1-[4-(methylaminomethyl)phenyl]ethanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[4-(methylaminomethyl)phenyl]ethanone
• 英文别名: 4-acetyl-N-methylbenzylamine；1-(4-((Methylamino)methyl)phenyl)ethanone
• 化学式: C₁₀H₁₃NO
• 分子量: 163.219
• InChiKey: KAJUEISVGWXBTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-[4-(methylaminomethyl)phenyl]ethanone 在 dirhodium tetraacetate 、 三乙胺 作用下， 以 二氯甲烷 、 乙酸乙酯 为溶剂， 反应 12.0h， 生成 1,1'-(1,2-乙二基二-4,1-亚苯基)二-乙酮
  参考文献：
  名称：

  New route to substituted piperidines via the Stevens [1,2]-shift of ammonium ylides

  摘要：

  DOI：

  10.1021/ja00056a069

文献信息

• MODIFIED NUCLEOTIDE REAGENTS
  申请人：Pacific Biosciences of California, Inc.

  公开号：US20170321268A1

  公开（公告）日：2017-11-09

  Labeled nucleotide analogs comprising at least one avidin protein, at least one dye-labeled compound, and at least one nucleotide compound are provided. The analogs are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The analogs are detectable with high sensitivity at desirable wavelengths. They contain structural components that modulate the interactions of the analogs with DNA polymerase, thus decreasing photodamage and improving the kinetic and other properties of the analogs in sequencing reactions. Also provided are nucleotide and dye-labeled compounds of the subject analogs, as well as intermediates useful in the preparation of the compounds and analogs. Compositions comprising the compounds, methods of synthesis of the intermediates, compounds, and analogs, and mutant DNA polymerases are also provided.

  提供了包含至少一种亲和素蛋白、至少一种染料标记化合物和至少一种核苷酸化合物的标记核苷酸类似物。这些类似物在各种基于荧光的分析方法中很有用，包括在高密度下对大量高度多重光学反应进行分析，例如单分子实时核酸测序反应。这些类似物在理想波长下具有高灵敏度的可检测性。它们包含调节类似物与DNA聚合酶相互作用的结构组分，从而减少光损伤，并改善测序反应中类似物的动力学和其他性质。还提供了主题类似物的核苷酸和染料标记化合物，以及在制备这些化合物和类似物中有用的中间体。还提供了包含这些化合物的组合物、合成这些中间体、化合物和类似物的方法，以及突变的DNA聚合酶。
• [EN] TARGETED DELIVERY OF NICOTINAMIDE ADENINE DINUCLEOTIDE SALVAGE PATHWAY INHIBITORS<br/>[FR] ADMINISTRATION CIBLÉE D'INHIBITEURS DE LA VOIE DE RÉCUPÉRATION DE NICOTINAMIDE ADÉNINE DINUCLÉOTIDE
  申请人：SEATTLE GENETICS INC

  公开号：WO2018075600A1

  公开（公告）日：2018-04-26

  Compounds and compositions are disclosed in which a NAMPT Drug Unit is linked to a targeting Ligand Unit through a Unit from which a NAMPT inhibitor compound or derivative thereof is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as cancer or an autoimmune disease, using the compounds and compositions of the invention are also disclosed.

  本发明揭示了一种将NAMPT药物单元与靶向配体单元通过一个单元连接的化合物和组合物，其中NAMPT抑制剂化合物或其衍生物在靶向作用位点释放。本发明还揭示了利用这些化合物和组合物治疗由靶向异常细胞特征的疾病的方法，如癌症或自身免疫疾病。
• [EN] SUBSTITUTED 5-(HALOALKYL)-5-HYDROXY-ISOXAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI<br/>[FR] 5-(HALOALKYL)-5-HYDROXY-ISOXAZOLES SUBSTITUÉS POUR LUTTER CONTRE DES CHAMPIGNONS PHYTOPATHOGÈNES
  申请人：BASF SE

  公开号：WO2018202487A1

  公开（公告）日：2018-11-08

  The present invention relates to 5-(haloalkyl)-5-hydroxy-isoxazoles of the formula (I), or the N-oxides, or the agriculturally useful salts thereof, and the use thereof for controlling phytopathogenic fungi; to a method for combating phytopathogenic harmful fungi, which process comprises treating the fungi, the plants, the soil or seeds to be protected against fungal attack, with an effective amount of at least one compound of the formula (I), or an N-oxide, or an agriculturally acceptable salt thereof; and to agrochemical compositions comprising at least one compound of the formula (I), or an N-oxide, or an agriculturally acceptable salt thereof, and further comprising seeds.

  本发明涉及式(I)的5-(卤代烷基)-5-羟基异噁唑，或其N-氧化物，或其农业上有用的盐，以及其用于控制植物病原真菌的用途；用于对抗植物病原有害真菌的方法，该方法包括用式(I)的至少一种化合物，或其N-氧化物，或其农业上可接受的盐的有效量处理真菌、植物、土壤或需要保护免受真菌侵袭的种子；以及包含至少一种式(I)的化合物、或其N-氧化物，或其农业上可接受的盐的农药组合物，还包括种子。
• 一种银催化制备2-苯基-5-苯基-5-甲硫氰基-4,5-二氢噻唑类化合物的方法
  申请人：浙江农林大学暨阳学院

  公开号：CN111138378A

  公开（公告）日：2020-05-12

  本发明公开了一种银催化制备2‑苯基‑5‑苯基‑5‑甲硫氰基‑4,5‑二氢噻唑类化合物的方法，制备方法为：N‑甲基苯甲胺类化合物、苯甲硫酚类化合物和硫氰基乙酸类化合物在有机溶剂为介质，在催化剂及碳酸钠为碱的促进下充分反应，制得目标产物，反应物通过后处理制得2‑苯基‑5‑苯基‑5‑甲硫氰基‑4,5‑二氢噻唑类化合物；式中，R1选自下列之一：氢、卤素、甲基、异丙基、甲氧基；R2选自下列之一：氢、甲基、甲氧基；本发明方法产率良好，节约成本；对设备的要求较低，后处理方便；催化剂高效不需后处理，符合绿色环保要求；催化体系适应性广，适用于大规模工业化医药中间体生产。
• [EN] MODIFIED CYCLOPENTAPEPTIDES AND USES THEREOF<br/>[FR] CYCLOPENTAPEPTIDES MODIFIÉS ET LEURS UTILISATIONS
  申请人：TECH UNIVERSITÄT MÜNCHEN

  公开号：WO2015185162A1

  公开（公告）日：2015-12-10

  The present invention, among others, relates to a compound having a structure according to formula (I) or a pharmaceutically acceptable salt thereof, wherein Xaa1 are the iodo- substituted or methyl-substituted amino acids D- and L-Tyr, iodo-substituted or methyl- substituted D- and L- homotyrosine, iodo-substituted or methyl-substituted D- and L-Phe, iodo-substituted or methyl-substituted D- and L- p-OH-phenylglycine, and iodo-substituted or methyl-substituted D- or L- Trp, Xaa2 to Xaa4 are independently of each other, an optionally N-alkylated natural or unnatural amino acid, R is H or methyl, L is a linker moiety, Ar is a spacer comprising an aromatic moiety, and D comprises, preferably is i) a combination of an organic complexation agent and a radioactive or a detectable label; or ii) a radioactive or a detectable label, an organic complexation agent or an active substance, said active substance particularly being selected from cytotoxic agents, lipids, sugars, sugar conjugates, sugar derivatives, proteins and combinations thereof.

  本发明涉及一种具有以下式（I）结构或其药学上可接受的盐的化合物，其中Xaa1是碘代或甲基代氨基酸D-和L-Tyr，碘代或甲基代D-和L-同型酪氨酸，碘代或甲基代D-和L-Phe，碘代或甲基代D-和L-p-OH-苯基甘氨酸，以及碘代或甲基代D-或L-Trp，Xaa2至Xaa4是可选的N-烷基化的天然或非天然氨基酸，R为H或甲基，L为连接基团，Ar为含有芳香基团的间隔基团，D包括，优选为i）有机络合剂和放射性或可检测标记的组合；或ii）放射性或可检测标记，有机络合剂或活性物质，其中所述活性物质特别选自细胞毒性剂、脂质、糖、糖结合物、糖衍生物、蛋白质及其组合物。