1,3-bis(2-(4,5-diphenyl-1H-imidazol-2-yl)phenoxy)propane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1,3-bis(2-(4,5-diphenyl-1H-imidazol-2-yl)phenoxy)propane
• 英文别名: 2-[2-[3-[2-(4,5-diphenyl-1H-imidazol-2-yl)phenoxy]propoxy]phenyl]-4,5-diphenyl-1H-imidazole
• 化学式: C₄₅H₃₆N₄O₂
• 分子量: 664.806
• InChiKey: NDWLDGRUYJKJTJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.2
• 重原子数：
  51
• 可旋转键数：
  12
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  75.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  水杨醛 在 ammonium acetate 、 碘 、 potassium carbonate 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 生成 1,3-bis(2-(4,5-diphenyl-1H-imidazol-2-yl)phenoxy)propane
  参考文献：
  名称：

  One-pot synthesis of bis(4,5-diphenylimidazol-2-yl-phenyl)glycols and evaluation of their antimicrobial activity

  摘要：

  A new series of bis(4,5-diphenylimidazol-2-yl-phenyl)glycols were synthesized by reaction of bis(formylphenyl)glycols with benzil/benzoin and ammonium acetate in presence of iodine/acetic acid in ethanol. All newly synthesized compounds were characterised by IR, H-1, C-13 NMR, and MS data and tested for antimicrobial and antifungal activity.

  DOI：

  10.1134/s107036321503024x

文献信息

• ZnO nanoparticles catalyzed synthesis of <i>bis</i>- and poly(imidazoles) as potential anticancer agents
  作者：Ali M. S. Hebishy、Mohamed Saleh Abdelfattah、Abdullah Elmorsy、Ahmed H. M. Elwahy

  DOI：10.1080/00397911.2020.1726396

  日期：2020.4.2

  Abstract A synthesis of bis- and poly(imidazoles) by one-pot three-component reaction of 1,2-diketone with aldehydes and ammonium acetate in the presence of catalytic amount of ZnO nanocatalyst is reported. The reactions were performed under conventional heating as well as under microwave irradiation. The anticancer activities of the synthesized compounds were evaluated against human breast adenocarcinoma

  摘要 报道了在催化量的 ZnO 纳米催化剂存在下，通过 1,2-二酮与醛和乙酸铵的一锅三组分反应合成双和聚（咪唑）。反应在常规加热以及微波辐射下进行。合成化合物对人乳腺癌细胞系 (MCF-7)、肝癌细胞系 (HepG-2) 和上皮结肠直肠腺癌细胞 (CaCO-2) 的抗癌活性进行了评估。细胞毒活性的结果表明，含有 4,5-二呋喃环的双（咪唑）类似物的化合物 16b 对 HepG-2 癌细胞有效（IC50 = 8.14 µM），具有高选择性指数（SI = 27.47）。包含四个咪唑单元的化合物 25 对 MCF-7 细胞系具有活性 (IC50 = 12. 62 µM) 并显示出显着的选择性指数 (SI = 7.71)。此外，含有六个咪唑单元的化合物 27 对 CaCO-2 细胞系表现出最高的活性（IC50 = 32.51 μM），SI = 4.09。图形概要
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