3-hexanoylpyrrolidine-2,5-dione

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-hexanoylpyrrolidine-2,5-dione
• 化学式: C₁₀H₁₅NO₃
• 分子量: 197.234
• InChiKey: CGXWLLMOZBHPGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  63.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  马来酰亚胺 、 正己醛 在 2-pentafluorophenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate 、 N,N-二异丙基乙胺 作用下， 以 甲苯 为溶剂， 反应 24.5h， 以91%的产率得到3-hexanoylpyrrolidine-2,5-dione
  参考文献：
  名称：

  通过3-酰基琥珀酰亚胺的动态动力学拆分立体发散性合成手性对conconconic酸。

  摘要：

  建立具有烷基醛的马来酰亚胺的直接N-杂环卡宾（NHC）催化，以合成3-酰基琥珀酰亚胺。3-酰基琥珀酰亚胺的第一动态动力学拆分是通过不对称转移氢化实现的。这两种催化方法被用于以三个步骤合成反式-对conconic酸的每个对映异构体和以四个步骤来合成顺式-对conconconic酸，具有良好的收率和高的立体选择性。这种立体发散的合成方法可用于合成七种生物活性对锥酸天然产物。

  DOI：

  10.1021/acs.orglett.9b01445

文献信息

• Methods of making and using surfactant polymers
  申请人：Marchant E. Roger

  公开号：US20050008603A1

  公开（公告）日：2005-01-13

  Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional groups for coupling with side chains, a plurality of hydrophobic side chains linked to said backbone via the functional groups, and a plurality of hydrophilic side chains linked to said backbone via the functional groups. The hydrophobic side chains comprise an alkyl group comprising from 2 to 18 methylene groups. The alkyl groups are linked to the polymeric backbone through ester linkages, secondary amine linkages, or, preferably, amide linkages. The hydrophilic side chain is selected from the group consisting of: a neutral oligosaccharide, which, preferably, has weight average molecular weight of less than 7000; a charged oligosaccharide, preferably a negatively charged oligosaccharide having a weight average molecular weight of less than 10,000; an oligopeptide of from about 3 to about 30 amino acid residues, said oligopeptide having an amino acid sequence which interacts with protein receptors on the surface of cells; and combinations thereof. Methods of making the surfactant polymers and using the surfactant polymers to alter the surface properties of a biomaterial are also provided.

  提供了用于改变生物材料表面性质的类似梳子的表面活性聚合物。这种表面活性聚合物包括具有用于与侧链偶联的功能基团的重复单体单位的聚合骨架，通过功能基团连接到该骨架的多个疏水侧链，以及通过功能基团连接到该骨架的多个亲水侧链。疏水侧链包括包含从2到18个亚甲基团的烷基团。烷基团通过酯键、次胺键或者更好地，酰胺键连接到聚合骨架上。亲水侧链选自以下组合中的一种：中性寡糖，最好的情况下，其重均分子量小于7000；带电寡糖，最好是重均分子量小于10000的带负电寡糖；由大约3到大约30个氨基酸残基组成的寡肽，该寡肽具有与细胞表面蛋白受体相互作用的氨基酸序列；以及它们的组合。还提供了制备表面活性聚合物和使用表面活性聚合物改变生物材料表面性质的方法。
• METHODS OF MAKING AND USING SURFACTANT POLYMERS
  申请人：MARCHANT Roger E.

  公开号：US20080262614A1

  公开（公告）日：2008-10-23

  Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional groups for coupling with side chains, a plurality of hydrophobic side chains linked to the backbone via the functional groups, and a plurality of hydrophilic side chains linked to said backbone via the functional groups. Medical devices coated with the surfactant polymers are also provided. The surfactant polymers may be used to decrease the thrombogenic properties, encapsulation, and bacterial colonization of medical devices.

  提供了一种用于改变生物材料表面性质的类梳状表面活性聚合物。这种表面活性聚合物包括具有与侧链耦合的功能基团的重复单体单元的聚合骨架，通过功能基团连接到骨架的多个亲水性侧链和多个疏水性侧链。还提供了涂有表面活性聚合物的医疗器械。表面活性聚合物可用于减少医疗器械的血栓形成性能、封装和细菌定植。
• Methods of Making and Using Surfactant Polymers
  申请人：NanoMimetics, Inc.

  公开号：EP2106812A2

  公开（公告）日：2009-10-07

  Comblike, surfactant polymers for changing the surface properties of biomaterials and methods of preparation thereof are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional groups for coupling with side chains, a plurality of hydrophobic side chains linked to the backbone via the functional groups, and a plurality of hydrophilic side chains linked to the backbone via the functional groups. Medical devices coated with the surfactant polymers are also provided. The surfactant polymers may be used to decrease the thrombogenic properties, encapsulation, and bacterial colonization of medical devices.

  本发明提供了可改变生物材料表面性质的表面活性剂聚合物及其制备方法。这种表面活性剂聚合物包括一个由重复单体单元组成的聚合物主链，该单体单元具有用于与侧链偶联的官能团，多个疏水侧链通过官能团与主链相连，多个亲水侧链通过官能团与主链相连。此外，还提供了涂有表面活性剂聚合物的医疗器械。表面活性剂聚合物可用于降低医疗器械的血栓形成特性、封装和细菌定植。
• SURFACTANTS THAT MIMIC THE GLYCOCALYX
  申请人：Marchant, Roger E.

  公开号：EP1086149A1

  公开（公告）日：2001-03-28
• EP1086149A4
  申请人：——

  公开号：EP1086149A4

  公开（公告）日：2002-10-30