4-(2,3-dimethoxyphenyl)-7,7-dimethyl-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-(2,3-dimethoxyphenyl)-7,7-dimethyl-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-dione
• 英文别名: SJ000065270-1；4-(2,3-dimethoxyphenyl)-7,7-dimethyl-3,4,6,8-tetrahydro-1H-quinoline-2,5-dione
• 化学式: C₁₉H₂₃NO₄
• 分子量: 329.396
• InChiKey: ZOGBVAJWJPJSOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  丙二酸环(亚)异丙酯 、 5,5-二甲基-1,3-环己二酮 、 2,3-二甲氧基苯甲醛 在 ammonium acetate 作用下， 反应 0.42h， 以84%的产率得到4-(2,3-dimethoxyphenyl)-7,7-dimethyl-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-dione
  参考文献：
  名称：

  One-Pot Synthesis of 1,4-Dihydropyridine Derivatives Catalyzed by Silica-Coated Magnetic NiFe2O4 Nanoparticles-Supported H14[NaP5W30O110]

  摘要：

  Silica-coated magnetic NiFe2O4 nanoparticles-supported H-14[NaP5W30O110] (NiFe2O4@SiO2-H-14[NaP5W30O110]) was successfully synthesized and shown to be a versatile and highly efficient heterogeneous catalyst for one-pot multicomponent synthesis of 1,4-dihydropyridine derivatives under solvent-free condition. The synthesized catalyst can be magnetically recovered and reused four times without significant loss in catalytic efficiency.

  DOI：

  10.1134/s1070363217120325

文献信息

• One-Pot Synthesis of 1,4-Dihydropyridine Derivatives Catalyzed by Silica-Coated Magnetic NiFe2O4 Nanoparticles-Supported H14[NaP5W30O110]
  作者：B. Maleki、A. V. Mofrad、R. Tayebee、A. Khojastehnezhad、H. Alinezhad、E. Rezaei Seresht

  DOI：10.1134/s1070363217120325

  日期：2017.12

  Silica-coated magnetic NiFe2O4 nanoparticles-supported H-14[NaP5W30O110] (NiFe2O4@SiO2-H-14[NaP5W30O110]) was successfully synthesized and shown to be a versatile and highly efficient heterogeneous catalyst for one-pot multicomponent synthesis of 1,4-dihydropyridine derivatives under solvent-free condition. The synthesized catalyst can be magnetically recovered and reused four times without significant loss in catalytic efficiency.