4′-hydroxy-3′,5′-dimethoxyphenylpropanol-1-O-β-D-xylopyranosyl(1→6)-O-β-D-glucopyranoside

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4′-hydroxy-3′,5′-dimethoxyphenylpropanol-1-O-β-D-xylopyranosyl(1→6)-O-β-D-glucopyranoside
• 英文别名: lyciumoside C
• 化学式: C₂₂H₃₄O₁₃
• 分子量: 506.504
• InChiKey: WXJKMBZVQRDCMZ-PMTNWZTMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.38
• 重原子数：
  35.0
• 可旋转键数：
  10.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  196.99
• 氢给体数：
  7.0
• 氢受体数：
  13.0

反应信息

• 作为反应物：
  描述：

  4′-hydroxy-3′,5′-dimethoxyphenylpropanol-1-O-β-D-xylopyranosyl(1→6)-O-β-D-glucopyranoside 在 盐酸 、 吡啶 、 L-半胱氨酸甲酯盐酸盐 、 三甲基硅咪唑 作用下， 以 水 为溶剂， 反应 6.0h， 生成 可得然胶 、 beta-D-吡喃木糖
  参考文献：
  名称：

  Antihyperlipidemic glycosides from the root bark of Lycium chinense

  摘要：

  Three new glycosides (1-3), together with six known ones (4-9), were isolated from the root bark of Lycium chinense. Their structures were elucidated on the basis of MS and NMR spectroscopic data. Five compounds (3, 5, 6, 8, and 9) exhibited potent antihyperlipidemic activities in HepG2 cells as assessed by Oil Red O staining and significant inhibition of intracellular triglyceride (TG) levels, whereas two compounds (5 and 9) significantly reduced total cholesterol (TC) levels.[GRAPHICS].

  DOI：

  10.1080/14786419.2018.1466125

文献信息

• Antihyperlipidemic glycosides from the root bark of <i>Lycium chinense</i>
  作者：Hui Chen、Yu-Jie Li、Yan-Jun Sun、Xiao-Kun Li、Gong Jian-Hong、Ya Wu、Fang-Yi Su、Kun Du、Yan-Li Zhang、Wei-Sheng Feng

  DOI：10.1080/14786419.2018.1466125

  日期：2019.9.17

  Three new glycosides (1-3), together with six known ones (4-9), were isolated from the root bark of Lycium chinense. Their structures were elucidated on the basis of MS and NMR spectroscopic data. Five compounds (3, 5, 6, 8, and 9) exhibited potent antihyperlipidemic activities in HepG2 cells as assessed by Oil Red O staining and significant inhibition of intracellular triglyceride (TG) levels, whereas two compounds (5 and 9) significantly reduced total cholesterol (TC) levels.[GRAPHICS].