千层纸素A-7-0-&Beta-D-葡萄糖醛酸苷 | 256925-92-5

• 物质功能分类: 天然产物 - 萜类
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 千层纸素A-7-0-&Beta-D-葡萄糖醛酸苷
• 中文别名: 升麻酮醇3-O-alpha-L-拉伯糖苷；千层纸素A-7-0-Β-D-葡萄糖醛酸苷；千层纸素A-7--Β-D-葡萄糖醛酸苷
• 英文名称: Cimiracemoside C
• 英文别名: (2S,3R,4S,5S)-2-[[(1S,2R,3S,4R,7R,9S,12R,14S,17R,18R,19R,21R,22S)-2-hydroxy-22-(2-hydroxypropan-2-yl)-3,8,8,17,19-pentamethyl-23,24-dioxaheptacyclo[19.2.1.01,18.03,17.04,14.07,12.012,14]tetracosan-9-yl]oxy]oxane-3,4,5-triol
• CAS: 256925-92-5
• 化学式: C₃₅H₅₆O₉
• 分子量: 620.8
• InChiKey: BTPYUWOBZFGKAI-BKJHYQRZSA-N

物化性质

• 熔点：
  258-260℃
• 沸点：
  740.3±60.0 °C(Predicted)
• 密度：
  1.32
• 溶解度：
  甲醇（微量）、吡啶（微量）

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  44
• 可旋转键数：
  3
• 环数：
  8.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  138
• 氢给体数：
  5
• 氢受体数：
  9

安全信息

• WGK Germany：
  3

制备方法与用途

生物活性方面，Cimiracemoside C 是升麻中的一种有效成分，能够激活 AMPK，显示出潜在的抗糖尿病作用。

文献信息

• NOVEL PHARMACOLOGICAL USE OF CIMICIFUGA EXTRACT
  申请人：Max Zeller Söhne AG

  公开号：EP2874637B1

  公开（公告）日：2019-08-14
• COMBINATION OF CIMICIFUGA AND PETASITES EXTRACTS FOR ANTICANCER THERAPY AND PROPHYLAXIS
  申请人：Max Zeller Söhne AG

  公开号：EP3906040A1

  公开（公告）日：2021-11-10
• Compositions and Methods Comprising Zingiber Species
  申请人：Li Dan

  公开号：US20080160116A1

  公开（公告）日：2008-07-03

  An aspect of the present invention relates to compositions comprising a gingerol, for example, compositions comprising gingerol in an amount greater than about 2% by weight. In some aspects of the invention, the composition comprises 6-gingerol, 8-gingerol, 10-gingerol, 6-shagaol, or combinations thereof. Another aspect of the invention relates to a method for extracting a ginger species comprising, sequentially extracting a ginger species plant material to yield an essential oil fraction, a gingerol fraction, a phenolic fraction, and a polysaccharide fraction, wherein the essential oil and gingerol fractions are derived by extracting plant feedstock material by supercritical carbon dioxide extraction, the phenolic fraction is extracted from the plant feedstock material or from the remainder of the essential oil and gingerol extractions by hydroalcoholic extraction, and the polysaccharide fraction is derived by water extraction of the remainder of the phenolic extraction.
• TRITERPENE GLYCOSIDE AND TRITERPENE COMPOSITIONS AND METHODS OF USING SAME
  申请人：Research Foundation of the City University of New York

  公开号：US20140199297A1

  公开（公告）日：2014-07-17

  In the present invention, different strategies are used to improve the bioavailability of triterpene glycosides and triterpenes including, for example, (a) a covalent approach involving modification with polyethylene glycol and (b) a formulation approach involving non-covalent encapsulation in antibody targeted pol(DL-lactic acid) nanoparticles.
• PHARMACOLOGICAL USE OF CIMICIFUGA EXTRACT
  申请人：Max Zeller Soehne AG

  公开号：US20150125555A1

  公开（公告）日：2015-05-07

  The present invention relates to the novel use of an extract from a Cimicifuga species, preferably Cimicifuga racemosa (also termed Actaea racemosa L; black cohosh). In particular, the invention is directed to an extract from Cimicifuga sp., preferably Cimicifuga racemosa , for use in the therapeutic or prophylactic treatment of diabetes, preferably diabetes mellitus type 2, the use of such extracts for preparing a medicament, corresponding pharmaceutical compositions comprising the extract as well as a method for the therapeutic or prophylactic treatment of diabetes, preferably by oral administration of the extract or pharmaceutical composition.