4-methoxy-2,2-dimethyl-pentan-3-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-methoxy-2,2-dimethyl-pentan-3-one
• 英文别名: 4-Methoxy-2,2-dimethyl-pentan-3-on；4-Methoxy-2,2-dimethylpentan-3-one
• 化学式: C₈H₁₆O₂
• 分子量: 144.214
• InChiKey: WWEKVTZLEGICNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-甲氧基丙腈 、 magnesium,2-methylpropane,bromide 在 乙醚 作用下， 生成 4-methoxy-2,2-dimethyl-pentan-3-one
  参考文献：
  名称：

  Keto Ethers. X. 1-Methoxyethyl Alkyl Ketones

  摘要：

  DOI：

  10.1021/ja01264a046

文献信息

• Oxidation of Alkynes by Hydrogen Peroxide Catalyzed by Methylrhenium Trioxide
  作者：Zuolin Zhu、James H. Espenson

  DOI：10.1021/jo00129a010

  日期：1995.12

  The oxidation of alkynes with hydrogen peroxide is catalyzed by methylrhenium trioxide. The reactions can be rationalized by postulating that an oxirene intermediate is formed between a rhenium peroxide and the alkyne. Internal alkynes yield alpha-diketones and carboxylic acids, the latter from the complete cleavage of the triple bonds. Rearrangement products were observed only for aliphatic alkynes. Terminal alkynes gave carboxylic acids and their derivatives and alpha-keto acids as the major products, but their yields varied with the solvent used.
• Conjugates useful in the treatment of prostate cancer
  申请人：Brady F. Stephen

  公开号：US20070021350A1

  公开（公告）日：2007-01-25

  Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are disclosed. The conjugates of the invention are characterized by attachment of the cleavable oligopeptide to the oxygen atom at the 4-position on a vinca drug that has be desacetylated. Such conjugates are useful in the treatment of prostatic cancer and benign prostatic hypertrophy (BPH).
• ADHESIVE COMPOSITIONS AND METHODS
  申请人：Novomer, Inc.

  公开号：US20150083326A1

  公开（公告）日：2015-03-26

  The present invention encompasses polyurethane adhesive compositions comprising aliphatic polycarbonate chains. In one aspect, the present invention encompasses polyurethane adhesives derived from aliphatic polycarbonate polyols and polyisocyanates wherein the polyol chains contain a primary repeating unit having a structure. In another aspect, the invention provides articles comprising the inventive polyurethane compositions as well as methods of making such compositions.
• TREPROSTINIL DERIVATIVES AND COMPOSITIONS AND USES THEREOF
  申请人：CORSAIR PHARMA, INC.

  公开号：US20160368854A1

  公开（公告）日：2016-12-22

  The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
• US9394227B1
  申请人：——

  公开号：US9394227B1

  公开（公告）日：2016-07-19