双环[3.2.1]辛烷-8-酮 | 55679-31-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 双环[3.2.1]辛烷-8-酮
• 英文名称: bicyclo<3.2.1>octan-8-one
• 英文别名: bicyclo[3.2.1]octan-8-one；Bicyclo[3.2.1]octan-8-on；8-Oxo-bicyclo<3.2.1>octan；Bicyclo<3.2.1>octan-2-on；Bicyclo<3.2.1>octan-8-on；8-Bicyclo<3,2,1>octanon
• CAS: 55679-31-7
• 化学式: C₈H₁₂O
• mdl: MFCD24390926
• 分子量: 124.183
• InChiKey: ZNSPMMFWDZEWQR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  双环[3.2.1]辛烷-8-酮 以54%的产率得到
  参考文献：
  名称：

  NELSEN, S. F.;KAPP, D. L., J. AMER. CHEM. SOC., 1986, 108, N 6, 1265-1270

  摘要：

  DOI：
• 作为产物：
  描述：

  Se-phenyl 4-cycloheptenecarboselenoate 在 偶氮二异丁腈 、 三正丁基氢锡 作用下， 以 苯 为溶剂， 反应 0.5h， 以58%的产率得到双环[3.2.1]辛烷-8-酮
  参考文献：
  名称：

  Acyl radicals: intermolecular and intramolecular alkene addition reactions

  摘要：

  A full study of the use of phenyl selenoesters as precursors to acyl radicals and their subsequent participation in intermolecular and intramolecular alkene addition reactions is detailed. Primary alkyl-, vinyl-, and aryl-substituted acyl radicals generated by Bu3SnH treatment of the corresponding phenyl selenoesters participate cleanly in intermolecular addition reactions with alkenes bearing electron-withdrawing or radical-stabilizing substituents at rates that exceed those of the potentially competitive decarbonylation or reduction. Similarly, their intramolecular addition to activated or unactivated alkenes proceeds without significant competitive reduction or decarbonylation and at rates generally greater-than-or-equal-to 1 x 10(6) s-1 with some occurring at rates greater-than-or-equal-to 3 x 10(7) s-1. Consistent with their behavior in intermolecular addition reactions, the 5-exo-trig cyclizations of secondary and tertiary alkyl-substituted acyl radicals to an unactivated olefin acceptor may be accompanied by varying degrees of decarbonylation, even under low-temperature free-radical reaction conditions. Studies are presented which suggest that the intramolecular additions of acyl radicals to alkenes under the conditions detailed herein may be regarded as irreversible, kinetically controlled processes which exhibit regioselectivity that is predictable based on well-established empirical rules set forth for the analogous free-radical cyclization reactions of alkyl radicals.

  DOI：

  10.1021/jo00031a021

文献信息

• Histamine H3 Inverse Agonists and Antagonists and Methods of Use Thereof
  申请人：Chytil Milan

  公开号：US20110065694A1

  公开（公告）日：2011-03-17

  Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including, e.g., neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as, e.g., histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical compositions containing the compounds and their methods of use are also provided herein.

  本文提供了融合咪唑基化合物，其合成方法以及使用方法。本文提供的化合物可用于治疗、预防和/或管理各种疾病，包括但不限于神经系统疾病和代谢性疾病。本文提供的化合物抑制组胺H3受体的活性，并调节各种神经递质的释放，例如组胺、乙酰胆碱、去甲肾上腺素和多巴胺（例如在突触处）。本文还提供了含有这些化合物的药物组合物及其使用方法。
• FRAGRANCE COMPOSITIONS COMPRISING IONIC LIQUIDS
  申请人：The Procter & Gamble Company

  公开号：US20160115424A1

  公开（公告）日：2016-04-28

  The present invention relates to a fragrance composition comprising ionic liquids for enhanced evaporation of the perfume raw materials. The invention also relates to methods of use of the fragrance compositions for perfuming suitable substrates, particularly skin and hair.

  本发明涉及一种包括离子液体的香精组合物，用于增强香料原料的蒸发。该发明还涉及使用这种香精组合物来为合适的基底，特别是皮肤和头发，进行香水处理的方法。
• Tricyclo[3.3.0.028]oct-3-enes: Their acid cleavage reactions and cycloadditions with dienophiles
  作者：Gary A. Fenton、Andrew Gilbert

  DOI：10.1016/s0040-4020(01)80125-3

  日期：1989.1

  Tricyclo[3.3.0.02 8]oct-3-enes are conveniently obtained by the photocycloaddition of ethenes to benzenoid compounds. Acid catalyzed cleavage of the cyclopropane ring in the photoadduct affords bicyclo[3.3.0] and [3.2.1]octane derivatives and dienophiles undergo [2π+2π] and [2π+2σ+2π] cycloaddition to the ethene and ethenylcyclopropane moieties respectively. The preferred mode of reaction for both

  三环[3.3.0.0 2 8 ]辛-3-烯可方便地通过将乙烯与苯类化合物光环加成而获得。酸催化的光加合物中环丙烷环的裂解提供双环[3.3.0]和[3.2.1]辛烷衍生物，二烯键合剂分别对乙烯和乙烯基环丙烷部分进行[2π+2π]和[2π+2σ+2π]环加成。两种方法的优选反应方式由环加合物中取代基的性质和位置控制。
• Fragrance Compositions Comprising Ionic Liquids
  申请人：The Procter & Gamble Company

  公开号：US20170121633A1

  公开（公告）日：2017-05-04

  The present invention relates to a fragrance composition comprising ionic liquids for delayed evaporation of the perfume raw materials. The invention also relates to methods of use of the fragrance compositions for perfuming suitable substrates, particularly skin and hair.

  本发明涉及一种香精组合物，包括离子液体，用于延迟香水原料的挥发。该发明还涉及使用香精组合物来香味适合的基质的方法，特别是皮肤和头发。
• Fluorous reverse-phase silica gel-supported Lewis acids as recyclable catalysts in water
  作者：Osamu Yamazaki、Xiuhua Hao、Akihiro Yoshida、Joji Nishikido

  DOI：10.1016/j.tetlet.2003.09.183

  日期：2003.12

  Fluorous reverse-phase silica gel (FRPSG)-supported Lewis acids which have fluorous ligands acted as effective catalysts of Baeyer–Villiger and Diels–Alder reactions in water. Direct esterification of carboxylic acid with alcohol in organic media was also catalyzed. The FRPSG-supported Lewis acids could be recycled by simple filtration after the reaction.

  含氟配体的氟反相硅胶（FRPSG）支撑的路易斯酸可在水中作为Baeyer-Villiger和Diels-Alder反应的有效催化剂。还催化了羧酸与醇在有机介质中的直接酯化。反应后，可通过简单过滤将FRPSG负载的路易斯酸回收。