六胜肽-10 | 146439-94-3

• 物质功能分类: 生物化工 - 多肽
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 六胜肽-10
• 英文名称: Hexapeptide-10
• 英文别名: (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S,3S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-methylpentanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-3-methylbutanoic acid
• CAS: 146439-94-3
• 化学式: C₂₈H₅₃N₇O₈
• 分子量: 615.8
• InChiKey: OFGVZFQUFJYSGS-CPDXTSBQSA-N

物化性质

• 沸点：
  1012.5±65.0 °C(Predicted)
• 密度：
  1.176±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  43
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  255
• 氢给体数：
  9
• 氢受体数：
  10

安全信息

• 危险性防范说明：
  P280,P305+P351+P338
• 危险性描述：
  H302

文献信息

• Functional MRI agents for cancer imaging
  申请人：——

  公开号：US20040146463A1

  公开（公告）日：2004-07-29

  The invention relates to novel magnetic resonance imaging contrast agents for imaging cancer.

  本发明涉及用于癌症成像的新型磁共振成像对比剂。
• SYNTHETIC DIBLOCK COPOLYPEPTIDE HYDROGELS FOR USE IN THE CENTRAL NERVOUS SYSTEM
  申请人：Deming Timothy J.

  公开号：US20120093722A1

  公开（公告）日：2012-04-19

  This invention relates, e.g., to a composition suitable for administration to the central nervous system (CNS), comprising a block copolypeptide hydrogel, which comprises a biologically active material that is mixed with the hydrogel or that is attached to the polypeptide chain of the hydrogel, wherein the composition is suitable for administration to the CNS. Also disclosed are methods of making and using compositions of the invention as depots or as scaffolds for cell migration, and pharmaceutical compositions and kits for implementing methods of the invention.

  本发明涉及一种适合于给中枢神经系统（CNS）施用的组合物，包括一种块状共聚肽水凝胶，其中包括与水凝胶混合或附着于水凝胶的多肽链上的生物活性物质，该组合物适合于给CNS施用。本发明还公开了制备和使用本发明组合物作为沉积物或细胞迁移支架的方法，以及用于实施本发明方法的制药组合物和工具包。
• Latent reactive polymers with biologically active moieties
  申请人：SurModics, Inc.

  公开号：EP1577670A2

  公开（公告）日：2005-09-21

  The present invention relates to a polybifunctional reagent having a polymeric backbone, one or more pendent photoreactive moieties, and two or more pendent bioactive groups. The reagent can be activated to form a bulk material or can be brought into contact with the surface of a previously formed biomaterial and activated to form a coating. The pendent bioactive groups function by promoting the attachment of specific molecules or cells to the bulk material or coated surface. Bioactive groups can include proteins, peptides, carbohydrates, nucleic acids and other molecules that are capable of binding noncovalently to specific and complimentary portions of molecules or cells.

  本发明涉及一种具有聚合物骨架、一个或多个下垂光活性分子和两个或多个下垂生物活性基团的多官能团试剂。该试剂可以活化形成块状材料，也可以与先前形成的生物材料表面接触并活化形成涂层。悬垂生物活性基团通过促进特定分子或细胞附着到主体材料或涂层表面来发挥作用。生物活性基团可包括蛋白质、肽、碳水化合物、核酸和其他能够与分子或细胞的特定和互补部分非共价结合的分子。
• Novel functional agents for magnetic resonance imaging
  申请人：——

  公开号：US20030021750A1

  公开（公告）日：2003-01-30

  The present invention is directed to non-macrocyclic functional MRI contrast agents that can be used to detect the presence of physiological target substances.

  本发明涉及可用于检测生理目标物质存在的非大环功能性磁共振成像造影剂。
• Multifunctional photodynamic agents for treating of disease
  申请人：MPA Technologies, Inc.

  公开号：US20040247527A1

  公开（公告）日：2004-12-09

  The present invention is directed to methods and compositions comprising multifunctional (usually bi- or tri-functional) agents that incorporate a targeting moiety, a photo dynamic therapy (PDT) moiety (either one or two photon), and an optional imaging agent (such as a chromophore, contrast agent, etc.).

  本发明涉及包含多功能（通常是双功能或三功能）制剂的方法和组合物，这些制剂包含靶向分子、光动力疗法（PDT）分子（单光子或双光子）和任选成像剂（如发色团、造影剂等）。