6-(6-formyl-3,4-dihydroquinolin-1(2H)-yl)hexanoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-(6-formyl-3,4-dihydroquinolin-1(2H)-yl)hexanoic acid
• 英文别名: 6-(6-formyl-3,4-dihydro-2H-quinolin-1-yl)hexanoic acid
• 化学式: C₁₆H₂₁NO₃
• 分子量: 275.348
• InChiKey: IECISFBWJYQALI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-(6-formyl-3,4-dihydroquinolin-1(2H)-yl)hexanoic acid 、 C₁₄H₁₃BF₄I₂N₂ 在 哌啶 作用下， 以 甲苯 为溶剂， 反应 2.0h， 以30%的产率得到C₃₀H₃₃BF₄IN₃O₂
  参考文献：
  名称：

  光氧合可抑制tau淀粉样蛋白的形成†

  摘要：

  Tau淀粉样蛋白的形成和沉积是阿尔茨海默氏病发作的原因。特别地，tau蛋白的播种活性通过其在人脑中的传播在tau病理学的传播中起重要作用。在这里，我们证明了催化光氧化作用显着抑制了tau种子的活性，从而在体外和培养的细胞中均抑制了淀粉样蛋白的形成。

  DOI：

  10.1039/c9cc01728c
• 作为产物：
  描述：

  6-溴己酸甲酯 在 甲醇 、 sodium carbonate 、 sodium iodide 、 potassium hydroxide 、 三氯氧磷 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 55.0h， 生成 6-(6-formyl-3,4-dihydroquinolin-1(2H)-yl)hexanoic acid
  参考文献：
  名称：

  BORON-DIPYRRIN COMPLEX AND PHARMACEUTICAL PRODUCT CONTAINING SAME

  摘要：

  公开号：

  EP3266765B1

文献信息

• Near-Infrared Photoactivatable Oxygenation Catalysts of Amyloid Peptide
  作者：Jizhi Ni、Atsuhiko Taniguchi、Shuta Ozawa、Yukiko Hori、Yoichiro Kuninobu、Takashi Saito、Takaomi C. Saido、Taisuke Tomita、Youhei Sohma、Motomu Kanai

  DOI：10.1016/j.chempr.2018.02.008

  日期：2018.4

  Toxic aggregation of amyloid peptide and protein is intimately related to a number of human diseases, including Alzheimer's disease (AD). Here, we developed biocompatible photooxygenation catalyst 9, which can selectively oxygenate and degrade the pathogenic aggregation of AD-related amyloid-β peptide (Aβ) under near-infrared (NIR) light irradiation. On the basis of the structure of a fluorescent Aβ

  淀粉样肽和蛋白质的有毒聚集与许多人类疾病（包括阿尔茨海默氏病（AD））密切相关。在这里，我们开发了生物相容性光氧合催化剂9，它可以在近红外（NIR）光照射下选择性地氧化和降解AD相关淀粉样β肽（Aβ）的致病性聚集。根据荧光Aβ探针CRANAD-2的结构，引入了溴原子以增加用于光氧合的单线态氧的产生。分别使用菊糖苷和全氟烷基硼酸酯部分作为电子给体和-受体组分，显着增强了光催化活性并降低了光毒性。聚集的Aβ被9光氧化NIR照射下在细胞存在下减弱了Aβ的细胞毒性。NIR的组织渗透性使小鼠皮肤下聚集的Aβ能够进行催化光氧化。此外，将催化剂与近红外光照射一起注射到AD模型小鼠的大脑中会导致大脑中完整Aβ水平的显着降低。
• Labeling of target molecules, identification of organelles and other applications, novel compositions, methods and kits
  申请人：Pande Praveen

  公开号：US20090226954A1

  公开（公告）日：2009-09-10

  The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins, nucleic acids and cellular organelles. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified to provide beneficial properties.

  本发明提供染料、反应染料和标记试剂，可用于检测或定量所需的目标分子，如蛋白质、核酸和细胞器。提供了可在溶液中自由使用的染料，其中染料与目标分子的结合提供信号产生。还提供了包含反应基团的染料，可用于将染料附着到将结合到所需目标分子的探针上。本发明的新型染料已被改性以提供有益的性质。
• Methods for detecting the presence, location or quantity of targets using novel dyes
  申请人：Xiang Yuejun

  公开号：US20100041020A1

  公开（公告）日：2010-02-18

  The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified by the addition of charged and polar groups to provide beneficial properties.

  本发明提供了染料、反应性染料和标记试剂，可用于检测或定量所需的目标分子，例如蛋白质和核酸。提供了可在溶液中自由使用的染料，其中染料与目标分子的结合提供信号生成。还提供了包含反应性基团的染料，可用于将染料连接到将结合到所需目标分子的探针上。本发明的新型染料已通过添加带电和极性基团进行改性，以提供有益的性质。
• Compositions useful for detection or quantification of desirable target molecules, novel dyes, composite dyes, and oligonucleotides or polynucleotides comprising such dyes
  申请人：Xiang Yuejun

  公开号：US20120040430A1

  公开（公告）日：2012-02-16

  The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified by the addition of charged and polar groups to provide beneficial properties.

  本发明提供了染料、反应性染料和标记试剂，可用于检测或定量所需的目标分子，例如蛋白质和核酸。提供了可在溶液中自由使用的染料，其中染料与目标分子的结合提供信号生成。还提供了包含反应性基团的染料，可用于将染料附着到将结合到所需目标分子的探针上。本发明的新型染料已通过添加带电和极性基团进行改性，以提供有益的性质。
• Dyes linked to target molecules, oligonucleotides or polynucleotides comprising dye molecules, composite dyes and other compositions useful for detecting or quantifying desirable target molecules
  申请人：Xiang Yuejun

  公开号：US20100228008A1

  公开（公告）日：2010-09-09

  The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified by the addition of charged and polar groups to provide beneficial properties.

  本发明提供了染料、反应染料和标记试剂，可用于检测或定量所需的目标分子，如蛋白质和核酸。提供了可在溶液中自由使用的染料，其中染料与目标分子的结合提供信号发生。还提供了包含反应基团的染料，可用于将染料附着到探针上，以结合所需的目标分子。本发明的新型染料经过修饰，添加了带电和极性基团，以提供有益的性质。