acridine benzoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: acridine benzoic acid
• 英文别名: Acridin-10-ium;benzoate
• 化学式: C₇H₆O₂*C₁₃H₉N
• 分子量: 301.345
• InChiKey: RBNWNQBUMOMDLR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.86
• 重原子数：
  23
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  吖啶 、 苯甲酸 以 乙醇 、 水 为溶剂， 反应 0.25h， 生成 acridine benzoic acid
  参考文献：
  名称：

  卤素取代基对由a啶和苯甲酸形成的共晶体中卤素和氢键形成的影响†

  摘要：

  为了确定苯甲酸苯环中的邻位和间位卤素取代基对在晶体包装中卤素（X）为A的晶体中C–H⋯X氢键和X⋯O卤素键的形成的影响氟，氯，溴或碘原子，我们合成并结构表征了由a啶和苯甲酸形成的九个共晶体：:啶·苯甲酸（1），a啶·2-氟苯甲酸（2），a啶·2-氯苯甲酸（3），cr啶·2-溴苯甲酸（4），cr啶·2-碘苯甲酸（5），cr啶·3-氟苯甲酸（6），cr啶·3-氯苯甲酸（7）），a啶·3-溴苯甲酸（8）和a啶·3-碘苯甲酸（9）。比较了氢和卤素键的数量，类型和强度，以及共晶1–9的熔点。对标题化合物共晶体中发生的分子间相互作用的系统分析表明，卤素键与氢键之间的竞争取决于卤素取代基的位置和类型。

  DOI：

  10.1039/c5ce01321f

文献信息

• Luminescence detection device
  申请人：MILES LABORATORIES, INC.

  公开号：EP0071859A2

  公开（公告）日：1983-02-16

  Disclosed is a luminescence detection device for quantitatively detecting an analyte in a liquid sample, which device comprises (1) a reaction compartment having, along a primary axis, opposite end portions, a first of which is for introduction of fluid reagents and sample into the compartment and the other of which forms a light transmissive aperture of predetermined size, the compartment being suitable to hold a composition which luminesces in response to contact with analyte-containing sample; (2) closure means in said first end portion for admitting a cannula, whereby fluid is introduced into said compartment, and for closing the reaction compartment; (3) a photoresponsive imaging layer; (4) means for associating the photoresponsive imaging layer and the reaction compartment such that the photoresponsive imaging layer is positioned, preferably substantially perpendicular to the primary axis of the reaction compartment, at a predetermined distance from the end portion forming the aperture so as to be exposed to light emanating therefrom; and (5) means for preventing exposure of the photoresponsive imaging layer to ambient light.

  本发明公开了一种用于定量检测液体样品中分析物的发光检测装置，该装置包括：(1) 沿主轴具有相对端部的反应室，其中第一个端部用于将流体试剂和样品引入反应室，另一个端部形成预定尺寸的透光孔，反应室适于容纳在与含分析物的样品接触时发光的组合物；(2) 位于所述第一端部分的关闭装置，用于容纳插管，从而将液体引入所述隔室，并关闭反应隔室； (3) 光致发光成像层；(4) 用于连接光致发光成像层和反应室的装置，使光致发光成像层的位置（最好与反应室的主轴基本垂直）与形成孔洞的端部保持预定距离，以便暴露于从那里发出的光；以及 (5) 用于防止光致发光成像层暴露于环境光的装置。
• Specific binding assay
  申请人：Bayer Corporation

  公开号：EP0140521A2

  公开（公告）日：1985-05-08

  @ A specific binding assay composition for determining a ligand in a sample, comprises (a) a binding partner for the ligand; (b) a detection system which has at least two components; (c) a selectively accessible vesicle having a surface-incorporated ligand or ligand analog and a first component of the detection system therein; (d) a substance which modifies vesicle accessibility in response to binding of surface-associated ligand or ligand analog and binding partner; and (e) at least one additional component of the detection system which is reactive with the first component to produce a detectable response which is reduced by association of the binding partner and vescile modifying substance with the variably accessible vesicle. A decrease in signal is measured upon reaction as compared to the signal of unreacted vesicles.

  一种用于确定样品中配体的特异性结合检测组合物，包括：(a) 配体的结合配体；(b) 检测系统，该检测系统至少有两个组分；(c) 选择性可进入的囊泡，囊泡中有表面结合的配体或配体类似物和检测系统的第一个组分；(e) 检测系统的至少另外一种成分，它与第一种成分反应产生可检测的反应，该反应因结合配体和囊泡修饰物质与可变囊泡的结合而减弱。与未反应的囊泡的信号相比，反应后的信号降低。
• Novel assay product and process
  申请人：POLAROID CORPORATION

  公开号：EP0173375A1

  公开（公告）日：1986-03-05

  @ An assay device for determining the presence of analyte (e.g. antigens and/or haptens) in a liquid sample comprising a first (reagent) zone containing reference antigens and labeled Fab fragments which are capable of reacting immunologically with said analyte and said reference antigens, said Fab fragments being positioned in said first zone such that they will be removed therefrom when reacted with analyte passing through said first zone but will not be removed from said first zone in the absence of analyte; and a second (reaction) zone wherein the reaction product of said labeled Fab fragment-analyte passes after removal from said first zone and in which said label or a reaction product thereof emits a detectable signal. The detectable signal emitted in said second zone may, for example, be a color produced by reaction with a chromogenic material in said second zone or it may, for example, be electromagnetic radiation, e. g. chemiluminescence or fluorescence produced by interaction with a reagent in said second zone.

  一种用于确定液体样品中是否存在分析物（如抗原和/或抗原）的检测装置。第一（试剂）区包含参考抗原和可与所述分析物和所述参考抗原发生免疫反应的标记 Fab 片段，所述 Fab 片段位于所述第一区，当与通过所述第一区的分析物发生反应时，它们会从第一区移除，但在没有分析物的情况下，它们不会从第一区移除；第二（反应）区，所述标记 Fab 片段与分析物的反应产物从所述第一区移除后通过该区，所述标记或其反应产物在该区发出可检测信号。例如，在所述第二区发出的可检测信号可以是与所述第二区的发色材料反应产生的颜色，也可以是与所述第二区的试剂相互作用产生的电磁辐射，如化学发光或荧光。
• US4396579A
  申请人：——

  公开号：US4396579A

  公开（公告）日：1983-08-02
• US4713324A
  申请人：——

  公开号：US4713324A

  公开（公告）日：1987-12-15