2-(4-Methylphenyl)sulfonyl-3-phenyl-5-(trifluoromethyl)-3,4-dihydropyrazole

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-Methylphenyl)sulfonyl-3-phenyl-5-(trifluoromethyl)-3,4-dihydropyrazole
• 化学式: C₁₇H₁₅F₃N₂O₂S
• 分子量: 368.4
• InChiKey: IINSFTGLZJRWJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  58.1
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• [EN] 1-(4-ARYLSULFONYL)-3-SUBSTITUTED-5-ARYL-2-PYRAZOLINES AS INHIBITORS OF CYCLOOXYGENASE-2<br/>[FR] 1-(4-ARYLESULFONYLE)-3-SUBSTITUE-5-ARYLE-2-PYRAZOLINES COMME INHIBITEURS DE LA CYCLO-OXYGENASE-2
  申请人：UNIV TEMPLE

  公开号：WO2000076983A1

  公开（公告）日：2000-12-21

  Compounds of formula (I) are provided wherein: X is selected from the group consisting of trihalomethyl, C1-C6 alkyl, and a group of formula (II) wherein: R3 and R4 are independently selected from the group consisting of hydrogen; halogen; hydroxyl; nitro; C1-C6 alkyl; C1-C6 alkoxy; carboxy; C1-C6 trihaloalkyl; and cyano; Z is selected from the group consisting of substituted and unsubstituted aryl; and Q is selected from the group consisting of substituted and unsubstituted phenyl; or a pharmaceutically acceptable salt thereof. The compounds are inhibitors of cyclooxygenase-2 activity. They are useful for treating inflammation and cyclooxygenase-mediated disorders.