1-methyl-3-(1-octadecyl-nonadecyl)-3H-imidazol-1-ium chloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-methyl-3-(1-octadecyl-nonadecyl)-3H-imidazol-1-ium chloride
• 英文别名: MONI；1-Heptatriacontan-19-yl-3-methylimidazol-3-ium;chloride
• 化学式: C₄₁H₈₁N₂*Cl
• 分子量: 637.561
• InChiKey: SJEKYQHPWDSTEO-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  11.16
• 重原子数：
  44
• 可旋转键数：
  35
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  8.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-甲基咪唑 、 Heptatriacontan-19-yl methanesulfonate 在 盐酸 作用下， 以 甲醇 、 水 为溶剂， 反应 162.0h， 以85%的产率得到1-methyl-3-(1-octadecyl-nonadecyl)-3H-imidazol-1-ium chloride
  参考文献：
  名称：

  Compositions for transfection of oligonucleotides active for gene silencing and their biological and therapeutical applications

  摘要：

  该发明涉及包含用于RNA干扰的寡核苷酸活性和具有以下结构的两性阳离子分子的转染组合物：其中- X为N-R1、S或O，其中R1是C1-C4烷基基团或羟基化的C3-C6烷基基团，- R2和R3，相同或不同，代表H或C1-C4烷基基团，或者R2和R3连接在一起形成具有6个元素的环或杂环，- E是C1-C5烷基间隔，- R4和R5，相同或不同，代表饱和或不饱和的线性或支链的C10-C36烃基或氟烃基链，可选地包括C3-C6环烷基，- A-是生物相容性阴离子。将该组合物用作药物。

  公开号：

  EP1844772A1

文献信息

• COMPOSITIONS FOR TRANSFECTING MRNA INTO A CELL AND THEIR APPLICATIONS
  申请人：PolyPlus Transfection

  公开号：EP3646854A1

  公开（公告）日：2020-05-06

  The present invention relates to compositions for transfecting a messenger RNA (mRNA) into a cell and their applications. The present invention is directed to a composition for transfecting a mRNA into a cell comprising a mRNA, at least one neutral lipid and a cationic lipid of formula (I), wherein R1 R2, R3, R4 and R5, (CH2)n and A- are as defined in the description. The present invention also relates to uses of said composition and to a method for in vitro transfection of live cells.

  本发明涉及将信使 RNA（mRNA）转染到细胞中的组合物及其应用。本发明涉及一种用于将 mRNA 转染到细胞中的组合物，该组合物包含 mRNA、至少一种中性脂质和式 (I) 的阳离子脂质，其中 R1 R2、R3、R4 和 R5、(CH2)n 和 A- 如说明中所定义。本发明还涉及所述组合物的用途和活细胞体外转染的方法。
• COMPOSITIONS FOR TRANSFECTION OF OLIGONUCLEOTIDES ACTIVE FOR GENE SILENCING AND THEIR BIOLOGICAL AND THERAPEUTICAL APPLICATIONS
  申请人：Polyplus-Transfection SA

  公开号：EP2004156A2

  公开（公告）日：2008-12-24
• COMPOSITIONS FOR TRANSFECTING mRNA INTO A CELL AND THEIR APPLICATIONS
  申请人：POLYPLUS TRANSFECTION

  公开号：US20210386841A1

  公开（公告）日：2021-12-16

  Disclosed are compositions for transfecting a messenger RNA (mRNA) into a cell and their applications. The present invention is directed to a composition for transfecting a mRNA into a cell including a mRNA, at least one neutral lipid and a cationic lipid of formula (I), wherein R 1 R 2 , R 3 , R 4 and R 5 , (CH 2 ) n and A − are as defined in the description. Also disclosed are uses of the composition and to a method for in vitro transfection of live cells.
• US8399422B2
  申请人：——

  公开号：US8399422B2

  公开（公告）日：2013-03-19
• [EN] COMPOSITIONS FOR TRANSFECTION OF OLIGONUCLEOTIDES ACTIVE FOR GENE SILENCING AND THEIR BIOLOGICAL AND THERAPEUTICAL APPLICATIONS<br/>[FR] COMPOSITIONS DE TRANSFECTION D'OLIGONUCLÉOTIDES ACTIFS DANS LE BLOCAGE DES GÈNES, ET APPLICATIONS BIOLOGIQUES ET THÉRAPEUTIQUES DE CELLES-CI
  申请人：POLYPLUS TRANSFECTION SA

  公开号：WO2008004058A2

  公开（公告）日：2008-01-10

  [EN] The invention relates to compositions of transfection comprising an oligonucleotide and an amphiphilic cationic molecule of formula (I) wherein, - X is N-R₁, S or O, R₁ being a C1-C4 alkyl radical or an hydroxylated C3- C6 alkyl radical, R₂ and R₃, identical or different, represent H or a C1-C4 alkyl radical, or R₂ and R₃ are linked together to form a saturated or unsaturated cycle or a heterocycle having 5 or 6 elements, E is a C1-C5 alkyl spacer, R₄ and R₅, identical or different, represent saturated or unsaturated, linear or branched, C10-C36 hydrocarbon or fluorocarbon chains, optionally comprising C3-C6 cycloalkyle, A- is a biocompatible anion. The invention relates to compositions active for oligonucleotides delivery into eukaryotic cells in culture, ex vivo or in vivo. The invention relates to compositions of transfection comprising an oligonucleotide active for RNA interference. Such compositions can be used as tools for biological studies or as drugs for therapies.
  [FR] La présente invention concerne des compositions de transfection comprenant un oligonucléotide et une molécule cationique amphiphile de formule (I), dans laquelle - X est N-R₁, S ou O, R₁ étant un radical alkyle C1-C4 ou un radical alkyle C3- C6 hydroxylé, R₂ et R₃, identiques ou différents, représentent H ou un radical alkyle C1-C4, ou R₂ et R₃ sont liés ensemble pour former un cycle saturé ou insaturé ou un hétérocycle présentant 5 ou 6 éléments, E est un espaceur alkyle C1-C5, R₄ et R₅, identiques ou différents, représentent des chaînes fluorocarbonées ou d'hydrocarbure C10-C36 saturées ou insaturées, linéaires ou ramifiées, comprenant éventuellement un cycloalkyle C3-C6, et A- est un anion biocompatible. L'invention concerne également des compositions actives pour l'apport d'oligonucléotides dans des cellules eucaryotes en culture, ex vivo ou in vivo. L'invention concerne en outre des compositions de transfection comprenant un oligonucléotide actif pour interférence ARN. De telles compositions peuvent être utilisées en tant qu'outils dans des études biologiques ou en tant que médicaments dans des thérapies.