六乙二醇二甲醚 | 1072-40-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 六乙二醇二甲醚
• 英文名称: 2,5,8,11,14,17,20-heptaoxahenicosane
• 英文别名: hexaethylene glycol dimethyl ether；hexaethylene glycol dimethylether；1,17-dimethoxy-3,6,9,12,15-pentaoxa-heptadecane；bis-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethyl} ether；1,17-Dimethoxy-3,6,9,12,15-pentaoxa-heptadecan；O,O'-Dimethyl-hexaaethylenglykol；1-methoxy-2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethane
• CAS: 1072-40-8
• 化学式: C₁₄H₃₀O₇
• 分子量: 310.388
• InChiKey: VMCIKMLQXFLKAX-UHFFFAOYSA-N

物化性质

• 沸点：
  359.0±37.0 °C(Predicted)
• 密度：
  1.020±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于氯仿（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  21
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  64.6
• 氢给体数：
  0
• 氢受体数：
  7

安全信息

• 海关编码：
  2901100000
• 储存条件：
  存放温度应保持在2-8℃，需干燥并密封。

制备方法与用途

六亚甲基甘醇二乙醚是一种PROTAC连接子，属于PEG类化合物，可用来合成PROTAC分子。

反应信息

• 作为反应物：
  描述：

  六乙二醇二甲醚 在 barium 作用下， 以 乙腈 为溶剂， 生成
  参考文献：
  名称：

  乙腈对含不同给体原子的冠醚络合物形成的影响

  摘要：

  通过量热滴定和电位滴定研究了冠醚与一价阳离子和 Ba2+ 在乙腈溶液中的络合反应。测量的反应焓清楚地证明了 18-crown-6 和乙腈溶剂分子之间相互作用的影响。改变配体分子上的供体原子或其他取代基会对与溶剂的相互作用产生强烈影响。因此，与 18-crown-6 相比，15-crown-5 与不同阳离子的反应测得的所有反应焓都更高。通过与甲醇中的结果进行比较，对溶剂分子对乙腈中测量的反应焓的影响进行了近似估计。由于银离子与乙腈之间有很强的相互作用，

  DOI：

  10.1007/bf00646180
• 作为产物：
  描述：

  三甘醇单甲醚 在 吡啶 、 氯化亚砜 作用下， 生成 六乙二醇二甲醚
  参考文献：
  名称：

  Constantes d'association de quelques éthers de polyéthyléne glycols avec Na⁺, K⁺, Cs⁺et Tl⁺

  摘要：

  我们报告了关于我们制备的一些聚乙二醇醚与一价阳离子的关联数据。在25°C下，使用选择性玻璃电极电位测量获得了甲醇中Na^{+和K+的1:1结合常数K_A，并使用Cs+和Tl+的电导测量获得。对于K_A以及选择比K_A(K+)/K_A(Na+)的数值随着配位位点数量的增加而增加。通过将链中的两个甲氧基末端基团替换为主要酰胺或酯基团，可以降低配体的络合性能。在一些联苯聚醚的情况下，讨论了配位的立体化学。}

  DOI：

  10.1139/v75-314

文献信息

• CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME
  申请人：Arvinas, Inc.

  公开号：US20180215731A1

  公开（公告）日：2018-08-02

  The description relates to cereblon E3 ligase binding compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present disclosure. In particular, the description provides compounds, which contain on one end a ligand which binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacological activities consistent with the degradation/inhibition of targeted polypeptides of nearly any type.

  该描述涉及cereblon E3连接酶结合化合物，包括包含相同成分的双功能化合物，这些化合物作为靶向泛素化的调节剂具有实用价值，尤其是抑制剂，可降解和/或以其他方式抑制根据本公开的双功能化合物。特别是，该描述提供了化合物，其一端含有与cereblon E3泛素连接酶结合的配体，另一端含有与目标蛋白结合的部分，使目标蛋白位于泛素连接酶附近以降解（和抑制）该蛋白。可以合成表现出广泛药理活性的化合物，与几乎所有类型的靶向多肽的降解/抑制一致。
• COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES
  申请人：Arvinas, Inc.

  公开号：US20180179183A1

  公开（公告）日：2018-06-28

  The present disclosure relates to bifunctional compounds, which find utility as modulators of Rapidly Accelerated Fibrosarcoma (RAF, such as c-RAF, A-RAF and/or B-RAF; the target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein RAF, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein, or the constitutive activation of the target protein, are treated or prevented with compounds and compositions of the present disclosure.

  本公开涉及双功能化合物，其作为快速加速纤维肉瘤（RAF，如c-RAF、A-RAF和/或B-RAF；目标蛋白）的调节剂而发挥作用。具体而言，本公开涉及含有一端为Von Hippel-Lindau、cereblon、凋亡抑制蛋白或鼠双分子同源物2配体的双功能化合物，该配体与相应的E3泛素连接酶结合，并且另一端含有结合目标蛋白RAF的基团，使得目标蛋白与泛素连接酶靠近，以实现目标蛋白的降解（和抑制）。本公开展示了与目标蛋白的降解/抑制相关的广泛药理活性范围。本公开的化合物和组合物用于治疗或预防由目标蛋白的聚集或积累，或目标蛋白的构成性激活导致的疾病或紊乱。
• Process for the preparation of cyclic esters and method for purification of the same
  申请人：——

  公开号：US20030191326A1

  公开（公告）日：2003-10-09

  The present invention provides a process for production of a cyclic ester by depolymerization of an aliphatic polyester. In the process, a mixture containing the aliphatic polyester and a specific polyalkylene glycol ether, which has a boiling point of 230-450° C. and a molecular weight of 150-450, is heated under normal or reduced pressure to a temperature at which depolymerization of the aliphatic polyester takes place. Then, a substantially homogeneous solution phase, consisting of the melt phase of the aliphatic polyester and the liquid phase of the polyalkylene glycol ether, is formed. Heating of the solution phase is continued to form the cyclic ester by depolymerization and distil out the cyclic ester together with the polyalkylene glycol ether, and then the cyclic ester is recovered from the distillate. The present invention also provides a process for purification of a crude cyclic ester by use of the specific polyalkylene glycol ether described above.

  本发明提供了一种通过脂肪族聚酯的降解来生产环酯的方法。在该过程中，将含有脂肪族聚酯和具有沸点在230-450°C和分子量在150-450之间的特定聚烷基乙二醇醚的混合物，在常压或减压下加热至脂肪族聚酯发生降解的温度。然后，形成由脂肪族聚酯的熔融相和聚烷基乙二醇醚的液相组成的基本均相溶液相。继续加热溶液相以通过降解形成环酯并与聚烷基乙二醇醚一起蒸馏出环酯，然后从馏出物中回收环酯。本发明还提供了一种利用上述特定聚烷基乙二醇醚对粗环酯进行纯化的方法。
• COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ENHANCER OF ZESTE HOMOLOG 2 POLYPEPTIDE
  申请人：Arvinas, Inc.

  公开号：US20180177750A1

  公开（公告）日：2018-06-28

  The present disclosure relates to bifunctional compounds, which find utility as modulators of enhancer of zeste homolog 2 (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

  本公开涉及双功能化合物，其作为增强子锁定同源2的调节剂而发挥作用。具体而言，本公开涉及包含一端为Von Hippel-Lindau、cereblon、凋亡抑制蛋白或鼠双分子同源2配体的双功能化合物，该配体与相应的E3泛素连接酶结合，另一端含有结合目标蛋白的基团，使目标蛋白靠近泛素连接酶以实现目标蛋白的降解（和抑制）。本公开展示了与目标蛋白的降解/抑制相关的广泛药理活性范围。本公开的化合物和组合物用于治疗或预防由目标蛋白聚集或积累导致的疾病或紊乱。
• [EN] PROCESS OF SYNTHESIZING DIISOPROPYLAMINW-DISILANES<br/>[FR] PROCÉDÉ DE SYNTHÈSE DE DIISOPROPYLAMINO-DISILANES
  申请人：DOW CORNING

  公开号：WO2015184214A1

  公开（公告）日：2015-12-03

  Chemical processes comprise selectively synthesizing diisopropylamino-disilanes and reduction of chloride in aminosilanes, and the compositions comprise the diisopropylamino- disilanes and at least one reaction by-product prepared thereby. The diisopropylamino- disilanes are diisopropylamino-pentachlorodisilane and diisopropylamino-disilane.

  化学过程包括选择性合成二异丙胺基二硅烷和氨基硅烷中氯化物的还原，组合物包括二异丙胺基二硅烷和至少一种由此制备的反应副产物。二异丙胺基二硅烷是二异丙胺基五氯二硅烷和二异丙胺基二硅烷。

表征谱图