(1s,4s)-tert-butyl 4-hydroxy-1-(methoxymethyl)cyclohexanecarboxylate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1s,4s)-tert-butyl 4-hydroxy-1-(methoxymethyl)cyclohexanecarboxylate
• 英文别名: Rel-tert-butyl (1s,4s)-4-hydroxy-1-(methoxymethyl)cyclohexane-1-carboxylate；tert-butyl 4-hydroxy-1-(methoxymethyl)cyclohexane-1-carboxylate
• 化学式: C₁₃H₂₄O₄
• 分子量: 244.331
• InChiKey: WHYAKPZUCXELDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-羟基-5-硝基吡啶 、 (1s,4s)-tert-butyl 4-hydroxy-1-(methoxymethyl)cyclohexanecarboxylate 在 偶氮二甲酸二异丙酯 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 反应 0.92h， 以69%的产率得到(1r,4r)-tert-butyl 1-(methoxymethyl)-4-(5-nitropyridin-2-yloxy)cyclohexanecarboxylate
  参考文献：
  名称：

  [EN] OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS
  [FR] COMPOSÉS CHIMIQUES 979

  摘要：

  公开号：

  WO2009024821A3
• 作为产物：
  描述：

  (1s,4s)-tert-butyl 4-(tert-butyldimethylsilyloxy)-1-(methoxymethyl)cyclohexanecarboxylate 以 四氢呋喃 为溶剂， 反应 12.0h， 以73.3%的产率得到(1s,4s)-tert-butyl 4-hydroxy-1-(methoxymethyl)cyclohexanecarboxylate
  参考文献：
  名称：

  [EN] OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS
  [FR] COMPOSÉS CHIMIQUES 979

  摘要：

  公开号：

  WO2009024821A3

文献信息

• CATALYST COMPONENT FOR OLEFIN POLYMERIZATION AND APPLICATION THEREOF
  申请人：Beijing Lihe Technology Ltd.

  公开号：US20170283530A1

  公开（公告）日：2017-10-05

  Provided is a solid catalyst component for olefin polymerization, which comprises Mg, Ti, a halogen and an electron donor. The electron donor is selected from at least one of ring-substituted ether-acid ester compounds of the general formula (I). Also provided are a catalyst containing the solid catalyst component and the application of the catalyst in reactions of olefin polymerization, particularly in the reaction of propylene polymerization.

  提供了一种用于烯烃聚合的固体催化剂组分，包括镁、钛、卤素和电子给体。电子给体从通式（I）的环取代醚酸酯化合物中至少选择一个。还提供了含有该固体催化剂组分的催化剂以及在烯烃聚合反应中应用该催化剂的方法，特别是在丙烯聚合反应中的应用。
• CHEMICAL COMPOUNDS 979
  申请人：Birch Alan Martin

  公开号：US20110092547A1

  公开（公告）日：2011-04-21

  Compounds of formula (I), or pharmaceutically-acceptable salts and/or pro-drugs thereof, which inhibit acetyl CoA(acetyl coenzyme A):diacylglycerol acyltransferase (DGAT1) activity are provided, wherein n is 0 to 3; p is 0 or 1; q is 0 to 2; R 1 and R 2 are, for example, independently fluoro, chloro, bromo, cyano or (1-4C)alkyl; X is —O—, —S— or —NRa— wherein Ra is hydrogen or (1-4C)alkyl; R A1 and R A2 are, for example, independently hydrogen or (1-4C)alkyl; Ring A is a di-linked ring or ring system chosen from (4-6C)cycloalkane, (7-10C)bicycloalkane and (8-12C)tricycloalkane each optionally substituted, for example, by one substituent selected from (1-4C)alkyl, (1-4C)alkoxy and (1-4C)alkoxy(1-4C)alkyl; or Ring A is phenylene optionally substituted, for example, by up to four substituents selected from fluoro, chloro, bromo, cyano, (1-4C)alkyl, (1-4C)alkoxy and (1-4C)alkoxy( 1 -4C)alkyl; together with processes for their preparation, pharmaceutical compositions containing them and their use as medicaments.

  提供公式（I）的化合物，或其药学上可接受的盐和/或前药，其抑制乙酰辅酶A：二酰基甘油酰基转移酶（DGAT1）活性，其中n为0至3；p为0或1；q为0至2；R1和R2例如独立地为氟、氯、溴、氰或（1-4C）烷基；X为—O—、—S—或—NRa—，其中Ra为氢或（1-4C）烷基；RA1和RA2例如独立地为氢或（1-4C）烷基；环A为二联环或环系统，选择自（4-6C）环烷、（7-10C）双环烷和（8-12C）三环烷，每个环可选地被一个取代基取代，所述取代基选择自（1-4C）烷基、（1-4C）烷氧基和（1-4C）烷氧基（1-4C）烷基；或环A为苯环，可选地被多达四个取代基取代，所述取代基选择自氟、氯、溴、氰、（1-4C）烷基、（1-4C）烷氧基和（1-4C）烷氧基（1-4C）烷基；以及它们的制备过程、含有它们的药物组合物和它们作为药物的用途。
• Catalyst component for olefin polymerization and application thereof
  申请人：Beijing Lihe Technology Ltd.

  公开号：US10208146B2

  公开（公告）日：2019-02-19

  Provided is a solid catalyst component for olefin polymerization, which comprises Mg, Ti, a halogen and an electron donor. The electron donor is selected from at least one of ring-substituted ether-acid ester compounds of the general formula (I). Also provided are a catalyst containing the solid catalyst component and the application of the catalyst in reactions of olefin polymerization, particularly in the reaction of propylene polymerization.

  本发明提供了一种用于烯烃聚合的固体催化剂组分，它由 Mg、Ti、卤素和电子供体组成。电子供体选自通式（I）的环取代醚酸酯化合物中的至少一种。此外，还提供了一种含有固体催化剂组分的催化剂，以及该催化剂在烯烃聚合反应，特别是丙烯聚合反应中的应用。
• OLEFIN POLYMERIZATION CATALYST CARRIER, SOLID CATALYST COMPONENT AND USE THEREOF
  申请人：Renqiu Lihe Technology Ltd.

  公开号：US20170355792A1

  公开（公告）日：2017-12-14

  Provided is an olefin polymerization catalyst carrier with a general structure formula of Mg(OR I ) n (OR II ) 2-n , wherein: 0≦n≦2, and R I and R II can be the same or different and are each independently selected from a C 1 -C 20 hydrocarbon group. In the X-ray diffraction pattern of the catalyst carrier, there are a set of diffraction peaks in the range of a 2θ diffraction angle of 5°-15°, and the set of diffraction peaks contain 1-4 main diffraction peaks. Also disclosed is an olefin polymerization solid catalyst component which is prepared from the carrier Mg(OR I ) n (OR II ) 2-n , a titanium compound, and at least one electron donor compound. In addition, also disclosed is an olefin polymerization catalyst containing the solid catalyst component, at least one organic aluminum compound, and optionally, an external electron donor compound.
• [EN] OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS<br/>[FR] COMPOSÉS CHIMIQUES 979
  申请人：ASTRAZENECA AB

  公开号：WO2009024821A3

  公开（公告）日：2009-04-09