9-amino-2,3-dihydrothieno[3,2-b]quinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9-amino-2,3-dihydrothieno[3,2-b]quinoline
• 英文别名: 2,3-dihydrothieno[3,2-b]quinoline-9-amine；9-amino-1-thia-2,3-dihydro-1H-cyclopenta[b]quinoline；2,3-Dihydrothieno[3,2-b]quinolin-9-amine
• 化学式: C₁₁H₁₀N₂S
• 分子量: 202.28
• InChiKey: KFMKBECNQXAAIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  64.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氨基苯甲腈 生成 9-amino-2,3-dihydrothieno[3,2-b]quinoline
  参考文献：
  名称：

  SHUTSKE, GREGORY M.;EFFLAND, RICHARD C.

  摘要：

  DOI：

文献信息

• Certain 9-amino-2-(or 4)-oxa 1,2,3,4-tetrahydro- or
  申请人：Pfizer Inc.

  公开号：US05202440A1

  公开（公告）日：1993-04-13

  Compounds selected from the group consisting of 9-amino-4-oxa-1,2,3,4-tetrahydro-acridine, 9-amino-2-oxa-1,2,3,4-tetrahydro-acridine, 9-amino-8-fluoro-4-oxa-1,2,3,4-tetrahydro-acridine, 9-amino-4-oxa-1,2,3,4,5,6,7,8-octahydro-acridine or a pharmaceutical acceptable salt thereof are useful treating Alzheimer's disease.

  从由9-氨基-4-氧杂-1,2,3,4-四氢吖啶、9-氨基-2-氧杂-1,2,3,4-四氢吖啶、9-氨基-8-氟-4-氧杂-1,2,3,4-四氢吖啶、9-氨基-4-氧杂-1,2,3,4,5,6,7,8-八氢吖啶或其药物可接受盐组成的组中选出的化合物，用于治疗阿尔茨海默病是有用的。
• Quinoline derivatives
  申请人：SUMITOMO PHARMACEUTICALS COMPANY, LIMITED

  公开号：EP0268871A1

  公开（公告）日：1988-06-01

  Quinoline derivatives of the formula, wherein R1, R2, R3 and R4 are each hydrogen or one of a specific range of substituents, is one of a specific range of cyclic groups, and are useful as pharmaceuticals such as anti-senile dementia. They may be prepared by synthetic routes analogous to those described in the literature for preparing known compounds.

  喹啉衍生物的公式，其中R1、R2、R3和R4各自是氢或特定范围内的一个取代基，是一个特定范围内的环状基团，并且可用作抗老年痴呆症等药物。它们可以通过与文献中描述的已知化合物相似的合成路线来制备。
• Agents and crystals for improving excretory potency of urinary bladder
  申请人：——

  公开号：US20020177593A1

  公开（公告）日：2002-11-28

  Agents for improving potentcy of the urinary bladder which comprises an amine compound of non-carbamate-type having an acetylcholinesterase-inhibiting action. Particularly, crystals of a tricyclic, condensed, heterocyclic derivative are provided, which possess an excellent action to inhibit acetylcholine esterase and an action to improve the excretory potency of urinary bladder. As an example, crystals of of 8-[3-[1-[(3-fluorophenyl)-methyl]-4-piperidinyl]-1-oxopropyl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one or a salt thereof and pharmaceutical compositions containing them are disclosed.

  改善膀胱功能的药剂，包括一种非卡巴酯类胺化合物，具有乙酰胆碱酯酶抑制作用。特别地，提供了一种三环、紧凑、杂环衍生物的晶体，具有优异的抑制乙酰胆碱酯酶作用和改善膀胱排泄功能的作用。例如，揭示了8-[3-[1-[(3-氟苯基)-甲基]-4-哌啶基]-1-氧代丙基]-1,2,5,6-四氢-4H-吡咯烷[3,2,1-ij]-喹啉-4-酮或其盐和含有它们的药物组合物。
• Fused heteroalkylene quinolinamines
  申请人：Hoechst-Roussel Pharmaceuticals Incorporated

  公开号：US05206387A1

  公开（公告）日：1993-04-27

  There are disclosed compounds having the formula ##STR1## wherein n is 1-4; R is hydrogen, loweralkyl or loweralkylcarbonyl; R.sub.1 is hydrogen, loweralkyl, loweralkylcarbonyl, aryl, diloweralkylaminoloweralkyl, arylloweralkyl, diarylloweralkyl, oxygen-bridged arylloweralkyl, or oxygen-bridged diaryllowerallyl; A is a direct bond of (CHR.sub.3).sub.m, m being 1-3; X is hydrogen, loweralkyl, cycloalkyl, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, formyl, loweralkylcarbonyl, arylcarbonyl, --SH, loweralkylthio, --NHCOR.sub.4 or --NR.sub.5 R.sub.6, R.sub.4 being hydrogen or loweralkyl, and R.sub.5 and R.sub.6 being independently hydrogen, loweralkyl or cycloalkyl; Y is O, S or NR.sub.7 ; and each R.sub.2, each R.sub.3 and R.sub.7 are independently hydrogen or loweralkyl, or taken two at a time form a methylene or ethylene group constituting a part of a ring of at least five atoms; stereo, optical and geometrical isomers thereof, and pharmaceutically acceptable acid addition salts thereof, which are useful for enhancing memory.

  公开了具有以下式子的化合物：##STR1## 其中n为1-4；R为氢，低碳基或低碳基羰基；R.sub.1为氢，低碳基，低碳基羰基，芳基，二低碳基氨基低碳基，芳基低碳基，二芳基低碳基，氧桥芳基低碳基或氧桥二芳基低烯基；A为(CHR.sub.3).sub.m的直接键，其中m为1-3；X为氢，低碳基，环烷基，低碳氧基，卤素，羟基，硝基，三氟甲基，甲酰基，低碳基羰基，芳基羰基，--SH，低碳基硫基，--NHCOR.sub.4或--NR.sub.5R.sub.6，其中R.sub.4为氢或低碳基，R.sub.5和R.sub.6独立地为氢，低碳基或环烷基；Y为O，S或NR.sub.7；每个R.sub.2，每个R.sub.3和R.sub.7独立地为氢或低碳基，或者两个取自其中一个甲基或乙烯基团，构成至少五个原子的环的一部分；它们的立体、光学和几何异构体以及药学上可接受的酸盐，对于增强记忆有用。
• Agents for improving excretory potency of urinary bladder
  申请人：——

  公开号：US20040116457A1

  公开（公告）日：2004-06-17

  Agents for improving excretory potency of the urinary bladder which comprises an amine compound of non-carbamate-type having an acetylcholinesterase-inhibiting action.

  改善排泄能力的尿道代理，包括一种非卡巴酯型胺类化合物，具有乙酰胆碱酯酶抑制作用。