(2S)-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5,7,9(13),11-tetraene-11-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (2S)-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5,7,9(13),11-tetraene-11-carboxylic acid
• 化学式: C₁₃H₁₀FNO₄
• 分子量: 263.22
• InChiKey: KVVUTFTUKHKRKQ-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  66.8
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Anti acid-fast bacterial agent containing pyridonecarboxylic acids as active ingredient
  申请人：——

  公开号：US20030119848A1

  公开（公告）日：2003-06-26

  1 Anti-acid-fast bacterial agents containing as the active ingredient compounds represented by the general formula (1), salts thereof or hydrates of the same. Namely, pyridonecarboxylic acid derivatives having an excellent antibacterial activity on tubercle bacillus and a typical acid-fast bacteria, favorable kinetics in vivo and a high safety.

  抗酸快细菌药剂包含以一般式（1）表示的化合物作为活性成分，其盐或水合物。即，对结核杆菌和典型酸快细菌具有出色抗菌活性、在体内具有良好的动力学特性和高安全性的吡啶酮羧酸衍生物。
• Tricyclic amine derivatives
  申请人：——

  公开号：US20010037030A1

  公开（公告）日：2001-11-01

  The present invention relates to a compound having a tricyclic amine substituent which may have various substituents, the compound being represented by formula (I), a salt or hydrate thereof, and a hydrate of the salt and a drug containing them as an active ingredient. They exhibit excellent antimicrobial activity against Gram negative bacteria and Gram positive bacteria with a satisfactory fate and safety and are useful in the treatment of infectious diseases. 1 wherein Q preferably represents the following partial structure which may have various substituents: 2

  本发明涉及一种具有三环胺取代基的化合物，该化合物可以具有各种取代基，表示为式(I)的盐或水合物，盐的水合物和包含它们作为活性成分的药物。它们对革兰氏阴性菌和革兰氏阳性菌表现出优异的抗菌活性，具有令人满意的效果和安全性，适用于治疗传染病。其中Q最好表示以下可能具有各种取代基的部分结构：2
• PYRIDOBENZOXAZINE DERIVATIVE
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：EP1712554A1

  公开（公告）日：2006-10-18

  A quinolone antimicrobial agent having potent antimicrobial activity against gram positive and gram negative bacteria and having high safety is provided. A compound represented by the following formula (1): [wherein, R1: hydrogen, alkyl, cycloalkyl, or substituted carbonyl derived from amino acid, peptide or tripeptide; R2: hydrogen, alkyl, or cycloalkyl; R3: hydrogen, amino, halogen, or alkyl; R4: hydrogen, phenyl, acetoxymethyl, pivaloyloxymethyl, ethoxycarbonyl, choline, dimethylaminoethyl, 5-indanyl, phthalidinyl, 5-alkyl-2-oxo-1,3-dioxol-4-ylmethyl, 3-acetoxy-2-oxobutyl, alkyl, alkoxymethyl, or phenylalkyl; X, X1, X2: hydrogen or halogen] or salt thereof, or a hydrate thereof; and antimicrobial agent and therapeutic agent for infections, each containing the compound, salt thereof or a hydrate thereof.

  提供了一种对革兰氏阳性和阴性细菌具有强效抗菌活性且具有高安全性的喹诺酮类抗菌剂。化合物由以下公式（1）表示：[其中，R1：氢，烷基，环烷基或由氨基酸，肽或三肽衍生的取代羰基；R2：氢，烷基或环烷基；R3：氢，氨基，卤素或烷基；R4：氢，苯基，乙酰氧甲基，季戊酰氧甲基，乙氧羰基，胆碱，二甲氨基乙基，5-茚烷基，邻酞酰亚胺基，5-烷基-2-氧代-1,3-二氧杂环戊-4-基甲基，3-乙酰氧基-2-氧代丁基，烷基，烷氧甲基或苯基烷基；X，X1，X2：氢或卤素]或其盐或其水合物；以及包含该化合物、其盐或其水合物的抗菌剂和治疗剂。
• TRICYCLIC AMINE DERIVATIVES
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：EP0947513A1

  公开（公告）日：1999-10-06

  The present invention relates to a compound having a tricyclic amine substituent which may have various substituents, the compound being represented by formula (I), a salt or hydrate thereof, and a hydrate of the salt and a drug containing them as an active ingredient. They exhibit excellent antimicrobial activity against Gram negative bacteria and Gram positive bacteria with a satisfactory fate and safety and are useful in the treatment of infectious diseases. wherein Q preferably represents the following partial structure which may have various substituents:

  本发明涉及一种具有可具有各种取代基的三环胺取代基的化合物，该化合物由式（I）、其盐或水合物、盐的水合物以及含有它们作为活性成分的药物表示。它们对革兰氏阴性菌和革兰氏阳性菌都有很好的抗菌活性，而且安全性令人满意，可用于治疗传染性疾病。 其中 Q 优选代表以下部分结构，可具有各种取代基：
• ANTI-ACID-FAST BACTERIAL AGENTS CONTAINING PYRIDONECARBOXYLIC ACIDS AS THE ACTIVE INGREDIENT
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP1262477B1

  公开（公告）日：2008-09-03