(3,5-bis(hexadecyloxy)phenyl)methanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (3,5-bis(hexadecyloxy)phenyl)methanol
• 英文别名: (3,5-Dihexadecoxyphenyl)methanol；(3,5-dihexadecoxyphenyl)methanol
• 化学式: C₃₉H₇₂O₃
• 分子量: 588.999
• InChiKey: FDYNWKLSUHLPGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  16.5
• 重原子数：
  42
• 可旋转键数：
  33
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (3,5-bis(hexadecyloxy)phenyl)methanol 在 四溴化碳 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 反应 0.42h， 以78%的产率得到1-(bromomethyl)-3,5-bis(hexadecyloxy)benzene
  参考文献：
  名称：

  通过含烯二炔树枝状聚合物的bergman环化作用实现多壁碳纳米管的共价表面功能化

  摘要：

  利用含烯二炔化合物的Bergman环化作用产生的自由基，开发了一种多壁碳纳米管（MWCNT）的共价官能化方法。大量合成并表征了四种含烯二炔的Frechet型树状聚合物。然后，使含烯二炔的分子与N中的MWCNTs反应氮下于206°C时的2-甲基-2-吡咯烷酮。通过热重分析，紫外可见光谱，傅立叶变换红外光谱，拉曼光谱和透射电子显微镜对所得产物的结构和形态进行表征。树枝状聚合物官能化的MWCNT在常见的有机溶剂和聚合物溶液中显示出良好的溶解性/分散性。它们通过与聚己内酯电纺丝用于聚合物复合材料的形成。结果证实了MWCNT的表面功能化。©2011 Wiley Periodicals，Inc. J Polym Sci A部分：Polym Chem，2011年

  DOI：

  10.1002/pola.24834
• 作为产物：
  描述：

  3,5-二羟基苯甲酸甲酯 在 lithium aluminium tetrahydride 、 potassium carbonate 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 (3,5-bis(hexadecyloxy)phenyl)methanol
  参考文献：
  名称：

  用单组分可电离两亲性 Janus 树枝状聚合物靶向递送 mRNA

  摘要：

  用病毒和合成载体靶向和有效地递送核酸是基因纳米医学的关键步骤。由可电离脂质、磷脂、胆固醇和 PEG 结合脂质组成的四组分脂质纳米颗粒合成递送系统，通过微流体或 T 管技术组装，在递送 mRNA 以提供 Covid-19 疫苗方面非常成功。最近，我们报道了一种单组分多功能序列定义的可电离两亲性 Janus 树枝状聚合物 (IAJD) 合成递送系统，该系统依赖于我们实验室开发的两亲性 Janus 树枝状聚合物和糖树状聚合物。两亲性 Janus 树枝状聚合物由与疏水树枝共轭的功能性亲水树枝组成。IAJDs 与 mRNA 共组装成树枝状大分子纳米颗粒 (DNPs) 是通过在醋酸盐缓冲液中简单注射而不是通过微流体装置进行的，并提供了一个非常有效的系统来将 mRNA 输送到肺部。在这里，我们报告了 IAJD 中树突的大部分亲水性片段被替换，仅保留其可电离的胺，同时将其互连基团从酰胺变为酯的疏水树突。由此产生的

  DOI：

  10.1021/jacs.1c09585

文献信息

• Covalent surface functionalization of multiwalled carbon nanotubes through bergman cyclization of enediyne-containing dendrimers
  作者：Jianguo Ma、Sheng Deng、Xin Cheng、Wei Wei、Aiguo Hu

  DOI：10.1002/pola.24834

  日期：2011.9.15

  A method for covalent functionalization of multiwalled carbon nanotubes (MWCNTs) was developed using the free radicals generated through Bergman cyclization of enediyne‐containing compounds. Four enediyne‐bearing Frechet type dendrimers were synthesized in good quantities and characterized. Then, the enediyne‐containing molecules were reacted with MWCNTs in N‐methyl‐2‐pyrrolidinone at 206 °C under

  利用含烯二炔化合物的Bergman环化作用产生的自由基，开发了一种多壁碳纳米管（MWCNT）的共价官能化方法。大量合成并表征了四种含烯二炔的Frechet型树状聚合物。然后，使含烯二炔的分子与N中的MWCNTs反应氮下于206°C时的2-甲基-2-吡咯烷酮。通过热重分析，紫外可见光谱，傅立叶变换红外光谱，拉曼光谱和透射电子显微镜对所得产物的结构和形态进行表征。树枝状聚合物官能化的MWCNT在常见的有机溶剂和聚合物溶液中显示出良好的溶解性/分散性。它们通过与聚己内酯电纺丝用于聚合物复合材料的形成。结果证实了MWCNT的表面功能化。©2011 Wiley Periodicals，Inc. J Polym Sci A部分：Polym Chem，2011年
• Chemical modifications of resveratrol for improved protein kinase C alpha activity
  作者：Joydip Das、Satyabrata Pany、Anjoy Majhi

  DOI：10.1016/j.bmc.2011.08.008

  日期：2011.9

  Resveratrol (1) is a naturally occurring phytoalexin that affects a variety of human disease models, including cardio-and neuroprotection, immune regulation, and cancer chemoprevention. One of the possible mechanisms by which resveratrol affects these disease states is by affecting the cellular signaling network involving protein kinase C alpha (PKC alpha). PKC alpha is a member of the family of serine/threonine kinases, whose activity is inhibited by resveratrol. To study the structure-activity relationship, several monoalkoxy, dialkoxy and hydroxy analogs of resveratrol have been synthesized, tested for their cytotoxic effects on HEK293 cells, measured their effects on the membrane translocation properties of PKC alpha in the presence and absence of the PKC activator TPA, and studied their binding with the activator binding domain of PKC alpha. The analogs showed less cytotoxic effects on HEK293 cells and caused higher membrane translocation (activation) than that of resveratrol. Among all the analogs, 3, 16 and 25 showed significantly higher activation than resveratrol. Resveratrol analogs, however, inhibited phorbol ester-induced membrane translocation, and the inhibition was less than that of resveratrol. Binding studies using steady state fluorescence spectroscopy indicated that resveratrol and the analogs bind to the second cysteine-rich domain of PKC alpha. The molecular docking studies indicated that resveratrol and the analogs interact with the protein by forming hydrogen bonds through its hydroxyl groups. These results signify that molecules developed on a resveratrol scaffold can attenuate PKC alpha activity and this strategy can be used to regulate various disease states involving PKC alpha. (C) 2011 Elsevier Ltd. All rights reserved.
• Amphiphilic Diblock Dendrimers:  Synthesis and Incorporation in Langmuir and Langmuir−Blodgett Films
  作者：Jean-François Nierengarten、Jean-François Eckert、Yannick Rio、Maria del Pilar Carreon、Jean-Louis Gallani、Daniel Guillon

  DOI：10.1021/ja010155m

  日期：2001.10.1

  A new dendron with peripheral long alkyl chains and containing five C-60 units in the branching shell has been prepared and attached to a Frechet-type dendron functionalized with ethylene glycol chains. The peripheral substitution of the resulting globular dendrimer with hydrophobic chains on one hemisphere and hydrophilic groups on the other provides the perfect hydrophobic/hydrophilic balance allowing the formation of stable Langmuir films. Furthermore, a perfect reversibility has been observed in successive compression/decompression cycles. The diblock structure of the dendrimer has been also crucial for the efficient transfer of the Langmuir films in order to obtain well-ordered multilayered Langmuir-Blodgett films. This approach appears particularly interesting since functional groups not well adapted for the preparation of Langmuir and Langmuir-Blodgett films such as fullerenes can be attached into the branching shell of the dendritic structure and, thus, efficiently incorporated in thin ordered films.
• [EN] ONE-COMPONENT DELIVERY SYSTEM FOR NUCLEIC ACIDS<br/>[FR] SYSTÈME D'ADMINISTRATION À COMPOSANT UNIQUE POUR ACIDES NUCLÉIQUES
  申请人：[en]THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

  公开号：WO2022251191A1

  公开（公告）日：2022-12-01

  The invention relates to amphiphilic Janus dendrimers which may form nanoparticles. The invention also relates to methods of inducing an adaptive immune response in a subject comprising administering to the subject an effective amount of a composition comprising at least one nucleoside-modified RNA encoding at least one antigen and at least one amphiphilic Janus dendrimer and to methods of delivering an agent to a subject in need thereof, said method comprising the step of delivering to the subject a composition comprising an agent encapsulated by a nanoparticle.
• Targeted Delivery of mRNA with One-Component Ionizable Amphiphilic Janus Dendrimers
  作者：Dapeng Zhang、Elena N. Atochina-Vasserman、Devendra S. Maurya、Matthew Liu、Qi Xiao、Juncheng Lu、George Lauri、Nathan Ona、Erin K. Reagan、Houping Ni、Drew Weissman、Virgil Percec

  DOI：10.1021/jacs.1c09585

  日期：2021.11.3

  consisting of ionizable lipids, phospholipids, cholesterol, and a PEG-conjugated lipid, assembled by microfluidic or T-tube technology, have been extraordinarily successful for delivery of mRNA to provide Covid-19 vaccines. Recently, we reported a one-component multifunctional sequence-defined ionizable amphiphilic Janus dendrimer (IAJD) synthetic delivery system for mRNA relying on amphiphilic Janus dendrimers

  用病毒和合成载体靶向和有效地递送核酸是基因纳米医学的关键步骤。由可电离脂质、磷脂、胆固醇和 PEG 结合脂质组成的四组分脂质纳米颗粒合成递送系统，通过微流体或 T 管技术组装，在递送 mRNA 以提供 Covid-19 疫苗方面非常成功。最近，我们报道了一种单组分多功能序列定义的可电离两亲性 Janus 树枝状聚合物 (IAJD) 合成递送系统，该系统依赖于我们实验室开发的两亲性 Janus 树枝状聚合物和糖树状聚合物。两亲性 Janus 树枝状聚合物由与疏水树枝共轭的功能性亲水树枝组成。IAJDs 与 mRNA 共组装成树枝状大分子纳米颗粒 (DNPs) 是通过在醋酸盐缓冲液中简单注射而不是通过微流体装置进行的，并提供了一个非常有效的系统来将 mRNA 输送到肺部。在这里，我们报告了 IAJD 中树突的大部分亲水性片段被替换，仅保留其可电离的胺，同时将其互连基团从酰胺变为酯的疏水树突。由此产生的