fluorenyl-4-hydroxybenzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: fluorenyl-4-hydroxybenzoate
• 英文别名: 9H-fluoren-9-yl 4-hydroxybenzoate
• 化学式: C₂₀H₁₄O₃
• 分子量: 302.329
• InChiKey: CYDYVVFQESZGFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  对羟基苯甲酸 、 9-重氮基-9H-芴 以 乙腈 为溶剂， 反应 10.0h， 以85%的产率得到fluorenyl-4-hydroxybenzoate
  参考文献：
  名称：

  Diazo compounds for the bioreversible esterification of proteins

  摘要：

  一种重氮化合物被证明可以在水性环境中高效地将羧酸转化为酯。

  DOI：

  10.1039/c4sc01768d

文献信息

• Reagents and methods for esterification
  申请人：Wisconsin Alumni Research Foundation

  公开号：US10577303B1

  公开（公告）日：2020-03-03

  A method for esterification of one or more carboxylic acid groups in a compound containing one or more carboxylic acid groups wherein the esterification reagent is a diazo-compound of formula: wherein the R1 and R2 groups of the diazo compound are selected such that the corresponding organic compound of formula: exhibits a —C—H pKa value between 18 and 29 as measured in DMSO. Specific reagents and methods for esterification are provided. The esterification reagents provided exhibit high selectivity for esterification of carboxylic acid groups over reaction with amine, alcohol or thiol groups in the compound containing one or more carboxylic acid groups. The method can be used to selectively esterify carboxylic acid groups in peptides or proteins.

  一种酯化方法，用于含有一个或多个羧酸基团的化合物中一个或多个羧酸基团的酯化，其中酯化试剂是具有以下结构的重氮化合物： 其中重氮化合物的R1和R2基团被选择为使相应的有机化合物具有在DMSO中测得的—C—H pKa值在18和29之间。提供了用于酯化的特定试剂和方法。所提供的酯化试剂对含有一个或多个羧酸基团的化合物中的羧酸基团的酯化表现出高选择性，而不与胺基、醇基或硫醇基反应。该方法可用于选择性地酯化肽或蛋白质中的羧酸基团。
• Reagents and Methods for Esterification
  申请人：Wisconsin Alumni Research Foundation

  公开号：US20200190011A1

  公开（公告）日：2020-06-18

  A method for esterification of one or more carboxylic acid groups in a compound containing one or more carboxylic acid groups wherein the esterification reagent is a diazo-compound of formula: wherein the R 1 and R 2 groups of the diazo compound are selected such that the corresponding organic compound of formula: exhibits a —C—H pKa value between 18 and 29 as measured in DMSO. Specific reagents and methods for esterification are provided. The esterification reagents provided exhibit high selectivity for esterification of carboxylic acid groups over reaction with amine, alcohol or thiol groups in the compound containing one or more carboxylic acid groups. The method can be used to selectively esterify carboxylic acid groups in peptides or proteins.
• Diazo compounds for the bioreversible esterification of proteins
  作者：Nicholas A. McGrath、Kristen A. Andersen、Amy K. F. Davis、Jo E. Lomax、Ronald T. Raines

  DOI：10.1039/c4sc01768d

  日期：——

  A diazo compound is shown to convert carboxylic acids to esters efficiently in an aqueous environment.

  一种重氮化合物被证明可以在水性环境中高效地将羧酸转化为酯。