(8-Methyl-8-azabicyclo[3.2.1]octan-3-yl) 2-oxo-1-propan-2-ylquinoline-3-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (8-Methyl-8-azabicyclo[3.2.1]octan-3-yl) 2-oxo-1-propan-2-ylquinoline-3-carboxylate
• 化学式: C₂₁H₂₆N₂O₃
• 分子量: 354.4
• InChiKey: KKWTZFHTXRSHFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  49.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• QUINOLINECARBOXYLIC ACID DERIVATIVE
  申请人：TAISHO PHARMACEUTICAL CO. LTD

  公开号：EP0710662A1

  公开（公告）日：1996-05-08

  A quinolinecarboxylic acid represented by general formula (C) or a medicinally acceptable salt thereof, each having a serotonergic receptor-stimulating effect on sertonin 4 receptors. In said formula, C represents hydroxymethyl, methoxy, ethoxy or morpholinyl. Therefore they have the effect of activating digestive motion and are efficacious in ameliorating chronic gastritis, diabetes and various diseases accompanying the lowering of stomach motility and gastric excretory function after gastrectomy, such as heartburn, anorexia, epigastralgia and abdominal swelling, and in treating reflux esophagitis, false ileus and constipation.

  通式(C)代表的喹啉羧酸或其可药用盐，每种都对舍托宁 4 受体具有血清素能受体刺激作用。 在所述通式中，C 代表羟甲基、甲氧基、乙氧基或吗啉基。 因此，它们具有激活消化运动的作用，对改善慢性胃炎、糖尿病和胃切除术后伴随胃蠕动和胃排泄功能降低的各种疾病，如胃灼热、厌食、上腹疼痛和腹胀，以及治疗反流性食管炎、假性回肠炎和便秘具有疗效。
• HETEROCYCLIC COMPOUND
  申请人：TAISHO PHARMACEUTICAL CO. LTD

  公开号：EP0748808A1

  公开（公告）日：1996-12-18

  Endo-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl) 1-isopropyl-2(1H)-quinolone-3-carboxylate represented by Formula (I): or an acid addition salt thereof acts on a serotonin 4 receptor thereby to have a serotonin-like receptor stimulating activity, therefore has an action on activating gastrointestinal motor functions and thus is effective for the improvement of gastrointestinal conditions such as heartburn, anorexia, bowel pain or abdominal distension accompanied by chronic gastritis or postoperative gastroparesis, and further for the treatment of gastro-esophagal reflux, intestinal pseudo-obstruction or constipation.

  由式(I)代表的内-(8-甲基-8-氮杂双环[3.2.1]辛-3-基) 1-异丙基-2(1H)-喹啉酮-3-甲酸内酯： 或其酸加成盐作用于 5-羟色胺 4 受体，从而具有 5-羟色胺样受体刺激活性，因此具有激活胃肠道运动功能的作用，从而有效改善胃肠道疾病，如烧心、厌食、肠痛或伴有慢性胃炎或术后胃瘫的腹胀，并进一步治疗胃食管反流、肠道假性梗阻或便秘。
• Quinolinecarboxylic acid derivatives
  申请人：ZENECA LIMITED

  公开号：EP1018513A2

  公开（公告）日：2000-07-12

  An 8-azabicyclo[3.2.1]octan-3-one derivative of formula (30): wherein R is (CH2)qD or CH2CF3; q is an integer of 2 to 6; and D is a hydroxymethyl group, an alkoxy group having 2 to 6 carbon atoms or a morpholinyl group. These compounds are useful as intermediates for pharmaceuticals and agrochemicals.

  式(30)的 8-氮杂双环[3.2.1]辛烷-3-酮衍生物： 其中 R 是 (CH2)qD 或 CH2CF3；q 是 2 至 6 的整数；D 是羟甲基、具有 2 至 6 个碳原子的烷氧基或吗啉基。这些化合物可用作药物和农用化学品的中间体。
• EP0748808A4
  申请人：——

  公开号：EP0748808A4

  公开（公告）日：1998-10-07
• US5733917A
  申请人：——

  公开号：US5733917A

  公开（公告）日：1998-03-31