2-methyl-2-dodecenal

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-methyl-2-dodecenal
• 英文别名: 2-methyl-dodec-2-enal
• 化学式: C₁₃H₂₄O
• 分子量: 196.333
• InChiKey: WSDPKCGIKITSCT-ACCUITESSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.27
• 重原子数：
  14.0
• 可旋转键数：
  9.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  17.07
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  2-methyl-2-dodecenal 在 silver(l) oxide 作用下， 生成 2-甲基-2-十二碳烯酸
  参考文献：
  名称：

  The clinical utility of the Hopkins Verbal Learning Test as a screening test for mild dementia

  摘要：

  Objective: The purpose of this study was to determine whether the Hopkins Verbal Learning Test (HVLT) could be used as a valid and reliable screening test for mild dementia in older people, and to compare its performance to that of the Mini-Mental State Examination (MMSE). Method: Using a cross-sectional design, we studied three groups of older subjects recruited from a district geriatric psychiatry service: (1) 26 patients with DSM-IV dementia and MMSE scores of 18 or better; (2) 15 patients with psychiatric diagnoses other than dementia; and (3) 15 normal controls. The relationship of each potential cutting point on the HVLT and the MMSE was examined against the independently ascertained DSM-IV diagnoses of dementia using a Receiver Operating Characteristic (ROC) analysis. Results: The subjects consisted of 21 (37.5%) males and 35 (62.5%) females with a mean age of 74.7 (SD 6.1) years and a mean of 8.5 (SD 1.8) years of formal education. ROC analysis indicated that the optimal cutting point for detecting mild dementia in this group of subjects using the HVLT was 18/19 (sensitivity=0.96, specificity=0.80) and using the MMSE was 25/26 (sensitivity=0.88, specificity=0.93). Conclusions: The HVLT can be recommended as a valid and reliable screening test for mild dementia and as an adjunct in the clinical assessment of older people. The HVLT had better sensitivity than the MMSE in detecting patients with mild dementia, whereas the MMSE had better specificity.

  DOI：

  10.1002/(sici)1099-1166(200004)15:4<317::aid-gps116>3.0.co;2-7
• 作为产物：
  描述：

  癸醛 、 丙醛 在 哌啶 、 溶剂黄146 作用下， 以 乙腈 为溶剂， 反应 3.0h， 以89%的产率得到2-methyl-2-dodecenal
  参考文献：
  名称：

  E，E-乙烯基乙烯酮甲硅烷基N，O-缩醛的立体选择性酰化及其在合成Khafrefungin中的应用

  摘要：

  通过使用酸酐和SnCl 4已经实现了具有手性助剂的E，E-乙烯基乙烯酮甲硅烷基N，O-乙缩醛的立体选择性酰化。具有烷基链的酸酐以优异的立体选择性得到加合物。该方法已完成了khafrefungin的正式合成。

  DOI：

  10.1021/ol501805j

文献信息

• Stereoselective Acylation of the <i>E</i>,<i>E</i>-Vinylketene Silyl <i>N</i>,<i>O</i>-Acetal and Its Application to the Synthesis of Khafrefungin
  作者：Yuta Takahashi、Maiko Otsuka、Mio Harachi、Yuki Mukaeda、Seijiro Hosokawa

  DOI：10.1021/ol501805j

  日期：2014.8.15

  Stereoselective acylation of the E,E-vinylketene silyl N,O-acetal possessing a chiral auxiliary has been achieved by using acid anhydrides and SnCl4. Acid anhydrides having alkyl chains gave the adducts in excellent stereoselectivity. The formal synthesis of khafrefungin has been accomplished by the methodology.

  通过使用酸酐和SnCl 4已经实现了具有手性助剂的E，E-乙烯基乙烯酮甲硅烷基N，O-乙缩醛的立体选择性酰化。具有烷基链的酸酐以优异的立体选择性得到加合物。该方法已完成了khafrefungin的正式合成。
• The clinical utility of the Hopkins Verbal Learning Test as a screening test for mild dementia
  作者：Rowena M. Frank、Gerard J. Byrne

  DOI：10.1002/(sici)1099-1166(200004)15:4<317::aid-gps116>3.0.co;2-7

  日期：2000.4

  Objective: The purpose of this study was to determine whether the Hopkins Verbal Learning Test (HVLT) could be used as a valid and reliable screening test for mild dementia in older people, and to compare its performance to that of the Mini-Mental State Examination (MMSE). Method: Using a cross-sectional design, we studied three groups of older subjects recruited from a district geriatric psychiatry service: (1) 26 patients with DSM-IV dementia and MMSE scores of 18 or better; (2) 15 patients with psychiatric diagnoses other than dementia; and (3) 15 normal controls. The relationship of each potential cutting point on the HVLT and the MMSE was examined against the independently ascertained DSM-IV diagnoses of dementia using a Receiver Operating Characteristic (ROC) analysis. Results: The subjects consisted of 21 (37.5%) males and 35 (62.5%) females with a mean age of 74.7 (SD 6.1) years and a mean of 8.5 (SD 1.8) years of formal education. ROC analysis indicated that the optimal cutting point for detecting mild dementia in this group of subjects using the HVLT was 18/19 (sensitivity=0.96, specificity=0.80) and using the MMSE was 25/26 (sensitivity=0.88, specificity=0.93). Conclusions: The HVLT can be recommended as a valid and reliable screening test for mild dementia and as an adjunct in the clinical assessment of older people. The HVLT had better sensitivity than the MMSE in detecting patients with mild dementia, whereas the MMSE had better specificity.