2-bromo-1,2-di-furan-2-yl-ethanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-bromo-1,2-di-furan-2-yl-ethanone
• 英文别名: 2-Bromo-1,2-bis(furan-2-yl)ethanone
• 化学式: C₁₀H₇BrO₃
• 分子量: 255.068
• InChiKey: WJXJJXRQVMHHTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-呋喃羧酰胺 、 2-bromo-1,2-di-furan-2-yl-ethanone 以 氯仿 为溶剂， 生成 2,4,5-tris(furan-2-yl)-1H-imidazole
  参考文献：
  名称：

  Kempter,G. et al., Journal fur praktische Chemie (Leipzig 1954), 1971, vol. 313, p. 977 - 985

  摘要：

  DOI：

文献信息

• DIAMINOTHIAZOLES
  申请人：F. Hoffmann-La Roche AG

  公开号：EP1507530A1

  公开（公告）日：2005-02-23
• [EN] DIAMINOTHIAZOLES<br/>[FR] DIAMINOTHIAZOLES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2003097048A1

  公开（公告）日：2003-11-27

  The present invention is directed to novel diaminothiazoles of formula (I): These compounds inhibit cyclin-dependent kinase 4 (Cdk4) and are selective against Cdk2 and Cdkl. These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to their use for the preparation of medicaments for the treatment and control of cancer, most particularly the treatment or control of breast, lung and colon and prostate tumors.
• Kempter,G. et al., Journal fur praktische Chemie (Leipzig 1954), 1971, vol. 313, p. 977 - 985
  作者：Kempter,G. et al.

  DOI：——

  日期：——