(E)-3-(2-((3-methylbut-2-en-1-yl)oxy)phenyl)-1-phenylprop-2-en-1-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (E)-3-(2-((3-methylbut-2-en-1-yl)oxy)phenyl)-1-phenylprop-2-en-1-one
• 英文别名: (E)-2-O-isoprenylchalcone；(E)-3-[2-(3-methylbut-2-enoxy)phenyl]-1-phenylprop-2-en-1-one
• 化学式: C₂₀H₂₀O₂
• 分子量: 292.378
• InChiKey: WLOHADCBIYOCBF-OUKQBFOZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  水杨醛 在 potassium carbonate 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 N,N-二甲基甲酰胺 、 甘油 为溶剂， 反应 2.0h， 生成 (E)-3-(2-((3-methylbut-2-en-1-yl)oxy)phenyl)-1-phenylprop-2-en-1-one
  参考文献：
  名称：

  甘油中碱催化的Domino Aldol /杂-Diels-Alder合成三环吡喃并[3,4- c ]色烯

  摘要：

  在1,8存在下，将各种无环或环状单酮与异戊二烯系醚键合的醛组装在一起后，已成功实现了一些新的三环吡喃并[3,4- c ]色烯衍生物的多米诺羟醛/杂-Diels-Alder合成。-二氮杂双环[5.4.0]十一烷基-7-烯在120℃的甘油中。在单晶X射线衍射数据和2D NMR NOESY光谱以及中间Aldol缩合产物的分离和表征的基础上，研究并建立了该合成序列迄今未报道的立体化学结果。

  DOI：

  10.1021/acs.joc.6b00107

文献信息

• ANTI-INVASIVE COMPOUNDS
  申请人：Universiteit Gent

  公开号：US20150011620A1

  公开（公告）日：2015-01-08

  The present invention relates to the field of anti-invasive compounds and methods for predicting the anti-invasive activity of said compounds, as well as their use in the prevention and/or treatment of diseases associated with undesired cell invasion; in particular, this invention relates to the field of anti-invasive chalcone-like compounds.

  本发明涉及抗侵袭化合物领域，以及预测该类化合物抗侵袭活性的方法，以及它们在预防和/或治疗与不受欢迎的细胞侵袭相关的疾病中的用途；特别是，本发明涉及抗侵袭的类似香豆素化合物领域。
• Synthesis and evaluation of novel prenylated chalcone derivatives as anti-leishmanial and anti-trypanosomal compounds
  作者：Thais Gaban Passalacqua、Luiz Antonio Dutra、Letícia de Almeida、Angela Maria Arenas Velásquez、Fabio Aurelio Esteves Torres、Paulo Renato Yamasaki、Mariana Bastos dos Santos、Luis Octavio Regasini、Paul A.M. Michels、Vanderlan da Silva Bolzani、Marcia A.S. Graminha

  DOI：10.1016/j.bmcl.2015.05.072

  日期：2015.8

  Chalcones form a class of compounds that belong to the flavonoid family and are widely distributed in plants. Their simple structure and the ease of preparation make chalcones attractive scaffolds for the synthesis of a large number of derivatives enabling the evaluation of the effects of different functional groups on biological activities. In this Letter, we report the successful synthesis of a series of novel prenylated chalcones via Claisen-Schmidt condensation and the evaluation of their effect on the viability of the Trypanosomatidae parasites Leishmania amazonensis, Leishmania infantum and Trypanosoma cruzi. (C) 2015 Elsevier Ltd. All rights reserved.
• Chalcone derivatives
  申请人：TAISHO PHARMACEUTICAL CO. LTD

  公开号：EP0412803B1

  公开（公告）日：1994-03-23
• US9290427B2
  申请人：——

  公开号：US9290427B2

  公开（公告）日：2016-03-22
• [EN] ANTI-INVASIVE COMPOUNDS<br/>[FR] COMPOSÉS ANTI-INVASIFS
  申请人：UNIV GENT

  公开号：WO2013113722A1

  公开（公告）日：2013-08-08

  The present invention relates to the field of anti-invasive compounds and methods for predicting the anti-invasive activity of said compounds, as well as their use in the prevention and/or treatment of diseases associated with undesired cell invasion; in particular, this invention relates to the field of anti-invasive chalcone-like compounds.