7-(3-piperidin-1-ylpropoxy)-2,3,4,5-tetrahydro-1H-2-benzazepine;dihydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 7-(3-piperidin-1-ylpropoxy)-2,3,4,5-tetrahydro-1H-2-benzazepine;dihydrochloride
• 化学式: C18H30Cl2N2O
• 分子量: 361.3
• InChiKey: VDDRQMNXVOCNHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.82
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  24.5
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• [EN] SUBSTITUTED AZEPINES AS HISTAMINE H3 RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES<br/>[FR] AZEPINES SUBSTITUEES UTILISEES COMME ANTAGONISTES DES RECEPTEURS H3 DE L'HISTAMINE, LEUR PREPARATION ET LEURS UTILISATIONS THERAPEUTIQUES
  申请人：LILLY CO ELI

  公开号：WO2004018432A1

  公开（公告）日：2004-03-04

  The present invention discloses novel substituted azepine compounds of Formula (I) or pharmaceutically acceptable salts thereof which have selective histamine-H3 receptor antagonist activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such azepines as well as methods of using them to treat obesity and other histamine H3 receptor-related diseases.

  本发明公开了新型的Formula (I)的取代氮杂环庚烷化合物或其药学上可接受的盐，其具有选择性组胺-H3受体拮抗活性，以及制备这些化合物的方法。在另一实施方案中，本发明公开了包含这些氮杂环庚烷化合物的药物组合物，以及利用它们治疗肥胖和其他组胺H3受体相关疾病的方法。
• Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses
  申请人：Gadski Alan Robert

  公开号：US20060089347A1

  公开（公告）日：2006-04-27

  The present invention discloses novel substituted azepine compounds of Formula (I) or pharmaceutically acceptable salts thereof which have selective histamine-H3 receptor antagonist activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such azepines as well as methods of using them to treat obesity and other histamine H3 receptor-related diseases.

  本发明披露了一种新型的取代的氮杂七环化合物，其化学式为(I)，或其药学上可接受的盐，具有选择性的组胺H3受体拮抗作用，以及制备这种化合物的方法。在另一种实施方案中，本发明披露了包含这样的氮杂七环化合物的制药组合物，以及使用它们治疗肥胖和其他组胺H3受体相关疾病的方法。
• SUBSTITUTED AZEPINES AS HISTAMINE H3 RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES
  申请人：ELI LILLY AND COMPANY

  公开号：EP1539704A1

  公开（公告）日：2005-06-15