang、Ying-Qian Liu

  DOI：10.1021/acs.jafc.1c07536

  日期：2022.3.9
• Structure–activity relationship of indoloquinoline analogs anti-MRSA
  作者：Min Zhao、Tomonori Kamada、Aya Takeuchi、Hiromi Nishioka、Teruo Kuroda、Yasuo Takeuchi

  DOI：10.1016/j.bmcl.2015.10.058

  日期：2015.12

  Indolo[3,2-b]quinoline analogs (3a-3s), 4-(acridin-9-ylamino) phenol hydrochloride (4), benzofuro[3,2-b]quinoline (3t), indeno[1,2-b] quinolines (3u and 3v) have been synthesized. Those compounds were found to exhibit anti-bacterial activity towards Methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Structure-activity relationship studies were conducted that indoloquinoline ring, benzofuro-quinoline ring and 4-aminophenol group are essential structure for anti-MRSA activity. (C) 2015 Elsevier Ltd. All rights reserved.