2, 8-dimethyldibenzo[b,f][1,4]oxazepin-11(10H)-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2, 8-dimethyldibenzo[b,f][1,4]oxazepin-11(10H)-one
• 英文别名: 2,8-dimethyldibenzo[b,f][1,4]oxazepin-11(10H)-one；3,8-dimethyl-5H-benzo[b][1,4]benzoxazepin-6-one
• 化学式: C₁₅H₁₃NO₂
• 分子量: 239.274
• InChiKey: BSTRFWFCKCHAOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  dicobalt octacarbonyl 、 3-溴-4-氟甲苯 、 邻氨基对甲苯酚 在 palladium diacetate 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 以90%的产率得到2, 8-dimethyldibenzo[b,f][1,4]oxazepin-11(10H)-one
  参考文献：
  名称：

  使用八羰基二钴作为有效的 CO 源一锅法合成取代的二苯并氧杂氮杂酮和吡啶并苯并氧杂氮杂酮

  摘要：

  摘要 使用八羰基二钴 (Co2(CO)8) 作为有效的羰基金属源，从市售的芳基/杂芳基卤化物和氨基苯酚合成取代的二苯并氧杂氮杂酮和吡啶并苯并氧杂氮杂酮的简便一锅法已被证明。该方法通过芳基/杂芳基卤化物与氨基苯酚通过酰胺化和分子内环化的顺序偶联进行，得到二苯并恶氮杂酮/吡啶并苯并恶氮杂酮。图形概要

  DOI：

  10.1080/00397911.2019.1695277

文献信息

• A highly-efficient palladium-catalyzed aminocarbonylation/S_NAr approach to dibenzoxazepinones
  作者：Chaoren Shen、Helfried Neumann、Xiao-Feng Wu

  DOI：10.1039/c5gc00427f

  日期：——

  A practical protocol for the synthesis of dibenzo[b,e][1,4]oxazepin-11(5H)-ones has been developed. By virtue of Pd-catalyzed aminocarbonylation and aromatic nucleophilic substitution, 61 examples of the desired dibenzoxazepinones were obtained in moderate to excellent isolated yields (54-92%).

  已经开发了一种实用的合成二苯并[b，e] [1,4]草酰pin11（5H）-ones的协议。借助于Pd催化的氨基羰基化和芳族亲核取代，以中等至优异的分离产率（54-92％）获得了61个所需的二苯并恶嗪酮类实例。
• Novel sequences encoding hepatitis C virus glycoproteins
  申请人：Dumonceaux Julie

  公开号：US20080311150A1

  公开（公告）日：2008-12-18

  The present invention concerns a modified nucleic acid molecule comprising a nucleotide sequence coding for a full length hepatitis C virus (HCV) glycoprotein selected from the group consisting of E1 glycoprotein and E1/E2 glycoprotein heterodimer, this molecule having at least one nucleotide alteration, wherein, due to this alteration, at least one RNA splice site selected from the group consisting of RNA splice acceptor and RNA splice donor sites is eliminated from the coding sequence. The invention is also directed to methods for expressing on the surface of a cell and a pseudovirion an HCV glycoprotein, wherein the majority of the glycoprotein is full length. The invention further provides a cell and a pseudovirion expressing such glycoprotein. The invention still further provides a method for determining whether an agent inhibits HCV fusion with and entry into a target cell. The invention also provides an agent that inhibits HCV fusion with and entry into a target cell. The invention further provides methods for treating a subject afflicted with an HCV-associated disorder, for preventing an HCV infection in a subject, and for inhibiting in a subject the onset of an HCV-associated disorder.
• US7361503B2
  申请人：——

  公开号：US7361503B2

  公开（公告）日：2008-04-22
• One-pot synthesis of substituted dibenzoxazepinones and pyridobenzoxazepinones using octacarbonyldicobalt as an effective CO source
  作者：Kavitha Anchan、Poongavanam Baburajan、Nagaswarupa H. Puttappa、Sujit Kumar Sarkar

  DOI：10.1080/00397911.2019.1695277

  日期：2020.2.1

  Abstract A facile one-pot protocol for the synthesis of substituted dibenzoxazepinones and pyridobenzoxazepinones from commercially available aryl/heteroaryl halides and amino phenols using octacarbonyldicobalt (Co2(CO)8) as an effective metal carbonyl source has been demonstrated. This method proceeds via the sequential coupling of aryl/heteroaryl halides with aminophenol by amidation and intramolecular

  摘要 使用八羰基二钴 (Co2(CO)8) 作为有效的羰基金属源，从市售的芳基/杂芳基卤化物和氨基苯酚合成取代的二苯并氧杂氮杂酮和吡啶并苯并氧杂氮杂酮的简便一锅法已被证明。该方法通过芳基/杂芳基卤化物与氨基苯酚通过酰胺化和分子内环化的顺序偶联进行，得到二苯并恶氮杂酮/吡啶并苯并恶氮杂酮。图形概要