2,2-dimethyl-5,5-bis-(3-methyl-2-methylene-but-3-enyl)-[1,3]dioxane-4,6-dione

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2-dimethyl-5,5-bis-(3-methyl-2-methylene-but-3-enyl)-[1,3]dioxane-4,6-dione
• 英文别名: 2,2-Dimethyl-5,5-bis(3-methyl-2-methylidenebut-3-enyl)-1,3-dioxane-4,6-dione；2,2-dimethyl-5,5-bis(3-methyl-2-methylidenebut-3-enyl)-1,3-dioxane-4,6-dione
• 化学式: C₁₈H₂₄O₄
• 分子量: 304.386
• InChiKey: JDOIFWWBCZIEMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-甲基马来酰亚胺 、 2,2-dimethyl-5,5-bis-(3-methyl-2-methylene-but-3-enyl)-[1,3]dioxane-4,6-dione 以 四氢呋喃 为溶剂， 反应 18.0h， 以64%的产率得到2,2-dimethyl-5,5-bis-(2,6-dimethyl-1,3-dioxo-2,3,3a,4,7,7a-hexahydro-1H-isoindol-5-ylmethyl)-[1,3]-dioxane-4,6-dione
  参考文献：
  名称：

  Palladium catalysed reactions of allene with active methylene pronucleophiles. C-1,3-Dienylmethyl derivatives and their Diels–Alder reactions

  摘要：

  A 2-step 100% atom economic sequence is reported whereby active methylene pronucleophiles react with 2 mol equiv. of allene to give bis-1,3-dienylmethyl derivatives of the pronucleophiles. Subsequent double Diels-Alder reactions furnish 1,1'-linked cyclohexenes with a 3-carbon spacer. (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(01)00924-3
• 作为产物：
  描述：

  丙二酸环(亚)异丙酯 、 丙二烯 在 四(三苯基膦)钯 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 以61%的产率得到2,2-dimethyl-5,5-bis-(3-methyl-2-methylene-but-3-enyl)-[1,3]dioxane-4,6-dione
  参考文献：
  名称：

  Palladium catalysed reactions of allene with active methylene pronucleophiles. C-1,3-Dienylmethyl derivatives and their Diels–Alder reactions

  摘要：

  A 2-step 100% atom economic sequence is reported whereby active methylene pronucleophiles react with 2 mol equiv. of allene to give bis-1,3-dienylmethyl derivatives of the pronucleophiles. Subsequent double Diels-Alder reactions furnish 1,1'-linked cyclohexenes with a 3-carbon spacer. (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(01)00924-3

文献信息

• Palladium catalysed reactions of allene with active methylene pronucleophiles. C-1,3-Dienylmethyl derivatives and their Diels–Alder reactions
  作者：Ronald Grigg、Ngampong Kongathip、Boonsang Kongathip、Suwaporn Luangkamin、H.Ali Dondas

  DOI：10.1016/s0040-4020(01)00924-3

  日期：2001.10

  A 2-step 100% atom economic sequence is reported whereby active methylene pronucleophiles react with 2 mol equiv. of allene to give bis-1,3-dienylmethyl derivatives of the pronucleophiles. Subsequent double Diels-Alder reactions furnish 1,1'-linked cyclohexenes with a 3-carbon spacer. (C) 2001 Published by Elsevier Science Ltd.