Carmoterol Stereocenters

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Carmoterol Stereocenters
• 英文别名: 8-hydroxy-5-[1-hydroxy-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethyl]-1H-quinolin-2-one
• 化学式: C₂₁H₂₄N₂O₄
• 分子量: 368.4
• InChiKey: IHOXNOQMRZISPV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  90.8
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Process for Preparing Isomers of Carmoterol
  申请人：Kankan Rajendra Narayanrao

  公开号：US20100113790A1

  公开（公告）日：2010-05-06

  A process for preparing a compound of formula (III) comprising condensing an oxiranyl compound of formula (I) with an amine of formula (II) or a salt thereof wherein: R 1 is a group selected from alkyl, aryl, allyl, alkoxy, cycloalkyl, heterocyclic, alkenyl, benzocycloalkyl, aralkyl, haloarylalkyl, heteroaralkyl, haloalkyl, alkoxyaralkyl, substituted silyl and benzyl; and R 2 is hydrogen, optionally substituted silyl or optionally substituted benzyl. There is also described a process for preparing (R,R)-carmoterol from compound (III).

  一种制备式（III）化合物的方法，包括将式（I）的环氧丙烷化合物与式（II）的胺或其盐缩合，其中：R1是从烷基，芳基，烯丙基，烷氧基，环烷基，杂环基，烯基，苯并环烷基，芳基烷基，卤代芳基烷基，杂环芳基烷基，卤代烷基，烷氧基芳基烷基，取代硅基和苄基中选择的基团；R2是氢，可选的取代硅基或可选的取代苄基。还描述了从化合物（III）制备（R，R）-卡莫特罗尔的方法。
• PREPARATION OF (R,R)-FENOTEROL AND (R,R)-OR (R,S)-FENOTEROL ANALOGUES AND THEIR USE IN TREATING CONGESTIVE HEART FAILURE
  申请人：Wainer Irving W.

  公开号：US20120157543A1

  公开（公告）日：2012-06-21

  This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding β2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.

  本公开涉及(R,R)-和(R,S)-芬特罗类似物的发现，它们在结合β2-肾上腺素受体方面具有高度有效性。提供了这些类似物的示例化学结构。还提供了包括所披露的(R,R)-芬特罗和芬特罗类似物的制药组合物，以及使用这些化合物和组合物治疗心脏疾病，如充血性心力衰竭和肺部疾病，如哮喘或慢性阻塞性肺疾病的方法。
• Sulfonamide Compounds for the Treatment of Respiratory Disorders
  申请人：Ramdas Vidya

  公开号：US20120041043A1

  公开（公告）日：2012-02-16

  Compounds of formula (I) are agonists of PPARγ, useful for the treatment of respiratory disease; formula (I): wherein R 1 , R 2 or R 3 each independently represents halo, cyano, nitro, amino, alkyl, haloalkyl, alkoxy, haloalkoxy, carboxylic acid or an ester or amide thereof; R 4 represents hydrogen or alkyl; m, n or p independently represents 0, 1, 2 or 3.

  式(I)的化合物是PPARγ激动剂，用于治疗呼吸系统疾病；式(I)：其中，R1、R2或R3各自独立地代表卤素、氰基、硝基、氨基、烷基、卤代烷基、烷氧基、卤代烷氧基、羧酸或其酯或酰胺；R4代表氢或烷基；m、n或p各自独立地代表0、1、2或3。
• CONJUGATED DIENE POLYMER AND METHOD FOR PRODUCING SAME
  申请人：Bando Fumiaki

  公开号：US20140350201A1

  公开（公告）日：2014-11-27

  Conjugated diene polymer comprising at least a conjugated diene monomer unit, the conjugated diene polymer has a number-average molecular weight (Mn) in terms of polystyrene of 1,000 to 1,000,000, a ratio (Mw/Mn) of a weight-average molecular weight (Mw) to the number-average molecular weight (Mn) of lower than 2.0 and the polymer bears a halogen atom at a terminal of the polymer chain. Method for producing the conjugated diene polymer comprises subjecting a monomer containing at least a conjugated diene to living radical polymerization using a polymerization initiator comprising a halogenocyclopentadienyl triorganophosphine η 2 -olefin ruthenium complex represented by formula (6) (and an organic halide.

  共轭二烯聚合物包括至少一个共轭二烯单体单元，该共轭二烯聚合物的聚合度数平均分子量（Mn）以聚苯乙烯为单位为1,000至1,000,000，重均分子量（Mw）与数均分子量（Mn）之比小于2.0，并且该聚合物在聚合物链的末端带有卤素原子。制备该共轭二烯聚合物的方法包括使用聚合引发剂将至少含有一个共轭二烯的单体进行活性自由基聚合，所述聚合引发剂包括一个卤代环戊二烯基三有机膦η2-烯烃钌配合物，其化学式为（6）（和一个有机卤化物）。
• MEDICAMENTS FOR INHALATION COMPRISING AN ANTICHOLINERGIC AND A BETAMIMETIC
  申请人：Meade Christopher John Montague

  公开号：US20090155185A1

  公开（公告）日：2009-06-18

  A pharmaceutical composition comprising an anticholinergic and a betamimetic of formula 2 optionally together with a pharmaceutically acceptable excipient, the anticholinergic and the betamimetic optionally in the form of their enantiomers, mixtures of their enantiomers, their racemates, their solvates, or their hydrates, processes for preparing them, and their use in the treatment of asthma, COPD, or other inflammatory or obstructive respiratory complaints.

  一种药物组合物，包括抗胆碱能药和公式2的β-肾上腺素受体激动剂，可选地与药学上可接受的赋形剂一起使用，抗胆碱能药和β-肾上腺素受体激动剂可以是其对映体形式、对映体混合物、拉克酸盐、溶剂化物或水合物形式，以及用于治疗哮喘、COPD或其他炎症或阻塞性呼吸道疾病的用途，以及其制备方法。